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The LISA project : opportunities and challenges of recycling automotive heat exchangers

A modern vehicle typically has up to ten different heat exchangers, ensuring prolonged technology life, improved performance, and passenger comfort. Heat exchangers for automotive applications are made of multilayer-clad brazed aluminium. They are mature products, having been used in passenger and commercial internal combustion engine vehicles for decades, and their use will continue in electrifie

Gepants

Calcitonin gene-related peptide (CGRP) was suggested to play an important role in primary headaches as far back as 1985 and has been confirmed as playing a significant role in migraine pathophysiology. CGRP receptor antagonists are becoming more and more important for treatment of acute migraine attacks and for prophylaxis of episodic and chronic migraine. The development of drugs that bind CGRP o

Can the internet based intervention 'strategies for empowering activities in everyday life' support people with cognitive difficulties to self-manage digital work and everyday life?

Background: Digital work can be cognitively challenging especially for people with cognitive difficulties. New occupational therapy interventions are needed to empower these persons to self-manage challenges in digital work and everyday life. To address this need, the internet-based intervention 'Strategies for Empowering Activities in Everyday Life' (SEE 2.0) was tested.Aim: To explore and descri

Gender differences in climate change denial in Sweden : the role of threatened masculinity

Previous research in the Western world shows that men are in general more likely than women to deny human-induced climate change or certain aspects of it. We hypothesize that threatened masculinity contributes to such gender differences in Sweden. Threatened masculinity refers to the perception that a man’s masculinity is being challenged, undermined, or devalued, often due to societal changes tha

Diffusion tensor imaging along the perivascular space : the bias from crossing fibres

Non-invasive evaluation of glymphatic function has emerged as a crucial goal in neuroimaging, and diffusion tensor imaging along the perivascular space (DTI-ALPS) has emerged as a candidate method for this purpose. Reduced ALPS index has been suggested to indicate impaired glymphatic function. However, the potential impact of crossing fibres on the ALPS index has not been assessed, which was the a

Carbon isotope stratigraphy and conodont biostratigraphy of the Furongian (upper Cambrian) Qingkeng Formation, Anhui Province, South China

We present a new carbon isotope chemostratigraphy for the upper Cambrian carbonate succession of the south Anhui Province, South China, based on new δ13Ccarb data and conodont records. Paraconodont assemblages in the lower part and euconodonts in the middle to upper part of the section were obtained from samples from the Qingkeng Formation. The paraconodont occurrences enable us to recognize the r

Ibuprofen for acute postoperative pain in children

BACKGROUND: Children often require pain management following surgery to avoid suffering. Effective pain management has consequences for healing time and quality of life. Ibuprofen, a frequently used non-steroidal anti-inflammatory drug (NSAID) administered to children, is used to treat pain and inflammation in the postoperative period.OBJECTIVES: 1) To assess the efficacy and safety of ibuprofen (

Inclusion, characteristics and methodological limitations of systematic reviews in doctoral theses: A cross-sectional study of all universities in Sweden

Abstract Intro A systematic review (SR) attempts to find, assess and summarize all the empirical evidence to answer a specific research question. We aim to explore to what extent reviews are included in doctoral theses from all universities with a medical faculty in Sweden, and to describe the type, topic and assess the methodological quality of the reviews. Methods Duplicate assessors independent

Inflammatory and subtype-dependent serum protein signatures predict survival beyond the ctDNA in aggressive B cell lymphomas

BackgroundBiological heterogeneity of large B cell lymphomas (LBCLs) is poorly captured by current prognostic tools, hampering optimal treatment decisions.MethodsWe dissected the levels of 1,463 serum proteins in a uniformly treated trial cohort of 109 patients with high-risk primary LBCL (ClinicalTrials.gov: NCT01325194) and correlated the profiles with molecular data from tumor tissue and circul

Translation and Linguistic Validation of the Multidimensional Dyspnoea Profile into Telugu in a Palliative Care Setting

Objectives: Dyspnea, or breathlessness, is a frequent and distressing symptom among patients with heart and lung diseases, particularly in advanced cancer stages, where it affects up to 90% of lung cancer cases. This symptom considerably diminishes quality of life, leading to physical deconditioning, increased levels of anxiety and depression, repeated hospitalizations, and elevated mortality rate

The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue

Background/objectives: Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced st

Improving the representation of hydrology in a terrestrial ecosystem model, with applications at catchment to global scales

Accurately representing and predicting hydrological processes in terrestrial ecosystems is crucial for understanding the impacts of global environmental change, particularly climate change. This doctoral thesis aims to advance the understanding of vegetation-hydrology interactions and provides new modelling approaches to enhance hydrological prediction abilities. The thesis is grounded in the eval

Potential alternative and novel biomarkers for paediatric MAFLD : exploratory evidence from a Chinese cohort

BACKGROUND: While the associations between pediatric non-obese metabolic dysfunction-associated fatty liver disease (MAFLD) and multiple diagnostic biomarkers are well-established, the role of a broader range of blood-based, urine-based, and body composition-based biomarkers for monitoring MAFLD are needed.METHODS: A pediatric cohort was established in Wuxi, China. We measured body composition bio