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Smoking and Alcohol Intake but Not Muscle Strength in Young Men Increase Fracture Risk at Middle Age: A Cohort Study Linked to the Swedish National Patient Registry

Published 10 January 2020 We aimed to determine the relationship between handgrip strength, smoking, and alcohol consumption in young men and fracture risk at middle age. Thus, we carried out a cohort study including young men undergoing conscription examination in Sweden from September 1969 to May 1970 at a typical age of 18 years. Data on muscle strength, height, weight, and lifestyle factors we

https://www.lupop.lu.se/article/smoking-and-alcohol-intake-not-muscle-strength-young-men-increase-fracture-risk-middle-age-cohort - 2025-01-08

The Upper Gastrointestinal Cancer Registry (UGICR): a clinical quality registry to monitor and improve care in upper gastrointestinal cancers

Published 11 January 2020 It supports four cancer modules: pancreatic, oesophagogastric, biliary and primary liver cancer. The pancreatic cancer (PC) module was the first module to be implemented, with others being established in a staged approach. Individuals are recruited to the registry if they are aged 18 years or older, have received care for their cancer at a participating public/private hos

https://www.lupop.lu.se/article/upper-gastrointestinal-cancer-registry-ugicr-clinical-quality-registry-monitor-and-improve-care - 2025-01-08

The ratio of total cholesterol to high density lipoprotein cholesterol and myocardial infarction in Women’s health in the Lund area (WHILA): a 17-year follow-up cohort study

Published 11 January 2020 Identifying variables predictive of acute myocardial infarction (AMI) in women is important. The use of the ratio of total cholesterol-to-high density lipoprotein cholesterol (TC/HDL-C) is often overlooked. The aim was to study TC/HDL-C in relation to later AMI, in a large sample of women, adjusted for age, educational status, smoking, waist-hip ratio, blood pressure, and

https://www.lupop.lu.se/article/ratio-total-cholesterol-high-density-lipoprotein-cholesterol-and-myocardial-infarction-womens-health - 2025-01-08

Datainspektionen will recieve more funding and change name

Published 19 December 2017 Datainspektionen (The Swedish Data Protection Authority) will change its name to integritetsskyddsmyndigheten and receive increased funding. The 30 million SEK increase in funding is primarliy aimed towards working with issues regarding personal integrity and the implications of the GDPR for the government sector, private companies and the general public. The agency will

https://www.lupop.lu.se/article/datainspektionen-will-recieve-more-funding-and-change-name - 2025-01-08

Imputing missing data of function and disease activity in rheumatoid arthritis registers: what is the best technique?

Published 12 January 2020 When imputing missing baseline values, all methods underestimated equally the true value, but LME3 and MICE correctly estimated remission and low disease activity rates. When imputing missing follow-up values at 6, 12, or 24 months, NAO provided the least biassed estimate of the mean disease activity and corresponding remission rate. These results were not affected by the

https://www.lupop.lu.se/article/imputing-missing-data-function-and-disease-activity-rheumatoid-arthritis-registers-what-best - 2025-01-08

A new population-based risk stratification tool was developed and validated for predicting mortality, hospital admissions, and health care costs

Published 12 January 2020 The score included 31 conditions selected from a list of 65 candidates whose weights were assigned according to the Cox model coefficients. The model was built from a sample of 5.4 million National Health Service (NHS) beneficiaries from the Italian Lombardy Region and applied to the remaining 2.7 million NHS beneficiaries. Predictive performance was assessed by discrimin

https://www.lupop.lu.se/article/new-population-based-risk-stratification-tool-was-developed-and-validated-predicting-mortality - 2025-01-08

Bias control in the analysis of case–control studies with incidence density sampling

Published 13 January 2020 Previous simulation studies of the case–control study design using incidence density sampling, which required individual matching for time, showed biased estimates of association from conditional logistic regression (CLR) analysis; however, the reason for this is unknown. Separately, in the analysis of case–control studies using the exclusive sampling design, it has been

https://www.lupop.lu.se/article/bias-control-analysis-case-control-studies-incidence-density-sampling - 2025-01-08

Validation study of randomly selected cases of PTSD diagnoses identified in a Swedish regional database compared with medical records: is the validity sufficient for epidemiological research?

Published 13 January 2020 In Sweden, the patients’ diagnoses are recorded in administrative registers. The research value of these registers is determined by their diagnostic validity, that is, if the diagnosis recorded meets the relevant diagnostic criteria. The aim of the study was to assess the validity of post-traumatic stress disorder (PTSD)-diagnoses as compared with case notes in medical re

https://www.lupop.lu.se/article/validation-study-randomly-selected-cases-ptsd-diagnoses-identified-swedish-regional-database - 2025-01-08

Over-coverage in population registers leads to bias in demographic estimates.

Published 14 January 2020 Estimating the number of individuals living in a country is an essential task for demographers. This study assesses the potential bias in estimating the size of different migrant populations due to over-coverage in population registers. Over-coverage-individuals registered but not living in a country-is an increasingly pressing phenomenon; however, there is no common unde

https://www.lupop.lu.se/article/over-coverage-population-registers-leads-bias-demographic-estimates - 2025-01-08

A favorable lifestyle lowers the risk of coronary artery disease consistently across strata of non-modifiable risk factors in a population-based cohort

Published 14 January 2020 A healthy lifestyle has been shown to reduce the risk of coronary artery disease (CAD). The extent to which lifestyle influences the risk of CAD for people with pre-existing non-modifiable risk factors is less studied. We therefore examined the associations between a favorable lifestyle and incidence of CAD in population subgroups based on gender, age, educational level,

https://www.lupop.lu.se/article/favorable-lifestyle-lowers-risk-coronary-artery-disease-consistently-across-strata-non-modifiable - 2025-01-08

Correcting for selective participation in cohort studies using auxiliary register data without identification of non-participants.

Published 15 January 2020 Selective participation may hamper the validity of population-based cohort studies. The resulting bias can be alleviated by linking auxiliary register data to both the participants and the non-participants of the study, estimating propensity scores for participation and correcting for participation based on these. However, registry holders may not be allowed to disclose s

https://www.lupop.lu.se/article/correcting-selective-participation-cohort-studies-using-auxiliary-register-data-without - 2025-01-08

First LUPOP drop-in!

Published 10 January 2020 Monday January 13 at 9-12, we will have our very first LUPOP drop-in! Come to the Tornblad Building, have a look at the LUPOP office and ask questions on population studies! For address and directions, visit https://www.lupop.lu.se/tornblad. 

https://www.lupop.lu.se/article/first-lupop-drop - 2025-01-08

Fortes' open call for proposals is now open

Published 19 December 2017 It is now open to proposals within the research areas health, working life and welfare. There are three kinds of grants to apply for: Project grants, junior research grants and postdoc grants. The deadline is the 1st of February. For more information about this, and the call for proposals regarding research on how to prevent sick leave and promote the return to work, see

https://www.lupop.lu.se/article/fortes-open-call-proposals-now-open - 2025-01-08

Accumulated neighbourhood deprivation and coronary heart disease: a nationwide cohort study from Sweden

Published 16 January 2020 The effect of neighbourhood deprivation on CHD might depend on age. Accounting for individuals’ baseline age may therefore be important for understanding neighbourhood environmental effects on the development of CHD over time. However, because of high correlation of neighbourhood deprivation over time, single-point-in-time assessments may be adequate for CHD risk predicti

https://www.lupop.lu.se/article/accumulated-neighbourhood-deprivation-and-coronary-heart-disease-nationwide-cohort-study-sweden - 2025-01-08

Importance of potentially inappropriate medications, number of chronic conditions and medications for the risk of hospitalisation in elderly in Sweden: a case–control study

Published 16 January 2020 The number of chronic conditions and medications are important for the odds of hospitalisation, while the use of PIM, according to the definition used in this study, was no significant in the full model. New publication in BMJ Journals

https://www.lupop.lu.se/article/importance-potentially-inappropriate-medications-number-chronic-conditions-and-medications-risk - 2025-01-08

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors

Published 17 January 2020 Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201-variant polygenic risk score (PRS) for CAD and tested for interaction with diab

https://www.lupop.lu.se/article/interaction-between-type-2-diabetes-prevention-strategies-and-genetic-determinants-coronary-artery - 2025-01-08

The rate and perioperative mortality of caesarean section in Sierra Leone

Published 17 January 2020 The caesarean section rate has increased rapidly in Sierra Leone, but the distribution remains uneven. Caesarean section mortality is high, but there is wide variation. More access to caesarean sections for maternal and neonatal complications is needed in underserved areas, and expansion should be coupled with efforts to limit late presentation, to offer assisted vaginal

https://www.lupop.lu.se/article/rate-and-perioperative-mortality-caesarean-section-sierra-leone - 2025-01-08

Prevalence of Survival Without Major Comorbidities Among Adults Born Prematurely

Published 18 January 2020 Survival without major comorbidities among persons born extremely preterm (22-27 weeks), very preterm (28-33 weeks), late preterm (34-36 weeks), or early term (37-38 weeks), compared with full-term (39-41 weeks). Comorbidities were defined using the Adolescent and Young Adult Health Outcomes and Patient Experience (AYA HOPE) Comorbidity Index, which includes conditions th

https://www.lupop.lu.se/article/prevalence-survival-without-major-comorbidities-among-adults-born-prematurely - 2025-01-08