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The metabolism of drugs in the brain is difficult to study in most species because of enzymatic instability in vitro and interference from peripheral metabolism in vivo. A locust ex vivo model that combines brain barrier penetration, efflux, metabolism, and analysis of the unbound fraction in intact brains was evaluated using known drugs. Clozapine was analyzed, and its major metabolites, clozapin
A certain formalization of Analogical Morphology is shown to be undecidable by reduction of Post's Correspondence Problem.
In a situation when radionuclides accidentally or deliberately are dispersed in the environment, there is a need for rapid investigation of the internal contamination in exposed individuals. In this work, the possibilities of visualising and quantifying uptakes of different radionuclides in the lung region of an adult individual using gamma camera systems have been examined, mainly on a two-headed
Den mänskliga intelligensen går inte att isolera till enbart hjärnans aktiviteter. Tanken gror och frodas i social gemenskap och kultur. Men var finns då själen? Filosofen Ingar Brinck funderar kring den amerikanske komplexitetsforskaren John L Castis bok The Cambridge Quintet.
Artikeln diskuterar problematiken kring att få studenter med olika nivå av förförståelse att ta till sig och implementera teori och metod i de egna masteruppsatserna. Som en möjlig lösning för att möta studentgruppens skiftande behov föreslås en kursdesign med stort inslag av så kallat forskningsbaserat lärande (IBL).
This paper contains a simplified framework for the analysis of sequences of images taken by uncalibrated cameras. It is assumed that the correspondences between the points in the different images are known. Corresponding points in a sequence of n images are related to each other by a fixed n-linear form. This form is an object invariant property, closely linked to the motion of the camera relative
The right to water has been recently recognized as a fundamental human right by the United Nations, thereby clarifying its status as ‘legally binding’, making it ‘justiciable’ and enforceable. This development has been heralded as a key that holds great potential to change the lives of the billions who still lack access to clean water. Many of those deprived of enjoyment of the right are children,
In the present investigation, we sought to refine the classification of urothelial carcinoma by combining information on gene expression, genomic, and gene mutation levels. For these purposes, we performed gene expression analysis of 144 carcinomas, and whole genome array-CGH analysis and mutation analyses of FGFR3, PIK3CA, KRAS, HRAS, NRAS, TP53, CDKN2A, and TSC1 in 103 of these cases. Hierarchic
De utsatta bostadsområdena har under årens lopp varit föremål för ett varierande tvärvetenskapligt intresse med inriktning allt ifrån arkitektur, byggteknik och allmänna kommunikationer, till samhällsvetenskapliga studier av bostadspolitikens effekter: befolkningssammansättningar, demokrati, segregation, osv. Forskningsfältet är således i sig mångfasetterat och kan sägas spegla olika perspektiv på
Nucleoside analogues (NA) are prodrugs that are phosphorylated by deoxyribonucleoside kinases (dNKs) as the first step towards a compound toxic to the cell. During the last 20 years, research around dNKs has gone into new organisms other than mammals and viruses. Newly discovered dNKs have been tested as enzymes for suicide gene therapy. The tomato thymidine kinase 1 (ToTK1) is a dNK that has been
