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The role of kidney registries in expediting large-scale collection of patient-reported outcome measures for people with chronic kidney disease

Published 7 September 2021 Photo: Pixabay / www_slon_pics In this editorial, we discuss the current state-of-play of PROMs collection by kidney registries and provide an overview of what is (un)known about the feasibility and effectiveness of PROMs in CKD and other conditions. Read the paper at https://academic.oup.com/ckj/article/14/6/1495/6173985

https://www.lupop.lu.se/article/role-kidney-registries-expediting-large-scale-collection-patient-reported-outcome-measures-people - 2025-02-09

SWEDEGENE—a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions

Published 8 September 2021 Photo: Pixabay / Arek Socha SWEDEGENE was established in 2008 and currently contains DNA and information from about 2550 adults who have experienced specific ADRs, and from 580 drug exposed controls. Read the paper at https://www.nature.com/articles/s41397-020-0148-3

https://www.lupop.lu.se/article/swedegene-swedish-nation-wide-dna-sample-collection-pharmacogenomic-studies-serious-adverse-drug - 2025-02-09

Bias Analysis Gone Bad

Published 8 September 2021 We identified 3 examples of suboptimal bias analysis, one for each common bias. For each, we describe the original research and its bias analysis, compare the bias analysis with good practices, and describe how the bias analysis and research findings might have been improved. Read the paper at https://academic.oup.com/aje/article/190/8/1604/6189735

https://www.lupop.lu.se/article/bias-analysis-gone-bad - 2025-02-09

Emulating Target Trials to Improve Causal Inference From Agent-Based Models

Published 9 September 2021 Photo: Pixabay / Gerd Altmann In this paper, we describe the use of the target trial framework for designing agent-based models when the goal is estimation of causal effects in the presence of interference, or spillover. Read the paper at https://academic.oup.com/aje/article/190/8/1652/6140873

https://www.lupop.lu.se/article/emulating-target-trials-improve-causal-inference-agent-based-models - 2025-02-09

European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria

Published 9 September 2021 Photo: Pixabay / Arek Socha This registry is expected to provide insights into the long-term durability of different strategies of surgical repair for TAAD. Read the paper at https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019…

https://www.lupop.lu.se/article/european-registry-type-aortic-dissection-ertaad-rationale-design-and-definition-criteria - 2025-02-09

Propensity Score Weighting and Trimming Strategies for Reducing Variance and Bias of Treatment Effect Estimates: A Simulation Study

Published 10 September 2021 To extend previous simulations on the performance of propensity score (PS) weighting and trimming methods to settings without and with unmeasured confounding, Poisson outcomes, and various strengths of treatment prediction (PS c statistic), we simulated studies with a binary intended treatment T as a function of 4 measured covariates. Read the paper at https://academic.

https://www.lupop.lu.se/article/propensity-score-weighting-and-trimming-strategies-reducing-variance-and-bias-treatment-effect - 2025-02-09

Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses

Published 11 September 2021 Photo: Pixabay / VSRao The benefits of using data from national registers as endpoints in epidemiological studies must be weighed against the impact of potentially decreased data quality. Read the paper at https://journals.sagepub.com/doi/full/10.1177/14034948211021191

https://www.lupop.lu.se/article/data-national-health-registers-endpoints-tromso-study-correctness-and-completeness-stroke-diagnoses - 2025-02-09

A cautionary note on a recently proposed sensitivity analysis for unmeasured confounding

Published 11 September 2021 Unmeasured confounding is a common threat to the validity of observational studies. In practice, confounding bias may arise from both confounders that are completely unmeasured and from confounders that are measured with error. Read the paper at https://academic.oup.com/ije/article/50/3/711/6048186

https://www.lupop.lu.se/article/cautionary-note-recently-proposed-sensitivity-analysis-unmeasured-confounding - 2025-02-09

Use of register- and survey-based measures of anxiety in a population-based Danish cohort

Published 12 September 2021 Photo: Pixabay / Brian Merrill We explored the comparability of anxiety measures from register- and survey-based data including analyses of prevalence and associations with selected psychiatric and somatic diseases. Read the paper at https://onlinelibrary.wiley.com/doi/full/10.1111/acps.13339

https://www.lupop.lu.se/article/use-register-and-survey-based-measures-anxiety-population-based-danish-cohort - 2025-02-09

Analytical approaches to minimizing immeasurable time bias in cohort studies

Published 12 September 2021 Photo: Pixabay / Gerd Altmann Immeasurable time bias exaggerates drug benefits in pharmacoepidemiological studies due to exposure misclassification arising from the inability to measure in-hospital medications in many health care databases. Read the paper at https://academic.oup.com/ije/article/50/3/987/6048410

https://www.lupop.lu.se/article/analytical-approaches-minimizing-immeasurable-time-bias-cohort-studies - 2025-02-09

Reflection on modern methods: a common error in the segmented regression parameterization of interrupted time-series analyses

Published 13 September 2021 Interrupted time-series (ITS) designs are a robust and increasingly popular non-randomized study design for strong causal inference in the evaluation of public health interventions. Read the paper at https://academic.oup.com/ije/article/50/3/1011/5937253

https://www.lupop.lu.se/article/reflection-modern-methods-common-error-segmented-regression-parameterization-interrupted-time-series - 2025-02-09

A snapshot of European registries on Chronic Kidney Disease patients not on Kidney Replacement Therapy

Published 13 September 2021 Photo: Pixabay / www_slon_pics We report the current status of CKD registries in Europe in relation to their data collection on patients not on KRT so that in the future we may investigate to what extent also their data may be used for similar purposes, like collaborative research on CKD trajectories and patient outcomes. Read the paper at https://academic.oup.com/ndt/a

https://www.lupop.lu.se/article/snapshot-european-registries-chronic-kidney-disease-patients-not-kidney-replacement-therapy - 2025-02-09

Completeness of esophageal cancer diagnosis in the Finnish Cancer Registry and hospital discharge registry, a nationwide study in Finland

Published 14 September 2021 Photo: Pixabay / Gerd Altmann The aim of this study was to explore the potential misclassification and evaluate the completeness of esophageal cancer diagnoses in the FCR and HILMO, considering misclassification. Read the paper at https://www.tandfonline.com/doi/full/10.1080/0284186X.2020.1792547

https://www.lupop.lu.se/article/completeness-esophageal-cancer-diagnosis-finnish-cancer-registry-and-hospital-discharge-registry - 2025-02-09

Reliability of self-reported questionnaire for epidemiological investigation of Helicobacter pylori eradication in a population-based cohort study

Published 15 September 2021 Photo: Pixabay / Gerd Altmann General population-based cohort studies provide solid evidence on mass Helicobacter pylori (HP) eradication effects. Self-reported questionnaires are occasionally used in such studies to ascertain the HP eradication history. However, reports on the reliability of these questionnaires are lacking. Read the paper at https://www.nature.com/art

https://www.lupop.lu.se/article/reliability-self-reported-questionnaire-epidemiological-investigation-helicobacter-pylori - 2025-02-09

Validity of an algorithm to identify cardiovascular deaths from administrative health records: a multi-database population-based cohort study

Published 15 September 2021 Photo: Pixabay / Ben Kerckx A cardiovascular mortality algorithm applied to administrative health records had moderate validity when compared to vital statistics data. Substantial variation existed across study sites representing different geographic locations and two healthcare systems. These variations may reflect different diagnostic coding practices and healthcare u

https://www.lupop.lu.se/article/validity-algorithm-identify-cardiovascular-deaths-administrative-health-records-multi-database - 2025-02-09

Reflection on modern methods: building causal evidence within high-dimensional molecular epidemiological studies of moderate size

Published 16 September 2021 This commentary provides a practical perspective on epidemiological analysis within a single high-dimensional study of moderate size to consider a causal question. Read the paper at https://academic.oup.com/ije/article/50/3/1016/6140018

https://www.lupop.lu.se/article/reflection-modern-methods-building-causal-evidence-within-high-dimensional-molecular-epidemiological - 2025-02-09