Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays important roles in organ development and tissue orientation. Previous studies have reported that Wnt5a was upregulated at both mRNA and protein levels in prostate cancer, but information regarding its role in predicting clinical outcome in patients after radical prostatectomy is limited. The aim of the present thesis is to

Popular Abstract in Swedish Traditionellt sett har man tänkt sig att gradvisa förändringar i yttre miljöfaktorer leder till lika gradvisa ekosystemförändringar, men vi vet nu att ekosystem som utsätts för mänsklig påverkan eller klimatförändringar kan reagera kraftigt och abrupt genom att ett ekologiskt tröskelvärde överskrids varvid en förändring sker från en stabil ekologisk situation till en anRegime shifts in lake ecosystems can occur in response to both abrupt and continuous climate change, and the imprints they leave in palaeolimnological records allow us to investigate and better understand patterns and processes governing ecological changes on geological time scales. This thesis aims at investigating palaeolimnological records of regime shifts in lakes during the Holocene to explor

The chemical composition and dissociation behaviour of water adsorbed on clean and oxygen pre-covered Pd{111} was studied using high-resolution time-resolved and temperature-programmed X-ray photoelectron spectroscopy. We find that water remains intact at all temperatures up to desorption on the clean surface and at high oxygen coverage(0.69 ML) when a surface oxide is formed. The highest desorpti

The intrinsic properties of vertical InAs nanowire (NW) capacitors are investigated. The band structure is simulated using a Schrödinger-Poisson solver, taking the conduction band nonparabolicity into account. This is combined with a distributed RC model to simulate the current-voltage characteristics. It is found that the influence from the nonparabolicity is substantial for devices with a small

This work compares the extent of linear response regions from standard time-resolving optical detectors for phosphor thermometry. Different types of photomultipliers (ordinary and time-gated) as well as an avalanche photodiode were tested and compared using the phosphorescence decay time of cadmium tungstate (CdWO4). Effects originating from incipient detector saturation are revealed as a change i

Popular Abstract in Swedish Hjärt- kärlsjukdomar är den vanligaste dödsorsaken i Sverige. Den bakomliggande orsaken till de allra flesta fall av hjärt- kärlsjukdom är vad som i vardagligt tal kallas åderförkalkning. Den medicinska termen för åderförkalkning är ateroskleros. Ateroskleros är en inflammatorisk sjukdom i artärerna som orsakas av att LDL-partiklar, det så kallade onda kolesterolet, ansThe immune system is a promising target for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells (Tregs). Immunizations of hypercholesterolemic mice with oxidized L

Molecularly imprinted polymers (MIPs) targeting quercetin were prepared from 4-vinylpyridine and ethylene dimethacrylate (EDMA) under various solvent systems with the aim to form MIPs with high recognition for the quercetin molecule in aqueous systems at high temperature. A MIP prepared from the three-component solvent mixture of THF/H2O/MeOH showed potential in its application for the determinati

Digital controllers are traditionally implemented using periodic sampling, computation, and actuation events. As more control systems are implemented to share limited network and CPU bandwidth with other tasks, it is becoming increasingly attractive to use some form of event-based control instead, where precious events are used only when needed. Forms of event-based control have been used in prac

Lignocellulose-acting enzymes play a central role in the biorefinery of plant biomass to make fuels, chemicals and materials. These enzymes are often appended to carbohydrate binding modules (CBMs) that promote substrate targeting. When used in plant materials, which are complex assemblies of polymers, the binding properties of CBMs can be difficult to understand and predict, thus limiting the eff

In model organisms, thousands of genes differ in expression between females and males. It is not known if differences on a similar scale are found in humans nor how this relates to disease. However, in allergic disease gender differences in the levels of both inflammatory cells and proteins have been shown. In this study, we found lower nasal fluid allergen-specific IgE in women than men with seas

The jet energy scale (JES) and its systematic uncertainty are determined for jetsmeasured with the ATLAS detector using proton-proton collision data with a centre-of-mass energy of root s = 7 TeV corresponding to an integrated luminosity of 4.7 fb(-1). Jets are reconstructed from energy deposits forming topological clusters of calorimeter cells using the anti-kt algorithmwith distance parameters R

Markets, especially those for ‘fictitious’ commodities, are not the simple result of the gradual extension of exchange relations but social and political constructs. This paper discusses the socio-historical development of carbon markets and their application in the EU against the background of a Polanyian ‘double movement’: the reembedding of labour, money and land into social ties in the post-wa

The Third International Society of Blood Transfusion Workshop on Molecular Blood Group Genotyping was held in 2008, with a feedback meeting at the International Society of Blood Transfusion Congress in Macao SAR, China. Thirty-three laboratories participated, eight less than in 2006. Six samples were distributed: sample 1 representing DNA from a sample referred because of abnormal serological resu

BACKGROUND: Understanding the role that urologic disease plays within central Haiti could lead to the development of sustainable and regionally appropriate urologic care. We aim to document the prevalence of urologic surgical disease presenting for treatment in central Haiti. METHODS: The present study is based on a retrospective review of surgical case logs at five Partners in Health and Zanmi La

In this work the design of an experimental test Platform analysis of the mechanical behavior of car seats during passenger ingress and egress is presented. This development has been performed in two steps: the first Step is data acquisition. by means of a mat sensorized with a pressure gauge net and a photogrammetry system so as to acquire the movements performed by a human during ingress and egre