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Objective: The aim of this study was to assess the incremental cost-effectiveness of on-demand versus prophylactic hemophilia therapy in Iran from a third-party payers’ perspective.Methods: A retrospective chart review of twenty-five type A hemophiliacs who were treated in three hemophilia treatment centers was conducted. The patients were boys 0–9 years old receiving one of two treatments: (i) pr

The Permian-Triassic Boundary sequence at Çürük Dag, near Antalya, Turkey, begins with a major erosion surface interpreted as being the Late Permian lowstand, on which lies ca 0·4m of grainstone/packstone composed of ooids, peloids and bioclasts. Most ooids are superficial coats on fragments of calcite crystals presumed to be eroded from crystal fans which are no longer present. The erosion surfac

Background: The impact of surgical specialization on long-term survival in patients undergoing emergent colon cancer resections remains unclear. Method: A retrospective analysis was conducted on all patients who underwent emergent colon cancer resections at a secondary care hospital between 2010 and 2020. The most senior surgeon performing the procedures was classified as colorectal surgeon (CS) o

Background: CD40 agonists have the potential to enhance the efficacy of standard of care chemotherapy and to trigger antitumor immunity. Preclinical models indicate that the success of this approach depends on appropriate sequencing of chemotherapy with a CD40 agonist. Preliminary efficacy results from the OPTIMIZE-1 Phase II study (NCT04888312) combining mitazalimab (anti-CD40) with mFFX chemothe

Background The optimal strategy for initial treatment of acute occlusion of superior mesenteric artery (SMA) is debated. The aim of the study was to compare the effectiveness, timelines and outcomes of endovascular versus open surgical treatment in patients with acute SMA occlusion. This was a preplanned substudy of the prospective observational multicenter AMESI (Acute MESenteric Ischaemia) study

Flat bands can induce strong electron correlation effects that help stabilize both magnetic and superconducting states. Here, we carry out angle-resolved photoemission spectroscopy and density functional theory calculations to study the electronic structure of the Co-pnictides CaCo2As2 and LaCo2P2. We find that the kz Fermi topology of ferromagnetic LaCo2P2 is markedly two-dimensional, while the a

β-Alanine synthase (βAS), which is a dizinc metalloenzyme, catalyzes the irreversible hydrolysis of N-carbamyl-β-alanine (NCβA) to β-alanine. This enzyme has potential applications for β-amino acid production. Understanding the reaction mechanism and selectivity of βAS at atomic details can help design and engineer the enzyme for cascade biocatalysis. Here, the protonation states of two conserved

The end Permian negative δ13C excursion is well known but its cause and chronology are still in question. In an attempt to decipher the timing and reasons for this strong decrease, we established high-resolution sedimentological, biostratigraphical and carbonate carbon isotopic studies in four sections in Iran (Abadeh, Shareeza, Zal and Djulfa) and two in Oman (Wadi Sahtan). The position of the se

One of the major recent breakthroughs has been the discovery of the last major merger to happen in the history of the Milky Way. Around 10 Gyr ago, the galaxy Gaia Enceladus with an estimated ∼10% of the Milky Way mass, fell into the potential of our Galaxy, bringing a large amount of stars that can be identified through their unique chemical and kinematic signatures. Simulations have long predict

δ13C data from Tethyan sections provide evidence of profound changes in the carbon cycle during the Lower Triassic. Sections from the Panthalassa realm were investigated to establish whether these variations are also present there. In the Jurassic accretionary wedges in Japan, exotic blocks having a Panthalassan affinity, have been incorporated. The majority of the blocks are pelagic cherts but ra

6 evaporite samples from the latest Permian to the late Lower Triassic have been sampled at marine carbonate sections in the Southern Alps. The sulphur isotope ratio of the sulphate has been determined to learn about the changes of the marine δ34S ratio during the investigated period, as it is known from the literature that a profound change from depleted to heavily enriched δ34S values occurred w

Evolutionary transitions to nocturnality in bees are rare and recent, occurring independently across several families, with activity ranging from crepuscular to strictly nocturnal. Although the “enemy-free” and “competition-free space” hypotheses are often suggested as drivers, these remain little explored in bees. In sympatric diurnal and nocturnal carpenter bees, we show that in addition to temp

Research on birds suggests that extreme weather events during development may have long-lasting consequences on form and function. The underlying cellular mechanisms mediating such phenotypic effects are poorly studied. We raised Japanese quail in warm (30°C) or cold (10°C) temperatures from hatching until adulthood and then measured mitochondrial metabolism in intact blood cells at representative

In this work, we have studied how the choice of the continuous phase oils affects droplet-internal acoustic manipulation and mapped the acoustic properties of the selected oils to evaluate their compatibility with droplet acoustofluidic methods. The selection of continuous phase included hydrocarbon, fluorinated, and silicone oils. To map the acoustic properties of the oils, we measured their spee

Very few data on Early Triassic marine ostracods are available. In most of cases, the data concern the upper part of the Early Triassic. The çürük dağ section, located in the Western Taurides (Turkey), well stratigraphically constrained by conodonts and foraminifera, has been re-sampled for ostracod study. A significant fauna has been discovered in the Late Permian and the levels of the Earliest T

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr