Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratif

Strong, cold winds constitute a problem in southern Scandinavia with its open, flat terrain. In the city of Malmö in the south of Sweden there are several new ongoing and planned large development projects, many of which are being constructed in wind exposed areas. One of the planned areas is Nyhamnen, a former harbour area in the north of the city. This paper describes an analysis of a preliminar

This study uses the sanctions imposed on and by Russia in 2014 as an exogenous shock on Swedish firms. The results suggest that the total short‐run cost of these sanctions on the Swedish economy amounted to around 1 billion SEK in 2013 prices, which implies a rather limited impact (around 0.025% of the Swedish GDP). The sanction effects were, however, highly asymmetric, and the direct effect on fi

The Silurian was a time of major climatic transition punctuated by multiple biotic crises and global carbon cycle perturbations. The most severe of these biotic events was the late Silurian (Ludfordian) Lau/Kozlowskii extinction event (LKE) and the associated Lau carbon isotope excursion (CIE). Although the extinction event and Lau CIE are globally documented, the only records thus far of local an

Assessing status of natural resources and ecosystem components is pivotal for management, where indicators or indices often are used as proxies of ecological state. Many indicators, however, lack reference points and are associated with sampling errors and environmental noise, limiting their usefulness in management. Here we present a method for assessing state changes in ecological indicator from

Renewable energies can play an important role to provide electricity to rural communities. This work-study the optimum design of a hybrid hydro-wind, micro-power system in rural area. Six case studies, including the impact of hydro head, flow rate, efficiency, and head loss for micro hydropower with wind turbine hub height were implemented based on HOMER software. The simulation results show the i

The eutrophication problems in lakes on the Yangtze Plain of China have attracted global concern. However, a comprehensive assessment of the eutrophication status and its evolution is still lacking for these regional lakes, mostly because of technical difficulties and/or insufficient data to cover the large region. Our study attempts to fill this knowledge gap by using the entire archive of remote

A major challenge in the design of electrochemical biodevices is to achieve fast rates of electron exchange between proteins and electrodes. In this work, we show that a significant increase in the direct electron transfer rate between a graphite electrode and Tobacco Peroxidase takes place when a surface exposed leucine, located in the vicinity of the heme pocket, is replaced by tryptophan. The a

In this work an experimental and kinetic modeling study on n-propanol and i-propanol combustion has been performed. New burning velocity measurements were carried out using the heat flux method at 1 atm over the temperature range of 323–393 K. Analysis of the temperature dependence was conducted with to verify the data consistency of the new and available data from the literature. Important incons

This paper presents a numerical model designed to simulate subaqueous cross-shore profile behavior, including response of feeder mounds and barred systems. The present model development builds on the semi-empirical model proposed by Larson et al. (2013), designed to simulate the evolution of longshore bars exposed to incident waves, as well as the exchange of material between the bar and the berm

Roads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the boRoads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the bo

In order to overcome the shortcomings of crash data a number of surrogate measures of safety have been developed and proposed by various researchers. One of the most widely used temporal indicators is time-to-collision (TTC) which requires the road users to be on a collision course. Road users that are strictly speaking not on a collision course actually might behave and take evasive actions as if

A substantial portion of grassland photosynthates is allocated belowground to arbuscular mycorrhizal fungi (AMF), but controversy remains about whether this carbon (C) contributes to soil organic carbon (SOC) under warming. The goal of this study was to investigate how AMF biomass and C sequestered by AMF (CNew) are influenced by soil warming. We estimated the AMF biomass and CNew, assumed to be m

Atopic dermatitis (AD) is a complex disease with elevated risk of respiratory comorbidities.1,2 Severely affected patients are often treated with immune-modulating systemic drugs.3,4 On March 11th 2020, the World Health Organization declared the 2019 novel coronavirus severe acute respiratory syndrome (SARS-Cov-2) epidemic to be a pandemic. The number of cases worldwide is increasing exponentially

Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions to map expert opinion on the clinical management of moderate-to-severe atopic de

This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12–14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement