Role of the incretin hormone GIP in the development of diabetic vascular complications - good or bad? The incretin hormones GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) are released from the intestine after food ingestion to stimulate insulin secretion in a glucose-dependent manner. Both GIP and GLP-1 are rapidly degraded by the enzyme dipeptidyl peptidase

https://www.ludc.lu.se/research/diabetic-complications/research-areas/role-incretin-hormone-gip - 2025-04-19

Work package 4 of SUMMIT - "Novel animal models of diabetes" Novel means to prevent diabetic complications are needed. An important mean in this undertaking would be to develop tools which would make development of novel drugs for prevention of complications more feasible. The SUMMIT consortium brings together European key leaders in the field of diabetes research; scientists with a deep insight i

https://www.ludc.lu.se/research/diabetic-complications/research-areas/work-package-4-summit - 2025-04-19

Transcriptional regulation of miRNA-212 and miRNA-132 and their fine-tuning function of beta cell insulin secretion Type 2 diabetes is characterized by hyperglycemia due to insulin resistance in the target tissue and insufficient insulin secretion from the beta cells. Finding new mechanisms and pathways involved in the regulation of insulin secretion from the pancreatic beta cells is of great impo

https://www.ludc.lu.se/education-training/theses/theses-2016/helena-malm - 2025-04-19

In search of the missing heritability of celiac disease, from genome-wide linkage & associaiton to a candidate gene approach Celiac diseasd ia a gluten dependent enteropathy of the small intestine, associated with the HLA DQ2 and DQ8 haplotypes and tissue transglutaminase autoantibodies (tTGA). About 40% of the population carries these HLA risk haplotypes, but only 1-3% develoops celias disease. A

https://www.ludc.lu.se/education-training/theses/theses-2016/caroline-monten - 2025-04-19

Study of DNA methylation in human pancreatic islets Today type 2 diabetes is a common disease with a worldwide prevalence of 8.3%. The disease is characterised by hyperglycaemia which is a result of insufficient insulin secretion from the beta-cells in the pancreatic islets as well as an insulin resistance seen in the target tissues. Type 2 diabetes is a multifactorial disease with genetic, epigen

https://www.ludc.lu.se/education-training/theses/theses-2016/elin-hall - 2025-04-19

The human pancreatic islet methylome and its role in type 2 diabetes Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the r

https://www.ludc.lu.se/education-training/theses/theses-2016/tasnim-dayeh - 2025-04-19

Novel insights into the role of serotonin in control of beta-cell function Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolic

https://www.ludc.lu.se/education-training/theses/theses-2016/hedvig-bennet - 2025-04-19

Genetic Determinants of obesity in relation to diet, weight gain and mortality Obesity is one of the major health concerns that has reached epidemic proportions globally. It is generally believed to be a result of interactions between genetic and environmental factors. In this thesis we investigated the role of dietary factors in modifying the genetic susceptibility to obesity (papers I to III), s

https://www.ludc.lu.se/education-training/theses/theses-2016/gull-rukh - 2025-04-19

Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. When insulin resistance develops, the pancreatic beta-cells

https://www.ludc.lu.se/education-training/theses/theses-2006/ulrika-krus - 2025-04-19

Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion. We have investigated the role of lipid metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell dysfunctio

https://www.ludc.lu.se/education-training/theses/theses-2006/malin-fex - 2025-04-19

Genetics of diabetic subtypes There are two major types of diabetes mellitus, Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D), however a number of subtypes have been defined and classified. Maternally Inherited Diabetes and Deafness (MIDD) and Maturity Onset Diabetes of the Young (MODY) are monogenic forms, whereas Latent Autoimmune Diabetes in Adults (LADA) is thought to be a polygenic subtype si

https://www.ludc.lu.se/education-training/theses/theses-2006/camilla-cervin - 2025-04-19

Exploring Positional and Functional Candidate Genes for Type 2 Diabetes Type 2 diabetes (T2D) is a complex, metabolic disorder characterized by hyperglycaemia because of defects in insulin secretion and sensitivity. The rapid increase in T2D is likely to reflect the influence of both genetic and environmental factors in disease development. However, the genetic aetiology of T2D remains largely unk

https://www.ludc.lu.se/education-training/theses/theses-2007/johan-holmkvist - 2025-04-19

Pathophysiology and treatment of defective insulin secretion Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. This thesis investigates the genetic and cellular basis for impaired insuli

https://www.ludc.lu.se/education-training/theses/theses-2007/anders-rosengren - 2025-04-19

Candidate Genes for Late Diabetic Complications Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin requiring (NIR), insulin requiring for control (IRC) and insu

https://www.ludc.lu.se/education-training/theses/theses-2007/eero-lindholm - 2025-04-19

Heritability of blood pressure monogenes and polygenes High blood pressure (BP) is associated with cardiovascular morbidity and mortality. Both genetic and environmental factors are implicated in BP homeostatsis and hypertension development. The aims of the present theisis were: (a) to test if ambulatory BP (ABP) is better than office BP (OBP) to capture the heritable part of BP and if BP variabil

https://www.ludc.lu.se/education-training/theses/theses-2007/cristiano-fava - 2025-04-19

From the pancreatic beta cell to the endothelium: Pathophysiological aspects of Type 2 diabetes The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell

https://www.ludc.lu.se/education-training/theses/theses-2007/marloes-dekker-nitert - 2025-04-19

Assessment and Treatment of Impaired Insulin-Secretion and Action in Type 2 Diabetes Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic cont

https://www.ludc.lu.se/education-training/theses/theses-2008/mozhgan-dorkhan - 2025-04-19

Adipose Tissue Gene Expression & Candidate Genes for Obesity Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene

https://www.ludc.lu.se/education-training/theses/theses-2008/lovisa-e-johansson - 2025-04-19

Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scans and Candidate Genes to Genome Wide Association Studies Type 2 diabetes (T2D) and metabolic syndrome (MetS) are major health problems associated with cardiovascular disease. Both diseases are influenced by a combination of genetic and environmental factors. The aim of this thesis was to identify genetic risk factors

https://www.ludc.lu.se/education-training/theses/theses-2008/marketa-sjogren - 2025-04-19

Beta-Cell Dysfunction in Huntington´s Disease Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocri

https://www.ludc.lu.se/education-training/theses/theses-2009/karl-bacos - 2025-04-19