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Great social challenges of today no longer come one by one. What makes them great is their ever-greater entanglement in one other and across multiple levels, including landscapes, regimes and niches. To this background, a major challenge facing many countries today is how to successfully address issues of interlocking problems of unsustainability caused by cultural contingents. We argue that while

Background: The form of parental support during pregnancy is constantly changing due to developments in society. ‘Psycho-prophylaxis training’ is a form of parental support used in preparation for childbirth. Only a few studies describe the childbirth experience of both the parents. The aim was to interview parents receiving ‘psycho-prophylaxis training’ during pregnancy and to elucidate their exp

This article concerns the societal history of potato knowledge in early modern Sweden. Focusing on the communication process, it analyses when, how, why, and which type of knowledge of the potato was communicated and ultimately experienced a societal breakthrough in early modern Sweden. The article shows that knowledge of the potato was transformed as it crossed social, spatial, and media boundari

According to Zagaria et al. (2020), evolutionary psychology may be the meta-theory that is needed if psychological science is to enter a paradigmatic stage. Other writers have suggested that what is needed is a person-oriented approach, which focuses on the person as a complex system that needs to be studied (1) as a whole (holism), (2) as an intentional agent in interaction with its environment (

Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for cardiovascular disease. Lp(a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipoprotein (LDL). Many of apo(a)'s potential pathological properties, such as inhibition of plasmin generation, have been attributed to its main structural domains, the kringl

Human carbonic anhydrase IX (CA IX) expression is upregulated in hypoxic solid tumours, promoting cell survival and metastasis. This observation has made CA IX a target for the development of CA isoform-selective inhibitors. To enable structural studies of CA IX-inhibitor complexes using X-ray and neutron crystallography, a CA IX surface variant (CA IXSV; the catalytic domain with six surface amin

A high quality benchmark for small variants encompassing 88 to 90% of the reference genome has been developed for seven Genome in a Bottle (GIAB) reference samples. However a reliable benchmark for large indels and structural variants (SVs) is more challenging. In this study, we manually curated 1235 SVs, which can ultimately be used to evaluate SV callers or train machine learning models. We deve

Risto Hilpinen’s name is associated with seminal contributions to many areas of analytic philosophy, including influential work on deontic logic and the theory of artifacts, as well as important early investigations into inductive logic and indefeasibility analyses of knowledge. A somewhat lesser known body of Hilpinen’s work concerns the theory of inquiry, whereby the central questions are how to

The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS

The identification of important components with the potential for the most disruption is vital in network planning and analysis. Critical infrastructure systems are vulnerable to a variety of failures, whether natural (e.g., space weather, earthquakes) or intentional (e.g., malevolent acts). These systems are increasingly interconnected, which increases the risk of the propagation of disruptions.