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Beneficial effect from a cognitive training programme on children with acquired brain injuries demonstrated in a controlled study

Primary objective: To test the effectiveness of a cognitive training programme in children and adolescents with attention and memory deficits after acquired brain injury (ABI). Research design: Randomized controlled study. Participants: Thirty-eight children with ABI, 9 - 16 years of age. Methods and procedures: The treatment group trained with the cognitive programme for 30 minutes per day intera

Estimation of the biomass and seasonal growth of external mycelium of ectomycorrhizal fungi in the field

In-growth mesh bags were used to quantify the production of external mycelium of ectomycorrhizal (EM) fungi in the field. Colonization of the mesh bags was followed by visual estimation of the amount of mycelium, and by measuring fungal biomarkers (the phospholipid fatty acid (PLFA) 18 : 2 omega6,9 and ergosterol). Mesh bags were placed inside and outside plots that were root isolated in order to

Restricted clinical efficacy of cyclosporin A on rat transient middle cerebral artery occlusion

The immunosuppressant cyclosporin A (CsA) has been shown to have neuroprotective action. The inhibition of both calcineurin activation and mitochondrial permeability transition pore (mtPTP) opening are considered the primary neuroprotective mechanisms of CsA. Here we have evaluated the effect of CsA on significantly reducing infarct size induced by transient middle cerebral artery occlusion (MCAO)

Study of a filtered flamelet formulation for large eddy simulation of premixed turbulent flames

Despite significant advances in the understanding and modelling of turbulent combustion, no general model has been proposed for simulating flames in industrial combustion devices. Recently, the increase in computational possibilities has raised the hope of directly solving the large turbulent scales using large eddy simulation (LES) and capturing the important time-dependant phenomena. However, th

Mast cells and biogenic amines in radiation-induced pulmonary fibrosis

Sprague-Dawley rats were exposed to a single X-ray dose of 30 Gy over the lungs and examined at 1-wk intervals during the following 3 to 8 wk. Mast cells were counted after specific staining with toluidine blue at a low pH and the mast-cell amines, histamine (Hi) and serotonin (5-HT), were measured using high-performance liquid chromatography. Irradiation induced pneumonitis followed by pulmonary

Value added: increasing the power to assess treatment outcome in joint haemorrhages

Subject reports of efficacy of treatment of haemophilia-related joint bleeding are by definition subjective, yet are often the primary outcome in studies comparing therapies. Verbal descriptors such as effective, partially effective, poorly effective, not effective are treated as dichotomous or categorical variables in analyses, lowering the statistical power relative to that which might be achiev

Platelets synthesize large amounts of active plasminogen activator inhibitor 1

Previous studies have suggested that plasminogen activator inhibitor 1 (PAI-1) released from platelets convey resistance of platelet-rich blood clots to thrombolysis. However, the majority of PAI-1 in platelets is inactive and therefore its role in clot stabilization is unclear. Because platelets retain mRNA and capacity for synthesis of some proteins, we investigated if platelets can de novo synt

Professions and the Pursuit of Transparency in Healthcare: Two Cases of Soft Autonomy

Contemporary professions are increasingly challenged to open up to scrutiny from the outside. Earlier research is focused on two main types of responses and consequences: colonization by a managerial logic of self-monitoring and decoupling of auditing and professional practice. his paper describes a different type of response which implies that professionals get actively involved in monitoring the

Smad7 promotes self-renewal of hematopoietic stem cells in vivo.

The Smad-signaling pathway downstream of the transforming growth factor–beta superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have blocked Smad signaling by retroviral gene transfer of the inhibitory Smad7 to muri

Limited male dispersal in a social spider with extreme inbreeding

Cooperatively breeding animals commonly avoid incestuous mating through pre-mating dispersal. However, a few group-living organisms, including the social spiders, have low pre-mating dispersal, intra-colony mating, and inbreeding. This results in limited gene flow among colonies and sub-structured populations. The social spiders also exhibit female-biased sex ratios because survival benefits to la

Validation of the use of Pap-stained vaginal smears for diagnosis of bacterial vaginosis

Papanicolaou-stained cervicovaginal smears (Pap smears) are used to screen for cervical cancer. Since there is a lack of consensus in published reports respecting the efficacy of Pap-stained smears in BV diagnostics, there is a need to validate their use for diagnosis of BV. Slides from the international BV00 workshop were Pap stained and independently analyzed by four investigators under a phase-

Assessing phonologies in bilingual Swedish-Arabic children with and without language impairment

Ten Swedish-Arabic children with severe language impairment (LI) and 10 matched controls were tested with Swedish and Arabic phonology tests. The children with severe LI displayed significantly more of both syntagmatic and paradigmatic processes in both languages. The results are also discussed in relation to monolingual children in Swedish and Arabic, both children with a normal language developm

Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility

Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at low expression levels. Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to deve