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OBJECTIVES: Our objective was to characterize longitudinal patterns of viraemia and factors associated with viral suppression in people with HIV and low-level viraemia (LLV) during antiretroviral therapy (ART).METHODS: We included people with HIV in the EuResist Integrated Database with LLV following ART initiation after 2005. LLV was defined as two or more consecutive viral load (VL) measurements

The aTfaRel2/faRel2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin-antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone synthetase (toxSAS) that inhibits translation through the pyrophosphorylation of uncharged tRNAs at the 3'-CCA end. The toxin is neutralized by the antitoxin ATfaRel2 through the formation of an inactive TA complex. Here, the production, biophys

Föreliggande rapport syftar till att översiktligt rapportera resultaten från forskningsprojektet CYNKA: Kombinerad mobilitet mellan cykel och kollektivtrafik för regional Arbetspendling. Rapporten sammanfattar de olika delar som utgjort projektet som pågått under perioden 2019–2022.Tidigt i projektet genomfördes en litteraturstudie (K2 Working Paper 2021:15). Den visade bland annat att en välfunge

"The Sixties." The powerful images conveyed by those two words have become an enduring part of American cultural and political history. But where did Sixties radicalism come from? Who planted the intellectual seeds that brought it into being? These questions are answered with striking clarity in Andrew Jamison and Ron Eyerman's book. The result is a combination of history and biography that vividl

Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in patients whose disease progresses on covalent BTK inhibitors (BTKis) is a mutation in the BTK 481 cysteine residue to which the inhibitors bind covalently. Pirtob

The characterisation of fast phenomena at the microscopic scale is required for the understanding of catastrophic responses of materials to loads and shocks, the processing of materials by optical or mechanical means, the processes involved in many key technologies such as additive manufacturing and microfluidics, and the mixing of fuels in combustion. Such processes are usually stochastic in natu

The behavioural variant of Alzheimer’s disease (bvAD) is characterized by early predominant behavioural changes, mimicking the behavioural variant of frontotemporal dementia (bvFTD), which is characterized by social cognition deficits and altered biometric responses to socioemotional cues. These functions remain understudied in bvAD. We investigated multiple social cognition components (i.e. emoti

This paper examines how the social ontology that underpins the international human rights framework is being challenged by the affordances of AI/ML systems. To set the stage, the paper adopts a socially situated understanding of human rights – acknowledging the socially embedded nature of individuals within societies. Drawing upon Gould’s theory on the social ontology of human rights, the individu

Background: The aim of this study was to evaluate the effect of surgical specialization and surgeon resection volume on short-term outcome after emergent colon cancer resections. Methods: A retrospective analysis of all patients who underwent resections for colon cancer between 2011 and 2020 at Helsingborg Hospital, Sweden was performed. The senior surgeon participating in each procedure was class

Longitudinal motion of the carotid arterial wall, as measured with ultrasound, has shown promise as an indicator of vascular health. The underlying mechanisms are however not fully understood. We have found, in in vivo studies, that blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Further, we have identified that a tapered geometry and the intramura

The equilibrium organization of two polymers in strong confinement has been extensively investigated in the scope of simple models in the recent past, after it was suggested that the entropic repulsion between polymers could be a mechanism for chromosome separation in living cells. Despite many efforts, how solvent quality can manipulate separation or compaction for the formation of domains in a t

The nature of tourism consumption is a major challenge for rural areas. Rural tourism is uneven in time and space and destinations are simultaneously prone to under- and over-tourism. Rural tourism is often framed as an opportunity to develop tourism in a more sustainable manner. The irony is that rural tourism is still primarily about growth and considerations of the broader context of developmen

Recent studies suggest that firms can reduce their impact on the natural environment through the creative deployment of technologies that create, use, transmit, or source electronic data. While this work on digital sustainability is promising, so far it remained unclear how firms can leverage digital technologies as part of their sustainability management. We address this issue by providing an int

Many studies use traditional alkaline leach digestions to quantify biogenic silica (bSiO2) in sediments. Studies from river-plume systems demonstrate this methodology precludes information on other operational Si reactive pools, missing potentially valuable information on early diagenetic products. We build on previous studies by broadly examining the reactive Si pools in Mississippi River plume-i