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Recovery, Functional Status, and Health-Related Quality of Life Status up to 4 Years after First-Ever Stroke Onset : A Population-Based Study

Background: Stroke is a leading cause of acquired disability in adults worldwide, and the burden of stroke is projected to increase. Current long-term stroke outcome data including functional status, activity, and participation limitations as well as information on health-related quality of life (HRQoL) are vital for future rehabilitation and resource planning of stroke survivors. Methods: First-e

Mapping the Past : Geographically Linking an Early 20th Century Swedish Encyclopedia with Wikidata

In this paper, we describe the extraction of all the location entries from a prominent Swedish encyclopedia from the early 20th century, the Nordisk Familjebok 'Nordic Family Book.' We focused on the second edition called Uggleupplagan, which comprises 38 volumes and over 182,000 articles. This makes it one of the most extensive Swedish encyclopedias. Using a classifier, we first determined the ca

The Use of COVID-19 Mobile Apps in Connecting Patients with Primary Healthcare in 30 Countries: Eurodata Study

Background: The COVID-19 pandemic has necessitated changes in European healthcare systems, with a significant proportion of COVID-19 cases being managed on an outpatient basis in primary healthcare (PHC). To alleviate the burden on healthcare facilities, many European countries developed contact-tracing apps and symptom checkers to identify potential cases. As the pandemic evolved, the European Un

The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas

Little is known about risk factors for central nervous system (CNS) relapse in mature T-cell and natural killer cell neoplasms (MTNKNs). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at the highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relaps

A Mitochondrial Basis for Heart Failure Progression

In health, the human heart is able to match ATP supply and demand perfectly. It requires 6 kg of ATP per day to satisfy demands of external work (mechanical force generation) and internal work (ion movements and basal metabolism). The heart is able to link supply with demand via direct responses to ADP and AMP concentrations but calcium concentrations within myocytes play a key role, signalling bo

Cutibacterium and Staphylococcus dysbiosis of the skin microbiome in acne and its decline after isotretinoin treatment

Background: Acne vulgaris is a multifactorial disease of the pilosebaceous unit of human skin. Previous studies have identified an acne-associated dysbiosis of the skin microbiome. Objectives: This dysbiosis was mainly determined for Cutibacterium acnes. However, detailed analyses combining qualitative and quantitative aspects are scarce, also regarding the possible contribution of other skin bact

KnockoffHybrid : A knockoff framework for hybrid analysis of trio and population designs in genome-wide association studies

Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a

Sequential school choice with public and private schools

We investigate sequential two-stage admission systems with public and private schools. A sequential notion of truthfulness, called straightforwardness, is introduced. Contrary to one-stage systems, sequentiality leads to a trade-off between the existence of a straightforward equilibrium and non-wastefulness. We identify the unique set of rules for two-stage systems that guarantees the existence of

Cardiovascular risk factor assessment in late-onset seizures : A study protocol to assess the value of structured intervention

Objective: A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. We aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. The long follow-up needed to assess s

“Mum Helps Me When the Internet Messes Up…” : Accessibility of eHealth Services for People with Intellectual Disability

Many services have become digitized in society, including health services. Although there are many advantages to eHealth services, some segments of the population cannot reap those benefits. Objectives: This study aimed to: 1- describe how people with intellectual disability use the internet in Sweden; and 2- understand the nature of the contextual and personal barriers these users face when tryin

Attentaten mot Hitler

I det nazistiska Tyskland framställdes Adolf Hitler som en frälsargestalt. Trots den intensiva propagandan fanns det tyskar, varav flera var högt uppsatta militärer och diplomater, som betraktade Hitler och det nationalsocialistiska partiet som en fara för den tyska nationens fortlevnad. De hade avlagt en ed och svurit lojalitet mot Führern men de såg sig nödgade att begå högförräderi för att räd

Public opinion, racial bias and labour market outcomes in the USA

Here we study the role of negative shifts in public opinion in the economic lives of under-represented racial groups by investigating sudden changes in views towards Asian people following the anti-Chinese rhetoric that emerged with the COVID-19 pandemic, and associated changes in employment status and earnings in the US labour market. Using data from the Current Population Survey, we find that, u

P-wave indices predict efficacy outcomes in long-term flecainide treated patients with atrial fibrillation

Background/introductionFlecainide is a commonly used efficient antiarrhythmic drug against atrial fibrillation (AF). P-wave indices reflect the atrial substrate and can predict incident AF, but their role as predictors of treatment outcomes for flecainide-treated AF patients are unknown.PurposeTo assess if P-wave indices can predict efficacy outcomes in long-term flecainide treated AF patients.Met

Standardised and automated assessment of head computed tomography reliably predicts poor functional outcome after cardiac arrest : a prospective multicentre study

Purpose: Application of standardised and automated assessments of head computed tomography (CT) for neuroprognostication after out-of-hospital cardiac arrest. Methods: Prospective, international, multicentre, observational study within the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial. Routine CTs from adult unconscious patients obtained > 48 h

Solo utställning Färgfabriken - Joakim Sandqvist mottagare av Beckers konstnärsstipendium 2024

Press release:Joakim Sandqvist explores what influences our perception of the world and its objects – from concrete manipulation to cultural context. As an artist, he works with a wide range of media in a process where the material and its story is essential. Behind each work lies thorough research spanning over a long period, sometimes several years. The artistic work often begins with something

Reduced Intensity transplantation vs chemotherapy in CR1. A prospective, pseudorandomized study in 50–70 year old AML patients

The aim of this prospective, international multicenter, pseudorandomized study comparing RICT HCT to standard-of-care chemotherapy in intermediate- or high-risk AML patients 50–70 years using the donor versus no-donor concept. Part 1 included only patients with potential family donors (RD) at the date of HLA-typing of the first potential sibling or CR-date, if later. Part 2 allowed the inclusion o

Finotypic plasticity : Predator-induced plasticity in fin size, darkness and display behaviour in a teleost fish

Fish fins are remarkable devices of propulsion. Fin morphology is intimately linked to locomotor performance, and hence to behaviours that influence fitness, such as foraging and predator avoidance. This foreshadows a connection between fin morphology and variation in predation risk. Yet, whether prey can adjust fin morphology according to changes in perceived risk within their lifetime (a.k.a. pr

Compact snapshot hyperspectral camera for ophthalmology

Hyperspectral imaging is an emerging technique that allows measurement of spectral absorption at each point of a scene, thus offering the capability to identify and characterize important biomarkers for clinical practice and therapeutic research, as well as enhancing image identification of important structures. So far, few hyperspectral cameras have been used for retinal scanning because of the n