This paper uses newly collected data from a large-scale census (Catastro de la Ensenada) to investigate the scale and causes of market integration in eighteenth century Spain. We use wheat prices observed in more than 5,200 municipalities to analyse the local spatial dependence of prices. We detect several regional clusters in the centre and coasts but find that these were not integrated with each

I detta arbete kommer vi att visa några entydighetssatser för Helmholtz' ekvation. Området begränsas av en yta S som är oändlig. Främst kommer satser som visar entydigheten hos material med förluster att tas fram, men för vissa speciella ytor S kan även rent förlustfria medier behandlas.Randvillkoren kommer att vara av Churchills typ eller mot svarande för permeabla medier. Som ett led i beviskedj

Memory, Intermediality, and Literature investigates how selected literary works use intermedial strategies to represent and perform cultural memory. Drawing on the theoretical perspectives of cultural memory studies, this engaging, reader-friendly monograph examines new materialism and intermediality studies, analyzying works by Alexander Kluge, W.G. Sebald, Jonathan Safran Foer, Anne Carson, Mett

Serine deficiency disorders comprise a new group of inborn errors of serine metabolism. Patients affected with these disorders present with major neurological symptoms including congenital microcephaly, seizures, psychomotor retardation or polyneuropathy. The diagnosis of serine deficiency is based on the detection of low concentrations of the amino acids serine and glycine in fasted plasma and ce

3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency is an inborn error of serine biosynthesis. Patients are affected with congenital microcephaly, psychomotor retardation, and intractable seizures. The effects of oral treatment with amino acids were investigated in 2 siblings. L-Serine up to 500 mg/kg/day was not sufficient for seizure control. Addition of glycine 200 mg/kg/day resulted in comple

Urbane design concerns itself with promoting thequalities associated with the urban – dynamism, transversal networks, etc. – in places where these do not(yet) exist. Urbane design can be considered a neoliberal off-shoot of ‘urban curating’ and other contemporary forms of extending architectural practice intothe social realm. The urbane designer is the creativemanager of the creative city, whose s

Living systems integrate biochemical reactions that determine the functional state of each cell. Reactions are primarily mediated by proteins. In proteomic studies, these have been treated as independent entities, disregarding their higher-level organization into complexes that affects their activity and/or function and is thus of great interest for biological research. Here, we describe the imple

Repair of injured peripheral nerve trunks in the hand and upper extremity still represents one of the most challenging surgical constructive problems. In adults, discriminative sensory functions of the hand do not usually recover despite use of microsurgical repair techniques. A major reason for the imperfect outcome is the pronounced functional cortical reorganizations that occur after nerve inju

Background: As part of I-O Optimise, a multinational research platform providing real-world insights into the management of lung cancers, the SCAN-LEAF study aims to describe the epidemiology, clinical care, and outcomes for pts with NSCLC in Scandinavia. Here, we report temporal OS trends among pts diagnosed with incident NSCLC from 2005 to 2015 in Denmark and Sweden. Methods: The SCAN-LEAF Danis

Climate induced extreme weather events and weather variations will affect both the demand of energy and the resilience of energy supply systems. The specific potential impact of extreme events on energy systems has been difficult to quantify due to the unpredictability of future weather events. Here we develop a stochastic-robust optimization method to consider both low impact variations and extre

The increased survival in malignant cutaneous melanoma (melanoma) is probably due to early diagnosis combined with improved treatment most recently. National health campaigns and screening programs for melanoma detection were started in Sweden several decades ago. We want to assess the influence of tumor characteristics, based on the TNM classification, and of second primary cancers on overall sur

Background: Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. β-blocker treatment is a key quality of care indicator in the Swedish national quality register for acute coronary care, Riks-HIA. Between 2011 and 2015 a declining number of MI-patients discharged with a β-blocker fr