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A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Summary: The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. Introduction: Previous falls are a well-documented risk factor for s

Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Background: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuro

Measurement of the H→ γγ and H→ ZZ∗→ 4 ℓ cross-sections in pp collisions at √s=13.6 TeV with the ATLAS detector

The inclusive Higgs boson production cross-section is measured in the di-photon and the ZZ∗→ 4 ℓ decay channels using 31.4 and 29.0 fb - 1 of pp collision data respectively, collected with the ATLAS detector at a centre-of-mass energy of s=13.6 TeV . To reduce the model dependence, the measurement in each channel is restricted to a particle-level phase space that closely matches the channel’s dete

Towards a Global Plastics Treaty: Tracing the UN Negotiations

In 2022, the United Nations Environmental Assembly (UNEA) adopted resolution 5/14, giving mandate to UN Member States to start negotiations toward an international legally binding instrument on plastic pollution. This report delves into the pre-session submissions by states and coalitions for the second (INC-2) and third (INC-3) rounds of negotiations, held in 2023. Once the contents of the docume

Historical perspectives on forestry science and monocultures : Ideas of rationality in Sweden during the early twentieth century

This study aims to broaden our historical knowledge about ideas of rationalism and monocultures in forestry science and rational forest management. Empirically, it focuses on the writings of Swedish forestry scientist Henrik Hesselman, active in the early twentieth century. The texts were analyzed using the method of historical contextualization. The study indicates that monocultures historically

Elbussar ur ett stadsplaneringsperspektiv

När man talar om elbussar framhålls ofta deras påverkan på stadsmiljöer, exempelvis vad gäller urbana kvaliteter som luftkvalitet och buller, eller hur etableringen av laddinfrastruktur ska anpassas till både den urbana kontexten och till kollektivtrafikens förutsättningar. Sedan de första elbussarna introducerades i svenska städer för ca 10 år sedan har det funnits förväntningar på att elektrifie

Electrocardiographic proarrhythmic changes in pregnancy of women with CHD

Objectives:Pregnancy-related physiological adaptations result in increased heart rate as well as electrocardiographic changes such as a mean QTc prolongation of 27 ms. Pregnant women with CHD are at increased risk for cardiovascular complications. The aim of this study was to identify risk factors for abnormally prolonged QTc interval—a risk factor for ventricular arrhythmias—in pregnant women wit

Impact of Surgery for Primary Hyperparathyroidism

Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska

Assessment of irrigation and groundwater management strategies in cold arid areas with shallow groundwater tables using a coupled year-round agro-hydrological model

Quantitatively assessing the impact of irrigation and groundwater management strategies is crucial for improving water productivity and soil salinity control in cold arid areas with shallow groundwater tables (CAASGT). However, existing studies often focus on specific periods, either the crop growth period or the freeze–thaw period, due to the lack of appropriate models that can accurately represe

Automated covariate modeling using efficient simulation of pharmacokinetics

Pharmacometric modeling plays an important role in drug development and personalized medicine. Pharmacometric covariate models can be used to describe the relationships between patient characteristics (such as age and weight) and pharmacokinetic (PK) parameters. Traditionally, the functional structure of these relationships are obtained manually. This is a time-consuming task, and consequently lim

Nanosensors for animal infectious disease detection

Infectious diseases in farm animals triggered by pathogenic microorganisms affect the health and well-being of livestock and human populations. Pathogen detection is an important step for the successful diagnosis, treatment and control of infectious diseases in animals. Pathogens that persist in the poultry and livestock industries can be responsible for more than 70% of emerging infections. Thus,

Needs of amyloidosis patients and their care providers : design & first results of the AMY-NEEDS research and care program

Background: Amyloidosis represents a rare yet heterogeneous multi-system disorder associated with a grave prognosis and an enormous psycho-emotional strain on patients, relatives, and caregivers. We here present the overall study design and first results of AMY-NEEDS, a research program aiming to systematically assess the needs of patients suffering from amyloidosis, their relatives and health car

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YOU ARE A DAY TOMORROW – THE CLASSROOM AS BATTLEFIELDYou Are a Day Tomorrow, a spatial audio play, experienced in a classroom. It is a memoir tying past and present, a personal narrative exploring the social dynamics of school and the institutional influence on the body and soul. It presents an auditory sensitivity analysis that examines nostalgia and brutality. You Are a Day Tomorrow is an invita

Anastomotic Leakage in Relation to Type of Mesorectal Excision and Defunctioning Stoma Use in Anterior Resection for Rectal Cancer

BACKGROUND: Anastomotic leakage after anterior resection for rectal cancer is more common after total mesorectal excision compared to partial mesorectal excision but might be mitigated by a defunctioning stoma. OBJECTIVE: The aim is to assess how anastomotic leakage is affected by type of mesorectal excision and defunctioning stoma use. DESIGN: This is a retrospective multicenter cohort study eval

Human behaviour in fire : Knowledge foundation and temporal evolution

Understanding human behaviour in fires (HBiF), whether in building or wildland fire contexts, is crucial for saving lives and managing evacuations. However, existing research lacks a comprehensive analysis of HBiF knowledge from both perspectives. To address this issue, we examined nearly 1900 HBiF-related research papers and their references, identifying around 6600 frequently cited references as