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Ibrutinib and rituximab versus immunochemotherapy in patients with previously untreated mantle cell lymphoma (ENRICH) : a randomised, open-label, phase 2/3 superiority trial

BackgroundIbrutinib, a Bruton tyrosine kinase inhibitor, prolongs progression-free survival when added to immunochemotherapy as first line treatment. The ENRICH trial compared the chemotherapy-free combination of ibrutinib and the anti-CD20 antibody rituximab (ibrutinib–rituximab) with standard immunochemotherapy (R-CHOP [rituximab–cyclophosphamide, doxorubicin, vincristine, and prednisolone] or b

Understanding how AI-enhanced search applications navigate digital grey zones in Sweden

AI-enhanced search applications are evolving rapidly, promising to answer complex queries with simple answers, but this creates new challenges on how users evaluate the information presented to them. This study investigates how four AI-enhanced search applications (ChatGPT, Gemini, Copilot and You.com) respond to questions about erectile dysfunction drugs in Sweden, which risks creating digital gr

Digital Transformations of Illicit Drug Markets: Reconfiguration and Continuity. By Tzanetakis Meropi and South Nigel (eds) (Emerald, 2023, 183pp., open access)

Digital Transformations of Illicit Drug Markets: Reconfiguration and Continuity is authored by leading experts in the field of illicit drug sourcing, who draw on their interdisciplinary backgrounds to illustrate how modern technologies are embedded within our social structures. Since the digital (r)evolution, the sourcing of illicit drugs now takes place through smartphones, encryption, social med

The role of politeness in Human-Robot Collaboration on comfortability and perceived social attributes of a robot

This thesis investigates the role of politeness in human-robot interaction and its effect on comfortability, social perception and collaboration. The study utilizes the humanoid robot Epi, which provides step-by-step instructions for two Lego-building tasks. Politeness was manipulated in the tasks so that the participants one time interacted with Epi while Epi used polite communication towards the

For Whom Do Unstructured Activities Matters? The Interaction Between Unstructured and Structured Activities in Delinquency and Cannabis Use : A National Self-Report Study

This study examines whether unstructured and structured activities interact in their association with delinquency and cannabis use. We hypothesize that unstructured activities are more strongly associated with delinquency and cannabis use for those who are less engaged in structured activities. Data are drawn from three nationally representative self-report studies conducted between 2005 and 2011

Överutnyttjandediskursen. En innehålls- och konsekvensanalys av diskursen kring överutnyttjande av sjukförsäkringen

Debatten om den höga svenska sjukfrånvaron har under senare år alltmer kommit att kretsa kring överutnyttjande och fusk. Det har etablerats en överutnyttjandediskurs, som bygger på föreställningen om en sjukfrånvaroepidemi i den arbetande befolkningen. I denna skrift görs en närgången och detaljerad analys av överutnyttjandediskursens innehåll och verklighetsbeskrivningar. Mer specifikt intressera

Maintaining teaching : exploring te(a)ch-abilities with actor-network theory

The thesis investigates everyday teaching with digital technology duringthe Covid-19 pandemic in 2020 and 2021. The pandemic was one of theworld’s largest disruptions to everyday education with both health andeducation at stake. With the pandemic control measures affecting uppersecondary education in Sweden, gathering in the classroom cannot betaken for granted and digital technologies accelerated

Diversion of methadone and buprenorphine by patients in opioidsubstitution treatment in Sweden : prevalence estimates and risk factors

Background: Diversion—patients who sell or share their medication—is a hotly debated but rela-tively unresearched phenomenon. We have investigated the prevalence of self-reported diversion ofmethadone and buprenorphine at OST programs in Sweden. We have also examined if demographic,treatment, and social factors can be associated with an increased risk of diversion. Methods: Structured interviews w

Non-prescribed use of methadone and buprenorphine prior to opioid substitution treatment : lifetime prevalence, motives, and drug sources among people with opioid dependence in five Swedish cities

Background: Opioid substitution treatment (OST) with methadone or buprenorphine is the most effective means of treating opioid dependence. If these substances are used by people who are not undergoing OST, they can however carry serious risks. This article examines the lifetime prevalence, motives, and drug sources for such use, as well as geographical differences in these variables. Methods: Stru

Long-term self-treatment with methadone or buprenorphine as a response to barriers to opioid substitution treatment : the case of Sweden

Background It is well known that illicit use of methadone and buprenorphine is common among people with an opioid dependence. Less notice has been taken of the fact that these substances are also used for extended periods of self-treatment, as a way of handling barriers to OST. In this study, motives for self-treatment are investigated, as well as attitudes and perceived barriers to OST among drug

Being a Parent to an Adult Child With Drug Problems : Negative Impacts on Life Situation, Health, and Emotions

This study is about the vulnerability of parents to adult children with drug problems. The study is based on a self-reporting questionnaire (n = 687) distributed to parents in Sweden via family member organizations, treatment centers, and online communities. Most parents reported extensive negative consequences on relationships, social life, and mental health due to their children’s drug problems.

Patient perspectives on depot buprenorphine treatment for opioid addiction - a qualitative interview study

Background: Recently developed buprenorphine depot injections have the potential to reduce risk for diversion and misuse, and to increase adherence with fewer visits for supervised intake. However, it is unclear how patients perceive this new form of medication. The purpose of this study was to explore patients experiences of depot injections and their reasons for continuing, discontinuing, or dec

User movies as a means of incorporating the knowledge and experience of users in web-based professional education

Combining video clips with forum discussions is a useful strategy in web-based distance learning. This article documents experiences from a project where specially recorded ‘user movies’ were used as a means of incorporating a user perspective in a web-based course on maintenance treatment of opiate addiction. User movies can help solve two common pedagogical challenges in distance learning. First