Search results

The emergence of drug-resistant Gram-positive pathogens, particularlyStaphylococcus aureusandStreptococcus pyogenes, has driven the need for novel antimicrobial agents. This study explores 21 newly synthesized peptidomimetic analogues of cystatin C Nterminal fragment, designed to enhance bioactivity, solubility, and safety. These compounds were evaluated for antimicrobial potency, cytotoxicity, pr

The chromosomes of 13 primary and 4 secondary Rous sarcomas (RSV–SR) in the rat have been studied in fixations directly from the tumour. The general character of the chromosomal spectrum in the primary sarcomas was similar to that of the Rous sarcomas in the mouse and the Chinese hamster. However, normal diploid stemlines were considerably more frequent in the rat sarcomas; among the heteroploid s

A grazing-incidence Rowland spectrometer with a collimating element for resonant inelastic soft X-ray scattering at the Veritas beamline at MAX IV, Lund, Sweden, is presented. The instrument is designed to operate in the 250–950 eV range, providing >30000 resolving power in first order. The inherent temporal resolution of the delay-line detector enables time-resolved experiments on the 270 ps time

Beamline end-stations often require components to move along non-trivial multi-dimensional trajectories in order to fulfill experimental requirements. These trajectories can frequently be realised through well synchronized combined motion of multiple axes with single degrees of freedom, such as linear and rotational actuators. A good example of this is the SCANIA-2D (Segmented Crystal Analyzer wit

This viewpoint advocates for the inclusion of art in global health discourse and practice. We explore four areas in which art can be leveraged to improve global health: (1) to amplify disenfranchised voices, (2) to advance social justice activism, (3) to strengthen communities and individuals, and (4) to improve global health communication. Drawing on community-driven art initiatives, we argue for

We examine how the earlier introduction of compulsory school grades affects the likelihood of receiving a mental disorder diagnosis among Swedish adolescents. We exploit a school reform that shifted the introduction of grades from grade 8 to grade 6, resulting in first exposure to grading at different ages between cohorts. Our results show that girls exposed to earlier grading are more likely to b

Parents of children with disabilities may face higher labor-market penalties given the extra care and support required. Using Swedish administrative data, we focus on first-born children with Cerebral Palsy (CP) to estimate impacts on parental labor-market outcomes. We apply an event study approach to identify effects up to 10 years after the birth of the child. Our results show that employment an

OBJECTIVES: Loneliness and social isolation are major public health concerns that contribute to numerous health consequences. While many interventions effectively reduce loneliness and social isolation, their cost-effectiveness remain unclear. This study aimed to evaluate and consolidate evidence on the cost-effectiveness of interventions addressing loneliness or social isolation.METHODS: We condu

China’s “Ugly-Cute” Soft Power Wave: What’s Behind Its Explosive Popularity Surpassing Japan and South Korea?

Unsustainable resource flows and obscene inequalities are as inherent in the use of green technologies as in that of the fossil fuels they are meant to replace. The notion that the world economy is undergoing a green transformation is based on the illusion that renewable energy is replacing, rather than just adding to, fossil energy consumption. To move beyond this impasse, we must recognize that

Årets rapport innehåller totalt 15 rekommendationer inom tre områden: Kommunen arbetssätt, Naturbaserade lösningar och att Säkra energisystemet. Här presenteras förslagen i sammanfattad form och de mer detaljerade förslagen återfinns under respektive område i rapporten.1. En mer effektiv klimatanpassningRådet föreslår att kommunen bör utveckla arbetssätt för att främja en mer effektiv klimatanpass

This study explores the characteristics of individuals affiliated with violent extremist milieus in Sweden, focusing on far-right, far-left, and Islamic extremist milieus. Firstly, by using a compilation of law enforcement and other Swedish population registers, we describe these milieus along a range of demographic, socioeconomic, criminal, mental health, and familial indicators. We then compare

Background: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arreBackground: Biomarkers serve as a quantitative measure of brain injury and may predict cognitive outcome after cardiac arrest. This study investigates the association and predictive accuracy of acute changes in Alzheimer disease-associated biomarkers to cognitive outcome in cardiac arrest survivors.Methods: Retrospective study of the Target Temperature Management after Out-of-Hospital cardiac arre

Background: Many people ageing with late effects of polio (LEoP) experience new or increased impairments which could negatively influence daily life. Currently, there is limited knowledge how LEoP-related impairments change over time. Objectives: To assess how various self-reported impairments change over 10 years among people with LEoP, and explore factors associated with the changes. Methods: Th

Background: Portal vein embolization (PVE) may be used to induce hypertrophy of the future liver remnant (FLR) before major hepatectomy. The influence of hyperbilirubinemia on FLR hypertrophy after PVE is controversial. The aim of this study was to compare FLR hypertrophy after PVE between patients with and without elevated P-bilirubin. Materials/methods: This is a Scandinavian retrospective cohor

An Fe(III)-NHC complex has been employed for the green light driven catalysis of base-promoted homolytic aromatic substitution (BHAS) reactions. Tributylamine was used as a sacrificial electron donor, together with potassium carbonate as base in dimethyl sulfoxide as solvent. In contrast to previously studied photocatalysts, the excited Fe(III)-NHC complex is not reducing the arylhalide substrates

Background: Combination lipid-lowering therapy (LLT) after myocardial infarction (MI) achieves lower low-density lipoprotein cholesterol (LDL-C) levels and better cardiovascular outcomes vs statin monotherapy. As a result, global guidelines recommend lower LDL-C but, paradoxically, advise treatment through a stepwise approach. Yet the need for combination therapy is inevitable as <20% of patients