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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of genetic variability. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here, we show that thousands of hominoid-specific L1 integrants are expressed in
In Situ Study of Axial GaSb/GaAs Nanowire Heterostructure Formation
Combining multiple III-V materials into axial nanowire heterostructures has enabled the fabrication of custom nanowire-based devices useful for a wide range of applications. However, our ability to form axial heterostructures between arbitrary combinations of III-V compounds is impeded by a lack of information on the dynamics of the heterojunction formation process, often resulting in suboptimal h
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Satellite-Based Monitoring of a Multi-span Pre-stressed Concrete Bridge Crossing the Po River
Satellite-based Synthetic Aperture Radar Interferometry (InSAR) monitoring is a potential complement to conventional Structural Health Monitoring (SHM) methods, due to its non-invasive nature and high spatial coverage. These characteristics allow for continuous monitoring without disrupting bridge operations and enable the exploration of historical data for trend analysis and proactive maintenance
Identifying Drivers and Mechanisms of Climate-Related Tree Mortality
Eastern New South Wales (NSW), Australia, is a region prone to frequent and intense droughts. An unprecedented episode of high temperatures and low rainfall in 2017–2019 culminating in the 2019-2020 summer triggered massive canopy dieback of eucalypt forests throughout the region. Subsequent high rainfall in 2020 offered a unique and rare opportunity to study the process of vegetation recovery fol
Decoding the RNA regulome governing cellular stress responses and cell fate transitions
RNA modifying enzymes play a pivotal role in reshaping gene expression programs in response to diverse intracellular and extracellular cues, thereby maintaining cellular homeostasis. When dysregulated, these enzymes are increasingly implicated in the onset and progression of various diseases. While traditionally recognised for their catalytic functions, mounting evidence suggests that many RNA mod
Sensor response and radiation damage effects for 3D pixels in the ATLAS IBL Detector
Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While
Neuroinflammation during stroke and Gaucher’s disease : How monocyte-derived macrophages and microglia shape the inflammatory environment of the brain
The human brain is a complex and finely tuned organ, constantly monitored and maintained by its resident immune cells.Among these, microglia are the primary regulators of the brain immune environment under physiological conditions, and monocyte-derived macrophages contribute mainly to pathological states such as ischemic stroke and neuronopathic Gaucher’s disease (GD). These two diseases, although
Lyapunov analyses for first-order methods : Theory, automation, and algorithm design
This thesis, comprising four research papers, contributes to the field of systematic and computer-aided analyses and design of first-order methods. The first two papers focus on developing new methodologies, while the remaining two apply these techniques to refine complexity and convergence results, as well as to design new methods. A central theme of the work is the use of Lyapunov-type analyses,
Border Work as Socio Legal Activist Research
This co-authored article develops Border Work (BW) as a methodological approach which is under explored in socio-legal scholar-activism, through analysing two distinct examples. While both examples depart from feminist methodology, the differences are stark: Noor, excluded from democratic processes, faced deportation risks, while we, with institutional support, engaged in public mobilizations withThis co-authored article develops Border Work (BW) as a methodological approach which is under explored in socio-legal scholar-activism, through analysing two distinct examples. While both examples depart from feminist methodology, the differences are stark: Noor, excluded from democratic processes, faced deportation risks, while we, with institutional support, engaged in public mobilizations with
Fission studies using quasi-free NN scattering reactions in inverse kinematics
The combined use of the inverse kinematics technique and the advanced detection setup R3B (Reactions with Relativistic Radioactive Beams) at GSI/FAIR provides unique opportunities to study the fission process. This approach provides access to the complete isotopic identification of the two fission fragments, the precise determination of their velocities and the measurement of the neutrons and gamm
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We measured the angular distributions for the 12C(7Be,3He)16O transfer reaction at 35 MeV leading to several excited states of 16O. The angular distribution of the ground state of 16O was measured for the first time in this reaction. The corresponding Asymptotic Normalization Coefficients (ANC) of all the observed states were determined. The ANC of ground state, 6.92 MeV (2+) and 7.12 MeV (1−) sub
Do Global Inequalities Shape Marriage Market Patterns? : Rethinking Assortative Mating in Cross-National Unions
In recent years, the empirical literature on cross-national unions—marriages between migrants and members of the majority population—has experienced a shift in focus, with an increasing number of studies examining assortative mating patterns within these unions. This shift marks a significant development, indicating that the classic assimilation theory is no longer considered the sole explanation
Charles Tart : A Noetic Pilgrim's Progress
In memoriam of Charles T. Tart
Algorithmic Interaction Ritual Chains on TikTok : Scrolling through Feedback Loops
Algoritmiska rekommendationer har blivit allt mer förekommande i vardagen. Från filmer, musik och potentiella partners till söta katter och roliga danser – sociala medieplattformar utvecklar kraftfulla algoritmer för att förutsäga vad användarna kommer tycka om och behöva. Algoritmiska rekommendationer föreslår dock inte samma innehåll till alla användare, utan anpassar sina rekommendationer dynamAlgorithmic recommendations have become ubiquitous in everyday life. From films, music, and potential partners to cute cats and silly dances, social media platforms develop powerful algorithms to predict what users might like and need. However, algorithmic recommendations do not suggest the same content to all users but instead adapt their recommendations dynamically through endless feedback loops
What do we know about Sotl?
A Review of Defining and Supporting the Scholarship of Teaching and Learning (SoTL): A Sector-Wide Study by Joëlle Fanghanel, Jane Pritchard, Jacqueline Potter, and Gina Wisker
Influence of Al content on thermal stability of nanocrystalline AlxCoCrFeNi high entropy alloys at low and intermediate temperatures
Thermal stability of mechanically alloyed nanocrystalline AlxCoCrFeNi (x = 0, 0.3, 0.6, 1 mol) high entropy alloys (HEAs) has been investigated for the low and intermediate temperature range of 673–1073 K. Single phase FCC structure is observed in the as milled CoCrFeNi. A mixture of FCC and BCC phases is exhibited by × = 0.3, 0.6 and 1, alloys where the volume fraction of BCC increases with incre
Enhancement of microwave absorption properties of epoxy by sol–gel-synthesised ZnO nanoparticles
The microwave absorption property of epoxy resins is generally poor, which can be improved by introducing fillers such as carbon nanotubes and metal oxide nanoparticles (NPs) having good microwave absorption characteristics. In this paper, the microwave absorption properties of epoxy-ZnO nanocomposites have been studied. The ZnO NPs were synthesised using the sol–gel technique and characterised fo
Patterns as basis for immersivity across the arts : A practice-led hypothesis
This article introduces the pattern theory of immersivity (PTI), a practice-led theoretical framework stemming from the hypothesis that a reorientation of the understanding of immersive art is needed, away from technological sophistication or sensory excess and toward the psychological mechanisms underlying imaginative engagement, regardless of artform or combination of media. The theory posits th
