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BackgroundDuring pregnancy and delivery, hemodynamics are altered and complex congenital heart disease has been associated with adverse maternal and neonatal outcomes. We sought to investigate pregnancy outcome and complications in relation to complexity of heart condition.Materials and methodsWe studied women with ACHD discussed at multidisciplinary conferences at Lund University Hospital March 2
It is well known that the intensive biogeochemical activity in hyporheic zone of groundwater and antibiotic contaminated river water induced the pollution diffusion and variation of biogeochemical transformation. However, the complex interaction process caused by water level fluctuation is difficult to accurately depict on a larger, catchment scale. Therefore, a loosely coupled HYDRUS-3D/GMS was e
Process-based land surface models are important tools for estimating global wetland methane (CH4) emissions and projecting their behavior across space and time. So far there are no performance assessments of model responses to drivers at multiple time scales. In this study, we apply wavelet analysis to identify the dominant time scales contributing to model uncertainty in the frequency domain. We
Terrestrial ecosystems are the largest sink for carbon, and their ecosystem gross primary productivity (GPP) regulates variations in atmospheric carbon dioxide (CO2) concentrations. Current process-based ecosystem models used for estimating GPP are subject to large uncertainties due to poorly constrained parameter values. In this study, we implemented a global sensitivity analysis (GSA) on paramet
OBJECTIVE: The Acromegaly Consensus Group reconvened in November 2007 to update guidelines for acromegaly management.PARTICIPANTS: The meeting participants comprised 68 pituitary specialists, including neurosurgeons and endocrinologists with extensive experience treating patients with acromegaly. EVIDENCE/CONSENSUS PROCESS: Goals of treatment and the appropriate imaging and biochemical and clinica
BACKGROUND: GH therapy in adult patients with GH deficiency (GHD) was approved over 10 yr ago, and the indication has subsequently gained broad acceptance. The HypoCCS surveillance database is a suitable means to examine the evolution of diagnostic patterns since 1996.METHODS: Baseline demographics, reported cause of GHD, and diagnostic tests were available from 5893 GH-treated patients. Trends fo
Artificial intelligence (AI) is emerging as an impactful feature of the life, planning and governance of 21st-century cities. Once confined to the realm of science fiction and small-scale technological experiments, AI is now all around us, in the shape of urban artificial intelligences including autonomous cars, robots, city brains and urban software agents. The aim of this article is to criticall
In this study of the effects of lead on the endocrine system, 77 secondary lead-smelter workers (i.e., 62 active and 15 retired) were compared with 26 referents. Lead concentrations were determined in plasma with inductively coupled plasma mass spectrometry (i.e., index of recent exposure), in blood with atomic absorption spectrophotometry, and in fingerbone with K x-ray fluorescence technique (i.
This article presents models to predict the time until mechanical failure of in-ground wooden test specimens resulting from fungal decay. Historical records of decay ratings were modelled by remotely sensed data from ERA5-Land. In total, 2,570 test specimens of 16 different wood species were exposed at 21 different test sites, representing three continents and climatic conditions from sub-polar to
BackgroundAchromobacter xylosoxidans is an emerging pathogen that causes airway infections in patients with cystic fibrosis. Knowledge of virulence factors and protein secretion systems in this bacterium is limited. Twin arginine translocation (Tat) is a protein secretion system that transports folded proteins across the inner cell membranes of gram-negative bacteria. Tat has been shown to be impo
This dissertation is set in the context of the modern space age, which is characterised by an overall increase in space activities on a global scale and a relative increase in private and commercial space activities. Space has become a business case.This study analyses the principle of international responsibility for activities in outer space as mainly codified in Article VI of the Outer Space TrThis dissertation is set in the context of the modern space age, which is characterised by an overall increase in space activities on a global scale and a relative increase in private and commercial space activities. Space has become a business case.This study analyses the principle of international responsibility for activities in outer space as mainly codified in Article VI of the Outer Space Tr
By harnessing the powers of polycrystalline materials an unprecedented, technologically-driven age has taken formover the last 100 years. The polycrystal is today, arguably, the most central building block for electronics, renewableenergy, transportation and medical equipment industries. This material class is the reason for the emergence of thepowerful microprocessors, semiconductors, memory chip
BackgroundOver the last decades, many strategies to procure and improve xylose consumption in Saccharomyces cerevisiae have been reported. This includes the introduction of efficient xylose-assimilating enzymes, the improvement of xylose transport, or the alteration of the sugar signaling response. However, different strain backgrounds are often used, making it difficult to determine if the findin
The inadequacy of public financing mechanisms for sustainable development andclimate action is increasingly evident. The focus has shifted towards private sector financing mechanisms to bridge these financing gaps. This study analyses the Green, Social, Sustainability and Sustainability-linked (GSSS) bonds, considered as the quintessential private sector financing instruments and projected to lead
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un
