Although currently available antimuscarinic agents are the standard of care for overactive bladder (OAB), they are limited by certain side effects, particularly dry mouth and constipation. Research aimed at discovering new therapies for OAB has resulted in the identification of some promising drugs. Investigations of pharmacologic targets in the central nervous system (CNS) have yielded encouragin

Expression of human leukocyte antigen (HLA) class II molecules on islet endothelial cells is a central vascular event in the pathogenesis of Type 1 diabetes. Previous studies demonstrated the ability of other vascular endothelial cells to express HLA and thereby to process islet autoantigens on their surface. We investigated whether the HLA-DQ2/8 genotype, which confers the highest risk for Type 1

This article analyses existing small-scale wind farms located in India as hypothetical projects implemented under the Clean Development Mechanism (CDM). It addresses them from three different viewpoints (sustainable development, financial feasibility and institutional conditions), focusing mostly on identifying the smallest capacities and lowest performances at which these cases may become attract

The purpose of this article is to examine the effects of European integration on the location of investments by Swedish multinational corporations (MNCs). Evidence is presented about the extent to which European integration has attracted investment by Swedish MNCs, and whether foreign direct investment (FDI) is being undertaken at the expense of home country investment. In the empirical analysis,

This paper focuses on the use of material planning methods to control material flow to inventories of purchased items. The first sub-objective is to evaluate the perceived planning performance of material planning methods used to control material flows in different inventory types in manufacturing and distribution companies. The second sub-objective is to evaluate the difference in perceived plann

The interactions between herbivorous insects and their host plants have been central in generating diversification in both groups. We used a community of four yucca moth species, monophagous on the host plant Hesperoyucca whipplei (Agavaceae), to examine how the type of interaction and where insects feed within a plant influence phylogeographic structure of herbivorous insects. These four species

Inactivation of the perlecan gene leads to perinatal lethal chondrodysplasia. The similarity to the phenotypes of the Col2A1 knock-out and the disproportionate micromelia mutation suggests perlecan involvement in cartilage collagen matrix assembly. We now present a mechanism for the defect in collagen type II fibril assembly by perlecan-null chondrocytes. Cartilage perlecan is a heparin sulfate or

Total normothermic venoarterial bypass was established in 6 healthy pigs over a period of 18 hours. A heparin-coated closed extracorporeal system was used and no heparin was administered systemically. During the bypass period the main pulmonary artery was occluded and the heart was maintained in a beating state. All the animals maintained stable hemodynamics and normal blood gases during the entir

The polygyny threshold model was introduced in the 1960s in order to explain why females in some species choose to mate vith already mated males. Since then, a number of complementary or alternative hypotheses have been suggested. By using a hierarchical testing approach Searcy and Yasukawa (1989) organised the models that proposed to explain the maintenance of territorial polygyny. Here, I point

Objective: To assess factors for progression in the Early Manifest Glaucoma Trial (EMGT), including the effect of EMGT treatment. Setting/Participants: Two hundred fifty-five open-angle glaucoma patients randomized to argon laser trabeculoplasty plus topical betaxolol or no immediate treatment (129 treated; 126 controls) and followed up every 3 months. Methods: Progression was determined by perime

According to mechanobiologic theories, persistent intermittent mechanical stimulation is required to maintain differentiated cartilage. In a rat model for bone repair, we studied the fate of mechanically induced cartilage after unloading. In three groups of rats, regenerating mesenchymal tissue was submitted to different loading conditions in bone chambers. Two groups were immediately killed after

From 1990 to 1997, 113 eligible patients with classical osteosarcoma received neo-adjuvant chemotherapy consisting of high-dose methotrexate, cisplatin and doxorubicin. Good histological responders continued to receive the same therapy postoperatively, while poor responders received salvage therapy with an etoposide/ifosfamide combination. With a median follow-up of 83 months, the projected metast

The envelope process is an analytical tool often used to study extremes and wave groups. In an approach to approximate the first passage probability for the underlying response the average number of envelope crossings is used to obtain an upper bound. In the first part of the paper, we review the approach as well as give a brief account of the previous results with some focus on the contribution

We have studied experimentally and theoretically high-order harmonic generation using a laser field with a time-dependent ellipticity. We show that the harmonic emission can be confined into a narrow temporal window, in which the fundamental polarization is quasi-linear. This allows a single attosecond pulse (200 as) with a fundamental field obtained from 10 fs pulse to be generated.

Directional selection was relatively frequent, and in some instances intense, during a three-year study of a pheasant population. The pheasant is a polygynous species. In addition to weight, tarsus length and wing length, which were studied in both sexes, three beak characters were measured in females, and tail and spur length in males. Both univariate and multivariate techniques were used to esti

A scheme for backward retrieval in optical quantum memories in which information is stored in collective states of an extended resonant atomic ensemble is developed such that phase conjugation can be implemented by application of an external nonuniform electric (magnetic) field without use of coherent exciting pulses. The possibilities of realizing such a scheme using resonant solid-state material

Using phase plane analysis we show that within the framework of linear water wave theory the particle paths in a deep-water wave are not closed: there is a forward drift over a period, which decreases with greater depth.