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Petersén Å, Hansson O, Emgård M and Brundin P.Cell Transplantation 9: 577-584 (2000)AbstractTransplantation of embryonic ventral mesencephalon is a potential therapy for patients with Parkinson's disease. As only around 5-10% of embryonic dopaminergic neurons survive grafting into the adult striatum, it is considered necessary to use multiple donor embryos. To increase the survival of the grafted

https://www.huntington-research.lu.se/grafting-nigral-tissue-hibernated-tirilazad-mesylate-and-glial-cell-line-derived-neurotrophic-factor - 2025-11-29

Brundin P, Karlsson J, Emgård M, Kaminski Schierle GS, Hansson O, Petersén Å and Castilho RF.Cell Transplantation 9: 179-195 (2000)AbstractNeural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3-20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that events

https://www.huntington-research.lu.se/improving-survival-grafted-dopaminergic-neurons-review-over-current-approaches - 2025-11-29

Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P.Proceedings of the National Academy of Sciences USA 96: 8727-8732 (1999)AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neuro

https://www.huntington-research.lu.se/transgenic-mice-expressing-huntingtons-disease-mutation-are-resistant-quinolinic-acid-induced - 2025-11-29

Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. We found significantly larger volumes of surviving graft tissue and of striatal-like tissue (P-zone) within the graft, when the host striatum had been subjected to an excit

https://www.huntington-research.lu.se/impact-preceding-excitotoxic-lesion-and-treatment-ciliary-neurotrophic-factor-striatal-graft - 2025-11-29

Petersén Å and Brundin P.Experimental Neurology 160: 402-412 (1999)AbstractCiliary neurotrophic factor (CNTF) has a protective effect on the striatum in animal models of Huntington's disease. However, the mechanism through which it exerts its effect is not clear. In this study, we show that there is a concentration-dependent direct protective effect of CNTF against N-methyl-D-aspartate-mediated ex

https://www.huntington-research.lu.se/effect-cntf-and-calcium-ionophore-a23187-induced-death-cultured-embryonic-stratal-neurons - 2025-11-29

Petersén Å, Mani K and Brundin P.Experimental Neurology 157: 1-18 (1999)AbstractWe review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG repeat in a gene coding for a protein, with unknown function, called huntingtin. There is selective death of striatal and cortical neurons. Both in patients and a trans

https://www.huntington-research.lu.se/recent-advances-pathogenesis-huntingtons-disease - 2025-11-29

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2025-11-29

Brundin P, Petersén Å and Hansson O.Journal of Neurosurgery 90: 804-806 (1999)No abstract available; this is a letter to the editor.The letter 

https://www.huntington-research.lu.se/graft-survival - 2025-11-29

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2025-11-29

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2025-11-29

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2025-11-29

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2025-11-29

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg FoundationThrough the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SEK

https://www.huntington-research.lu.se/funding - 2025-11-29

Are you wondering how your research findings can make a difference in society? Do you have questions about innovation, patents or are you thinking about starting a company? Do you have any concerns about working together with companies or other organisations? LU Innovation can provide support and guidance on these issues.   One way to ensure that your research findings are put to good use in socie

https://www.innovation.lu.se/en/our-services - 2025-11-29

Thirst relief — without drinking Over 100 million people are undergoing health care with fluid restrictions. Thirst is one of the three most difficult experiences that patients remember after intensive care. SitiSolv has developed a proprietary medical product to alleviate thirst using dry cold. SitiSolv was founded in 2025 by clinicians Jenny Svensson and Mia Hylén together with David Wensbo Posa

https://www.innovation.lu.se/en/sitisolv - 2025-11-29

13 April 2026 08:00 to 18 April 2026 17:00 | Other Save the date! Sustainability Week will be held for the 10th time on 13-18 April – everyone is welcome! Sustainability Week is an annual event where Lund University and Lund Municipality invite people to a week of activities focusing on sustainability. A wide range of topics are discussed during the week, and everyone is welcome.Organise an eventD

https://www.innovation.lu.se/en/calendar/sustainability-week-2026 - 2025-11-29

Pioneering a new era of forensic evidence in criminal investigations  When we think of genetic evidence in criminal investigations, we typically think of human DNA. However, due to its limited availability, static nature, and susceptibility to degradation, human DNA alone often fails to provide definitive forensic answers that can reliably link suspects, objects, and crime scenes.Microdentify has

https://www.innovation.lu.se/en/microdentify - 2025-11-29

7 December 2025 11:59 to 11:59 | Other Do you have a startup or innovation project within tech and looking to connect with customers or investors? Lund University's innovation office, LU Innovation, and its venture builder, LU Ventures, are heading to TechArena 2026 in Stockholm – and we're bringing research- and student-based innovation projects and startups with us. TechArena is one of Scandinav

https://www.innovation.lu.se/en/calendar/deadline-apply-join-techarena-2026-your-startup-or-innovation-project - 2025-11-29

10 December 2025 17:15 to 19:00 | Other Are you a PhD student or postdoc interested in exploring new opportunities beyond academia? Join After Science Network and learn how your research can lead to real-world impact through innovation and entrepreneurship. LU Innovation, together with Lund's Doctoral Student Union and the Doctoral Guild of the faculty of Engineering, invites you to the first edit

https://www.innovation.lu.se/en/calendar/after-science-network - 2025-11-29

4 December 2025 10:00 to 11:00 | Other Are you innovative and want to develop a project within education, entrepreneurship, literature, medicine, music, technology or training? Sten K Johnson Foundation can provide funding and LU Innovation can help you. The Sten K Johnson Foundation awards scholarships of up to 300,000 SEK. Its annual call for 2026 opens on January 15 and closes on February 12.Li

https://www.innovation.lu.se/en/calendar/info-session-qa-sten-k-johnson-foundation-grants-0 - 2025-11-29