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Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic for chronic migraine. Curiously, inhibition of neurokinin receptor 1 (NK1R) failed to alleviate acute migraine attacks in clinical trials, and th

BACKGROUND: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. METHODS AND RESULTS: We conducted a case-cohort study involving 10 529 incide

New temperature scales and remarkable differences from bulk properties have increasingly placed the surfaces of strongly correlated f materials into the focus of research activities. Applying first-principles calculations and angle-resolved photoelectron spectroscopy measurements, a strong Rashba effect and spin-split surface states at the CeIn surface of the heavy-fermion superconductor CeIrIn5 a

Metal halide perovskites have received great attention in recent years, predominantly due to the high performance of perovskite solar cells. The versatility of the material, which allows the tunability of the bandgap, has led to its use in light-emitting diodes, photo, and X-ray detectors, among other optoelectronic device applications. Specifically in photodetectors, the tunability of the bandgap

Cathedral roofs are commonly used when constructing small houses in Sweden. In contrast to roof constructions with a cold attic, where frequent moisture damage has been noted, the cathedral roof is difficult to access for inspection. Furthermore, Swedish building regulations sets high demands regarding moisture safety, although there are no clear guidelines for their compliance. Hence, designing a

Conditions experienced early in development can affect the future performance of individuals and populations. Demographic theories predict persistent population impacts of past resources, but few studies have experimentally tested such carry-over effects across generations or cohorts. We used bumble bees to test whether resource timing had persistent effects on within-colony dynamics over sequenti

This work investigates the effectiveness of Collective intelligence (CI) in demand side management (DSM) in urban areas to cope with extreme climate events. CI is a form of distributed intelligence that emerges in collaborative problem solving and decision making. It is used in a simulation platform to control the energy performance of buildings in an urban area in Stockholm, through developing CI

Sexual dimorphism requires regulation of gene expression in developing organisms. These developmental differences are caused by differential expression of genes and isoforms. The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). However, few studies have described how these processes change across development. We compare the

The specific effects of administering live probiotics in the human gut are not well characterized. To this end, we investigated the immediate effect of Lactobacillus rhamnosus GG (LGG) in the jejunum of 27 healthy volunteers 2 h after ingestion using a combination of global RNA sequencing of human biopsies and bacterial DNA sequencing in a multi-visit, randomized, cross-over design (ClinicalTrials

BACKGROUND: Larotrectinib is a first-in-class, highly selective tropomyosin receptor kinase (TRK) inhibitor approved to treat adult and pediatric patients with TRK fusion-positive cancer. The aim of this study was to evaluate the efficacy and safety of larotrectinib in patients with TRK fusion-positive primary central nervous system (CNS) tumors.METHODS: Patients with TRK fusion-positive primary C

Open Government Data (OGD) is an important driver for open innovation among public entities. However, extant research highlights a need for improved feedback loops, collaboration, and a more demand-driven publication of OGD. In this study, we explore how public platform providers can address this issue by enabling collaboration within OGD ecosystems, both in terms of the OGD, and any related Open

Riktlinjer för Kungl. Konsthögskolans grafiska formgivning beskrivs i skriften Mellan sköldebrev och varumärkesmanual. Skriften är främst riktad till dig som arbetar med högskolans grafiska formgivning och kommunikation, men även till dig som har annan anknytning till verksamheten eller är intresserad av konstnärliga högskolors kommunikation med omvärlden.

We present a fully relational definition of inertial systems based in the No Arbitrariness Principle, that eliminates the need for absolute inertial frames of reference or distinguished reference systems as the ``fixed stars'' in order to formulate Newtonian mechanics. The historical roots of this approach to mechanics are discussed as well. The work is based in part in the constructivist perspect