This paper reviews research on child L2 French (cL2) published since 2000 with a focus on research areas and methodology in a broad sense. The aim of the review is to identify methodological trends in the research, to exemplify, and to provide a discussion of prominent features. The review shows that research on cL2 French has mainly focused on the acquisition of morphosyntax based on oral product

The separation of multiple transmit waveforms with time and frequency synchronization constitutes a considerable challenge for multiple-input multiple-output (MIMO) synthetic aperture radar (SAR) systems. It is well-known that aliased signal returns may be separable by digital beamforming (DBF) on receive in elevation. However, the current orthogonal-waveform beamforming schemes significantly incr

Background: The diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) may impact mental health. We investigated the long-term risk of psychiatric disorders among survivors of ALL in a population-based cohort study. Methods: We identified patients diagnosed with ALL in Denmark and Sweden before age 20 during 1982–2008. Survivors of ALL (n = 2026), their siblings (n = 3027), and po

The interest in galectin-3 as a drug target in the cancer and fibrosis space has grown during the past few years with several new classes of compounds being developed. The first orally available galectin-3 inhibitor, GB1211 (h-galectin-3 Kd = 0.025 μM), is currently in phase 2 clinical trials. Due to structural differences between human and mouse galectin-3 a significant reduction in mouse galecti

Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P

This paper introduces a work-in-progress devoted to analysing the architectural design, public-performative functionality, and cultural-political semiotics of the Safra Square (ספרא כיכר, Kikar Safra) and City Hall complex, Western Jerusalem. Built around the historic Town Hall of the British Governate, and inaugurated in 1993, the City Hall complex is strategically located along the bustling pede

Cyclase-associated proteins (CAPs) are evolutionary conserved G-actin-binding proteins that regulate microfilament turnover. CAPs have a modular structure consisting of an N-terminal adenylate cyclase binding domain, a central proline-rich segment, and a C-terminal actin binding domain. Protozoan parasites of the phylum Apicomplexa, such as Cryptosporidium and the malaria parasite Plasmodium, expr

The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 a

Opportunistic mobile predators can adapt their behaviour to specific foraging scenarios, allowing them to target diverse prey resources. An interesting example is the harbour porpoise (Phocoena phocoena), a marine mammal with a huge energy demand feeding on a large variety of fish, squid and shrimps. Little is known about the foraging behaviour of harbour porpoises, as observations of wild specime

Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case–control study was conducted from 1995 to 1997, including incident cases aged 35–69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cas

Objective: To systematically evaluate which lesion-based imaging features and methods allow for the best statistical prediction of poststroke deficits across independent datasets. Methods: We utilized imaging and clinical data from three independent datasets of patients experiencing acute stroke (N1 = 109, N2 = 638, N3 = 794) to statistically predict acute stroke severity (NIHSS) based on lesion v

Knowledge management is pivotal in innovation using mechanisms to facilitate knowledge exchange and learning among competitive tourism organisations and destinations. Nevertheless, both the tourism industry and its scholars have been slow to embrace the field leaving it relatively underdeveloped. Knowledge management, as a sequential process of capturing, developing, sharing, and leveraging from o