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FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. The macrolide FK506 is a transition-state analog of the catalyzed reaction and displaces FKBP12 from its natural target proteins. We compared the conformational exchange dynamics of the backbone and methyl-bearing side chains of FKBP12 in the free and FK506-bound states using N

Context. The formation and evolution of the Milky Way bulge is still largely an unanswered question. Some of the most essential observations needed for its modelling are the metallicity distribution and the trends of the alpha elements, as measured in stars. While bulge regions beyond R greater than or similar to 50 pc of the centre have been targeted in several surveys, the central part has escap

Background: Surgery under cardiopulmonary bypass (CPB) is still associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully understood. Abnormalities in coronary flow and function have been suggested to play an important role. Prior studies suggest protective effects on coronary and myocardial function by short intravenous (i.v.) infus

Background Smokers have a substantially increased risk of postoperative complications. Preoperative smoking intervention may be effective in decreasing this incidence, and surgery may constitute a unique opportunity for smoking cessation interventions. Objectives The objectives of this review are to assess the effect of preoperative smoking intervention on smoking cessation at the time of surgery

Prolonged periods of allopatry might result in loss of the ability to discriminate against other formerly sympatric species, and can lead to heterospecific matings and hybridization upon secondary contact. Loss of premating isolation during prolonged allopatry can operate in the opposite direction of reinforcement, but has until now been little explored. We investigated how premating isolation bet

Natural resource management requires approaches to understand and handle sources of uncertainty in future responses of complex systems to human activities. Here we present one such approach, the "biological ensemble modeling approach,'' using the Eastern Baltic cod (Gadus morhua callarias) as an example. The core of the approach is to expose an ensemble of models with different ecological assumpti

The study presents the characterization of dynamic patterns of indoor particulate matter (PM) during various pollution episodes for real-time IAQ management. The variation of PM concentrations was assessed for 20 indoor activities, including cooking related sources, other thermal sources, personal care and household products. The pollution episodes were modelled in full-scale test chamber represen

Seven aliphatic dicarboxylic acids (C3-C9) along with phthalic acid, pinic acid and pinonic acid were determined in 35 aerosol (PM10) samples collected over the year at Vavihill sampling station in south of Sweden. Mixture of dichloromethane and methanol (ratio 1:3) was preferred over water for extraction of samples and extraction was assisted by ultrasonic agitation. Analytes were derivatized usi

For the vast majority of computer systems correct operation is defined as producing the correct result within a time constraint (deadline). We refer to such computer systems as real-time systems (RTSs). RTSs manufactured in recent semiconductor technologies are increasingly susceptible to soft errors, which enforces the use of fault tolerance to detect and recover from eventual errors. However, fa

”Sinnlighetens närvaro – Luther mellan kroppskult och kropps- förakt” visar en annan Luther än den vi möter i media. I stället för en Luther som gör att vi arbetar för mycket visar boken en Martin Luther som bejakade sensualism och sinnlighet. Mat, vin, musik och goda vänner var ett sätt att hålla depression och tvivel borta. Kroppen var inte ett hot mot det andliga. Sexualiteten sågs som naturlig

Based on the non-dimensional approach, this study focuses on developing a model to compute design flood for specific return periods whose parameter estimations are done using the Marquardt algorithm considering peak flood data of 100 Indian catchments. The selected flood data varies for majority of the sites for a period of 10 years, and for a few sites up to 36 years; and as a preliminary process

Magnetic properties of MnAs nanocrystals embedded in GaAs are analyzed in the frame of phenomenological model proposed by Sasaki for ferritin superparamagnets. Our calculations explain qualitatively experimental data of magnetization versus temperature; obtained according to zero-field-cooled and field-cooled protocols. They show dynamics of magnetization of MnAs nanocrystals in range of temperatu

In recent years, the antibody microarray technology has made significant progress, going from proof-of-concept designs to established high-performing technology platforms capable of targeting non-fractionated complex proteomes. In these cross-disciplinary efforts, a particular focus has lately been placed on two key technological issues: the sample and data handling. To this end, robust protocols

This investigation concerned the question of whether honeybees collect bacteria that are beneficial for humans from the flowers that contribute to formation of their honey. Bacteria originating from the types of flowers involved, and found in different anatomic parts of the bees, in larvae, and in honey of different types, were sampled during a 2-year period. 16S rRNA sequencing of isolates and cl

PtdIns-4,5-bisphosphate is a lipid messenger of eukaryotic cells playing critical roles in processes such as cytoskeleton organization, intracellular vesicular trafficking, secretion, cell motility, regulation of ion channels and nuclear signalling pathways. The enzymes responsible for the synthesis of PtdIns(4,5)P(2) are phosphatidylinositol phosphate kinases (PIPKs). The moss Physcomitrella pate

This article investigates and discusses a football chant, a riff from a popular rock song entitled “Seven Nation Army” by the rock group The White Stripes from Detroit, USA. The chant is sung by supporters at football matches even in Sweden but also in corresponding social contexts, as when high school students graduate or at the pub. The survey, which was to by a reduction method compare the riff

Mutations in the gene encoding laminin α2 chain, an extracellular matrix protein mainly expressed in the neuromuscular system, cause a severe form of muscular dystrophy, congenital muscular dystrophy type 1A (MDC1A). Laminin α2 chain is associated to the muscle fibers by two major receptors, where one of them, integrin α7β1, is diminished upon laminin α2 chain deficiency. The majority of the skele

The research project “Exclusive Metalworking in Rural Settings” was instigated in 2013 with funding from the Berit Wallenberg Foundation. The objective of the project is to survey sites with remains of multimetal craftsmanship of the late Iron Age and medieval periods outside urban contexts. This article aims to contextualize preliminary results from the project and evaluate its chosen source mate

The authors investigate how Third Mission activities at universities, such as the outreach and technology transfer functions, are anchored in organizational structures and practices, and discuss the implications of this relationship for the success of the activities. They draw on case studies of two Swedish university colleges to illustrate the diversity of mechanisms used to achieve Third Mission