Therapeutic macromolecules are internalized into the cell by either clathrin-mediated endocytosis (CME) or clathrin-independent endocytosis (CIE). Although some chaperone proteins play an essential role in CME (e.g. Hsc70 in clathrin uncoating), relatively few of these proteins are functionally involved in CIE. We previously revealed a role for the mitochondrial chaperone protein GRP75 in heparan

The aim of this article is to map and present professional and non-professional Latin American film-making that took place in Sweden from the early 1970s to the early 1990s. Most of the films from this period have been excluded from the established, canonical film history, both nationally and internationally. Another aim of the article is to argue for the importance of the concept of ‘minor cinema

Coprolites from the Early Cretaceous vertebrate bone-bed at Ariño in Teruel, Spain, were analyzed geochemically and palynologically. They contain various inclusions, such as small bone fragments, abundant plant remains, pollen, and spores. We attribute the coprolites to carnivorous dinosaurs based partly on their morphology together with the presence of bone fragments, and a high content of calciu

Odorant binding proteins (OBPs) are proposed to be directly required for odorant discrimination and represent potential interesting targets for pest control. In the notoriously agricultural pest Adelphocoris lineolatus, our previous functional investigation of highly expressed antennal OBPs clearly supported this viewpoint, whereas the findings of the current study by characterizing of AlinOBP11 r

Sufficient conditions for stability of feedback interconnections of negative imaginary systems are derived via an integral quadratic constraint (IQC) approach. These extend existing results in the literature by exploiting the flexibility present at the static and infinite frequencies to reduce conservatism. Negative imaginary transfer functions with poles on the imaginary axis are accommodated usi

Monitoring vegetation gross primary production (GPP) is required for both carbon balance studies and early warning systems aiming to detect unfavorable crop and pasture conditions. This manuscript describes the assimilation of MODIS observations by a simple process model, fed by meteorological data (temperature, incident radiation and rainfall) and linked with a canopy reflectance model, to estima

This work provides the first morphological analysis (both at gross and fine level) of the antennal structures in the genusElater (Coleoptera, Elateridae). The typology, number and distribution patterns of the antennal sensilla in the rare saproxylicElater ferrugineus (both male and female) were studied using scanning electron microscopy (SEM). The serrate antennae ofE. ferrugineus consisted of a s

BACKGROUND AND PURPOSE: Genome-wide association (GWA) studies have identified a few risk loci for ischaemic stroke, but these variants explain only a small part of the genetic contribution to the disease. Coding variants associated with amino acid substitutions or premature termination of protein synthesis could have a large effect on disease risk. We performed an exome array analysis for ischaemi

OBJECTIVE: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes.METHODS: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p < 1

We aimed to establish whether recall of elements of the neurological examination can be improved by use of a simple patient assessment score. In a previous study we demonstrated that in-patients referred to neurology at two United Kingdom (UK) hospitals were not fully examined prior to referral; we therefore designed a larger quality improvement report with 80% power to detect a 10% increase in te

BACKGROUND: As many as 88% of heart transplant recipients (HTRs) suffer from psychological distress. Both psychosocial factors and physical health are associated with increased psychological distress. However, the causes and impacts of psychological distress are unclear. HTRs strive for a sense of control over their health and daily lives in order to improve their psychological well-being. Perceiv

Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary for instructing red blood cell (RBC) development remains undefined. We employed a screen for transcription factors allowing direct lineage reprograming from fibroblasts to induced

A new product, the surface emissions trap (cTrap), a device developed to stop and bind emissions effectively while having virtually no resistance to water vapor, was installed on a PVC flooring in a school with IAQ complaints. After the installation air concentrations of 2-ethylhexanol decreased rapidly and staff and students reported a considerably improved perceived IAQ. The amounts of 2-ethylhe

AIMS: The aims of this study were two-fold: to develop the concept analysis by Allvin et al. from lung recipients' perspective of their post-transplant recovery process and to identify the recovery trajectories including critical junctions in the post-transplant recovery process after lung transplantation.BACKGROUND: Lung transplantation is an established treatment for patients with end-stage lung

Several studies have shown associations between shorter telomere length in blood and weakened immune function, susceptibility to infections, and increased risk of morbidity and mortality. Recently, we have shown that malaria accelerates telomere attrition in blood cells and shortens lifespan in birds. However, the impact of infections on telomere attrition in different body tissues within an indiv

From 1950 until 1975 approximately 1.3 million apartments were built in Sweden. Now, a considerable part of these are in need of renovation. This paper is part of an evaluation of a new DCV system developed especially for the renovation of these houses. The DCV automatically regulates the air change rate for each dwelling based on measurements of the indoor air. One of the measured parameters is t

Evaluating the performance of retrofitted buildings for future climatic conditions can be a challenging task since different scenarios and uncertainties exist both for retrofitting of buildings and for future climate. This paper evaluates the energy performance of four retrofitting measures - applied to the building envelope - of the residential building stock in Gothenburg, Sweden. The energy eff

To meet EU energy and climate targets, energy efficiency of the existing building stock must be drastically improved. Within IEA EBC Annex 56 one of the best practice examples of energy renovations is a group of multi-family buildings in Sweden, recently thoroughly renovated. For this group of buildings the residents' perception of renovations and appraisal of implemented measures were captured by

The present study is divided in two differentiable but conceptually interrelated sections. Within the first section (Chapters I, II, and III), the focus is on the assessment of the argumentative logic behind the multiculturalist proposal for equally divided societies, among equally positioned ethno-cultural groups. A critical and analytical review of the multiculturalist argumentative construction