Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory lymphangiogenesis. In the mouse model of corneal allogeneic transplantation, galectin-8-induced

In this work we include electron-electron interaction beyond Hartree-Fock level in our non-equilibrium Green's function approach by a crude form of GW through the Single Plasmon Pole Approximation. This is achieved by treating all conduction band electrons as a single effective band screening the Coulomb potential. We describe the corresponding self-energies in this scheme for a multi-subband syst

Skogsekosystemet är ett av de viktigaste ekosystemen på jorden. Skogen förser oss med mycket som vi har nytta av, vilket numera ofta kallas ekosystemtjänster. Skogen reglerar och förser oss med många viktiga ekosystemtjänster, till exempel biodiversitet, skydd av mark och vatten, tillförsel av fiber, bränsle och andra skogsprodukter, klimatreglering samt sociokulturella värden och tjänster. ArealeThe forest ecosystem provides and regulates many important ecosystem services, such as soil and water protection, timber production, and climate regulation. It has been influenced by changes induced by humans, for example, our increasing demand for timber and bioenergy, the increase in nitrogen (N) deposition and CO2 concentrations due to industrialization, and climate change which has caused an i

A large number of medical examinations involve images in some way. Images can be used for diagnostics, follow-up studies and treatment planning. In this thesis mathematical methods have been developed and adapted in order to analyze medical images. Several applications for different imaging modalities have been studied and the usefulness of such methods is demonstrated.A complete system for detect

Using non-equilibrium Green's functions combined with many-body perturbation theory, we have calculated steady-state densities and currents through short interacting chains subject to a finite electric bias. By using a steady-state reverse-engineering procedure, the effective potential and bias which reproduce such densities and currents in a non-interacting system have been determined. The role o

Historisk-demografisk forskning är central för att förstå mänskliga beteenden och egenskaper genom historien, såsom fertilitet, dödlighet och migration. En väsentlig del inom historisk demografi är att utföra longitudinella analyser på mikronivå. Detta innebär att individer följs kontinuerligt över livscykeln utifrån demografiska händelser (födelse, giftermål, flyttningar och död) under flera geneHistorical demographic research is central to understanding past human behaviours and traits, such as fertility, mortality and migration. An essential part of historical demography is conducting longitudinal analyses at the micro-level, which involves the detailed follow-up of individuals over long time periods throughout their lives. By including the geographic context in such analyses, we can st

The polska, under lots of different spellings and titles, was the dominant music and dance repertoire in Sweden for nearly 300 years. The main purpose of this thesis has been to clarify some of the principal characteristics in both its dance and music forms. The thesis has both a historical and an ethnomusicological perspective and moves in the intersection between different types of traditional m

A number of behaviours influence health in a non-monotonic way. Physical activity and alcohol consumption, for instance, may be beneficial to one's health in moderate but detrimental in large quantities. We develop a demand-for-health framework that incorporates the feature of a physiologically optimal level. An individual may still choose a physiologically non-optimal level, because of the trade-

Myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U) are rare genetically heterogeneous hematologic diseases associated with older age and a poor prognosis. If the disease progresses into acute myeloid leukemia (AML), it is often refractory to treatment. To gain insight into genetic alterations associated with disease progression, whole exome sequencing and single nucleotide po