Outcome of ischaemic foot ulcers in patients with diabetes, with or without revascularization The aim of the studies presented in this thesis was to study patients with diabetes and severe peripheral arterial disease (PAD) in regard to outcomes of foot ulcers, factors related to outcomes, and occurrences of new ulcerations and amputations following healing of the initial ulcer. Patients with diabe

https://www.ludc.lu.se/education-training/theses/theses-2014/targ-elgzyri - 2025-04-19

Gestational diabetes mellitus, prevalence in southern Sweden and risk factors for subsequent diabetes Background: Gestational diabetes mellitus (GDM) is associated with risks during pregnancy, during delivery, and in later life with a substantial risk of subsequent diabetes. The worldwide prevalence of GDM is increasing, but varies with differences in diagnostic methods and population characterist

https://www.ludc.lu.se/education-training/theses/theses-2015/claes-ignell - 2025-04-19

Effects of Ca2+, microRNAs and rosuvastatin on insulin-secreting ceta cell function Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. The exocy

https://www.ludc.lu.se/education-training/theses/theses-2015/vishal-salunkhe - 2025-04-19

Genetic and Environmental Risk Factors in the Development of Obesity Lifestyle behaviors and genetic variation have clear and distinguishable effects on obesity risk; however, the pattern of disease occurrence within and between populations that differ in their genetic and environmental underpinnings suggests obesity is caused in part by the interaction between adverse lifestyle behaviors and the

https://www.ludc.lu.se/education-training/theses/theses-2015/shafqat-ahmad - 2025-04-19

Metabolomics of weight loss and weight maintenance in obese humans The prevalence of obesity and obesity-related complications are increasing worldwide. Weight loss has shown to improve insulin sensitivity and decrease the risk of developing type 2 diabetes (T2D). Even so, little is known about how metabolites, other than glucoses are affected adter weight loss and weight maintenance treatment. Im

https://www.ludc.lu.se/education-training/theses/theses-2016/nina-geidenstam - 2025-04-19

Causes and consequences of hyperglycemia and glycosuria Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases

https://www.ludc.lu.se/education-training/theses/theses-2016/emilia-ottosson-laakso - 2025-04-19

Genome-wide analysis of the DNA methylation landscapes in human tissues The prevalence of type 2 diabetes and obesity is rapidly increasing worldwide. Both pancreatic islets and adipose tissue play an important role in metabolic processes in humans, and dysfunction in these tissues may contribute to the pathogenesis of type 2 diabetes and obesity. Epigenetics is thought to be one of the processes

https://www.ludc.lu.se/education-training/theses/theses-2016/petr-volkov - 2025-04-19

Mechanisms of defective insulin secretion in type 2 diabetes Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological techniques to explore the genetic and cellula

https://www.ludc.lu.se/education-training/theses/theses-2013/taman-mahdi-hamed - 2025-04-19

Development of protocols for metabolomics in biomedical research using chemometrics Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerf

https://www.ludc.lu.se/education-training/theses/theses-2010/anders-danielsson - 2025-04-19

Folate - associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status Folate is a B-vitamin that may influence cancer development via its role as methyl donor for DNA synthesis and methylation. Plant foods contain many bioactive compounds including folate and fiber. Results from the Malmö Diet and Cancer (MDC) cohort indicate lower breast cancer r

https://www.ludc.lu.se/education-training/theses/theses-2010/ulrika-ericson - 2025-04-19

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/louise-nilsson - 2025-04-19

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/sofia-salo - 2025-04-19

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/annika-lundstig - 2025-04-19

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https://www.ludc.lu.se/research-0/epigenetics-and-diabetes/previous-group-members/anders-h-olsson - 2025-04-19

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https://www.ludc.lu.se/research-0/genomics-diabetes-and-endocrinology/clinical-co-workers - 2025-04-19

Master course in Metabolic diseases BIMM23 (7,5 credits) This course is a master course in the Biomedical programme (Lund University) which focuses on human endocrine and metabolic disorders. The course starts with an introduction to the normal physiology of the endocrine systems and how the organs involved control overall metabolism. The following week, endocrine pathophysiology is studied from d

https://www.ludc.lu.se/education-training/master-course-metabolic-diseases - 2025-04-19

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https://www.ludc.lu.se/research-0/cellular-autoimmunity/previous-co-workers - 2025-04-19

Diabetes Prediction in Skåne The DiPiS study is prospective study that involved screening of all newborn infants in Scania (Skåne) county in southern Sweden for risk factors of Type 1 Diabetes (T1D). The study aims at identifying infants and children in Skåne who are genetically susceptible to T1D (having high risk HLA genes) and to follow these children for 15 years to monitor if they will develo

https://www.ludc.lu.se/research/diabetes-and-celiac-disease/research-projects/dipis - 2025-04-19