The use of public demand to spur innovation has recently seen a very significant in-crease in political support. Such a policy promises improvement of public services on all state levels, combined with a contribution to innovation dynamics. It has become clear that strong efforts are needed to mobilise procurement at all state levels for inno-vative markets. These efforts need to be based on a bet

The process of transforming the industrial economy into a society largely based on the production and dissemination of information and knowledge has widespread implications for cities and regions as well as organisations and individuals. And while the economy is increasingly global, the differences in economic development between cities and regions will not necessarily disappear. Indeed, the diver

Public Technology Procurement and Innovation studies public technology procurement as an instrument of innovation policy. In the past few years, public technology procurement has been a relatively neglected topic in the theoretical and research literature on the economics of innovation. Similarly, preoccupation with `supply-side' measures has led policy-makers to avoid making very extensive use of

This contribution aims to deal with innovation policy from the perspective of the systems of innovation approach. The intention is to address basic principles related to national, regional or local as well as sectoral systems of innovation and the policy implications emerging from these. Hence, there will be a very strong emphasis on policy in what follows. However, it is essential, of course, tha

The focus of this study is on product innovations done by firms (establishments) and the collaborations they enter into with other firms and organizations in carrying out this activity. The theoretical framework combines innovation theories with the literature on regional innovation systems, industrial districts/clusters and knowledge-based economies. Empirically we have investigated the frequency

Public procurement represents a very large share of most economies worldwide. Besides its direct purchasing power, public procurement has an enormous potential to become one of the most important mission-oriented policy instruments in the context of the Sustainable Development Goals. The paper argues that the key to achieve more innovations when pursuing public procurement is to describe problems

There are signs of increasing protectionism in the world. Foreign direct investment regimes are in many countries gradually shifting away from the past policies of providing incentives to attract foreign multinational firms. Instead, various new regulations are implemented to provide the ability of host country to stop foreign acquisitions of domestic firms. This article examines the development o

Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. The 5-year survival rate remains less than 10% for all stages. One important unmet clinical need is

The EEG spectral power in 4 frequency ranges (8-13, 15-25, 25-35, and 35-45 Hz) was studied during mental rotation of two- and three-dimensional objects. Only those EEG segments were analyzed which corresponded to the tasks with similar time of solving. The EEG spectral power of the alpha range was higher under control conditions than during task solving. The spectral power in the range of 15-45 H

The stages of mental rotation of complicated three-dimensional figures were studied using the intracortical interaction mapping. The role of the parietal areas in the mental rotation was shown. The frontal, central and the right temporal areas are involved in the prerotation setup. Both frontal areas and the left temporo-parieto-occipital areas participate in decision making and verbal response. I

Introduction: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2 (COX-2), which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (1

Over the past few decades, the automotive industry has increasingly looked towards increasing the efficiency of the internal combustion engine to meet more stringent emission norms and as a measure to meet demands for improved air quality in cities. One method to improve the internal combustion engine efficiency is to recover some of the energy lost to the coolant and the exhaust using a secondary

Introduction: Detection of circulating tumour cells (CTCs) in peripheral blood has an established prognostic significance in patients with metastatic breast cancer. Change in the number of detected CTCs is also an indication of response to therapy. Characterisation of CTCs could provide easily accessible treatment predictive information of present cancer cells within the patient and could reveal i

The impairment of multisensory integration in schizophrenia is often explained by deficits of attentional selection. Emotion perception, however, does not always depend on attention because affective stimuli can capture attention automatically. In our study, we specify the role of attention in the multisensory perception of emotional stimuli in schizophrenia. We evaluated attention by interference

Visual integration between target and irrelevant features leads to effects of irrelevant feature congruency (Stroop) or variation (Garner) on target classification performance. Presenting closed geometrical shapes as stimuli, we obtained Stroop and Garner effects of one part of their contour on another, in response times and error rates. The correlates of these effects in brain activity were obser

We used high-density event-related potentials (ERP) in a modified flanker paradigm to study the role of anticipated action consequences in action planning and the role of anticipation in the perception of action consequences. Prior to the experiment, participants were trained to classify target letters in a four-alternative forced-choice task; another letter was presented as an effect following ea