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En märklig sak

Swedish translation of the poetry collection "The Curious Thing" (2021)

Free Will and the Tragic Predicament : Making Sense of Williams

This chapter presents an interpretation of Bernard Williams’s significant and substantial contributions on the topic of free will and moral responsibility. Williams’s fundamental objective, it is argued, is to vindicate moral responsibility by way of freeing it from distortions and misrepresentations imposed on it by “the morality system.” Although his earlier work is primarily concerned with the

Characterization of filamentous cyanobacteria and their effect on slow sand filters

Safe and clean drinking water delivery is challenged by climate change, as elevated temperatures can promote the growth of pathogens and other detrimental microorganisms. The microbial processes underlying drinking water production in slow sand filters (SSFs) are largely uncharacterized, limiting the possibilities of improving this technology. Periodical clogging, potentially by microbes, disrupts

Decreased spermatogonial numbers in boys with severe haematological diseases

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi a

Kliniskt beslutsstöd för opioidnedtrappning i öppenvård vid långvarig smärta : Utarbetat efter klinisk studie TOPIO för användande företrädesvis i smärtvård och primärvård

BakgrundLångvarig behandling med opioida läkemedel, här definierat som> 3 månader, på indikation långvarig icke-malign smärta är vanligt förekommande i smärtvården. Vid undersökningar i Lund och Linköping har noterats att ungefär en tredjedel av populationen vid smärtklinikerna exponeras för opioidbehandling, trots avsaknad av evidens och samtidigt väl kända risker med behandlingen. Nedtrappning a

Integrating a life course perspective in work environment and health research : empirical challenges and interdisciplinary opportunities

A healthy working life is fundamental for individuals and society. To date, increasingly research connects the earlier, pre-working life to later working life experiences and beyond, recognizing that a worker’s health and exposure starts before the working life begins. The research, however, often lacks a fundamental understanding of (i) the underlying mechanisms and pathways accounting for differ

Postoperative morbidity following Hartmann's procedure in comparison to anterior resection and abdominoperineal resection for rectal cancer—a population-based study

Aim: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. Methods: All patients operated for rectal cancer, tumour height

The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis

Introduction: Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known as GB1211) is a novel orally active galectin-3 small molecule inhibitor that has high affinity for galectin-3 (human KD = 25 nM; rabbit KD = 12 nM) and high oral bioavailability in rabbits and man. In this study the efficacy of

The Gaia -ESO Survey : No sign of multiple stellar populations in open clusters from their sodium and oxygen abundances

Context. The light element (anti-)correlations shown by globular clusters (GCs) are the main spectroscopic signature of multiple stellar populations. These internal abundance variations provide us with fundamental constraints on the formation mechanism of stellar clusters. Aims. Using Gaia-ESO, the largest and most homogeneous survey of open clusters (OCs), we intend to check whether these stellar

"Pingstväckelsens verklige apologet" : G. E. Söderholms apologetiska skriftställande 1920-1940. Kyrkohistorisk fältkamp och religiöst historiebruk inom den tidiga svenska pingströrelsen

This article is a study of G. E. Söderholm as apologetic writer of the early Swedish Pentecostal movement during the period 1920-1940. It investigates how Söderholm through the symbolic capital his status as a former vicar in the Swedish state church generated and through the use of historical writing defended the Pentecostal movement from polemic academic scholarship about the movement and from c

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A correct diagnosis and treatment of fingertip- and nail injuries, commonly seen in the emergency room, is crucial. Insufficient treatment can result in long-term complications, including finger dysfunction and dysaesthesia, nail deformity, infection, or pain. These remaining problems may induce severe impairment of the quality of life of the patient. This review summarises the diagnosis and treat

Alcohol intake and endogenous sex hormones in women : Meta-analysis of cohort studies and Mendelian randomization

Background: The mechanisms underlying alcohol-induced breast carcinogenesis are not fully understood but may involve hormonal changes. Methods: Cross-sectional associations were investigated between self-reported alcohol intake and serum or plasma concentrations of estradiol, estrone, progesterone (in premenopausal women only), testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

The antibody response to SARS-CoV-2 shows biased immunoglobulin heavy chain variable (IGHV) gene usage, allowing definition of genetic signatures for some classes of neutralizing antibodies. We investigated IGHV gene usage frequencies by sorting spike-specific single memory B cells from individuals infected with SARS-CoV-2 early in the pandemic. From two study participants and 703 spike-specific B