Lymphocyte lineage specification and commitment requires the activation of lineage-specific genes and repression of alternative lineage genes, respectively. The mechanisms governing alternative lineage gene repression and commitment in lymphocytes are largely unknown. In this study, we demonstrate that Ezh2, which represses gene expression through methylation of histone 3 lysine 27, was essential

Hur kan det komma sig att faktaresistensen exploderar i takt med coronautbrottet? Enligt sociologiprofessor Mikael Klintman är svaret glasklart. Vet du bäst själv? Läs inte det här.

The use of public demand to spur innovation has recently seen a very significant in-crease in political support. Such a policy promises improvement of public services on all state levels, combined with a contribution to innovation dynamics. It has become clear that strong efforts are needed to mobilise procurement at all state levels for inno-vative markets. These efforts need to be based on a bet

The process of transforming the industrial economy into a society largely based on the production and dissemination of information and knowledge has widespread implications for cities and regions as well as organisations and individuals. And while the economy is increasingly global, the differences in economic development between cities and regions will not necessarily disappear. Indeed, the diver

Public Technology Procurement and Innovation studies public technology procurement as an instrument of innovation policy. In the past few years, public technology procurement has been a relatively neglected topic in the theoretical and research literature on the economics of innovation. Similarly, preoccupation with `supply-side' measures has led policy-makers to avoid making very extensive use of

This contribution aims to deal with innovation policy from the perspective of the systems of innovation approach. The intention is to address basic principles related to national, regional or local as well as sectoral systems of innovation and the policy implications emerging from these. Hence, there will be a very strong emphasis on policy in what follows. However, it is essential, of course, tha

The focus of this study is on product innovations done by firms (establishments) and the collaborations they enter into with other firms and organizations in carrying out this activity. The theoretical framework combines innovation theories with the literature on regional innovation systems, industrial districts/clusters and knowledge-based economies. Empirically we have investigated the frequency

Public procurement represents a very large share of most economies worldwide. Besides its direct purchasing power, public procurement has an enormous potential to become one of the most important mission-oriented policy instruments in the context of the Sustainable Development Goals. The paper argues that the key to achieve more innovations when pursuing public procurement is to describe problems

There are signs of increasing protectionism in the world. Foreign direct investment regimes are in many countries gradually shifting away from the past policies of providing incentives to attract foreign multinational firms. Instead, various new regulations are implemented to provide the ability of host country to stop foreign acquisitions of domestic firms. This article examines the development o

Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. The 5-year survival rate remains less than 10% for all stages. One important unmet clinical need is