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Biased Estimates of Environmental Impact in the Negative Footprint Illusion : The Nature of Individual Variation

People consistently act in ways that harm the environment, even when believing their actions are environmentally friendly. A case in point is a biased judgment termed the negative footprint illusion, which arises when people believe that the addition of “eco-friendly” items (e.g., environmentally certified houses) to conventional items (e.g., standard houses), reduces the total carbon footprint of

Personality, Positive Psychology and Evaluatively Neutralised Measurements

Examining the relationship between personality and positive psychology can when using a standard measure of personality produce spurious correlations, due to socially desirable responding (aka the evaluative factor). In this study Big Five measures of personality were related to the five most common measures of positive psychology. Using both an evaluative and an evaluatively neutralised measure o

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platele

Band termination spectroscopy in 157Er

The level scheme of 157Er has been extended from a spin region where the nucleus behaves as a prolate rotor to a region where the spin is produced by the alignment of all or most of the available valence nucleons along the symmetry axis of a weakly deformed oblate shape. The level scheme was established at high spin using up to four-fold gamma -ray coincidences detected in the Eurogam spectrometer

Kenneth Grant (Typhonian Order), "Vinum Sabbati" (1961)

This chapter highlights Kenneth Grant’s “Vinum Sabbati” (1961). Grant became an influential figure in the British Thelemic movement, and to some extent British occultism in general, after Aleister Crowley’s death in 1947. “Vinum Sabbati” is a short essay on the Witches’ Sabbath, and two principal lines of reasoning are intertwined in the text. To some extent, Grant argues that the witches’ Sabbath

Prognostic importance of biomarkers associated with haemostatic, vascular and endothelial disturbances in acute coronary syndrome patients in relation to kidney function

BACKGROUND: Patients with kidney failure have a high risk for cardiovascular events. We aimed to evaluate the prognostic importance of selected biomarkers related to haemostasis, endothelial function, and vascular regulation in patients with acute coronary syndrome (ACS), and to study whether this association differed in patients with renal dysfunction.METHODS: Plasma was collected in 1370 ACS pat

An analytical approach for determining snowmelt induced runoff

Different approaches are made to simulate snowmelt induced runoff using physically based equations. It is shown that overland flow as well as subsurface flow to rivulets or gullies may produce large runoff fluctuations when the rain or melt flux to the snowcovered ground is intermittent or periodic. A literature review and theoretical considera- tions show that groundwater often makes the largest

The composition of the gut microbiota shapes the colon mucus barrier

Two C57BL/6 mice colonies maintained in two rooms of the same specific pathogen-free (SPF) facility were found to have different gut microbiota and a mucus phenotype that was specific for each colony. The thickness and growth of the colon mucus were similar in the two colonies. However, one colony had mucus that was impenetrable to bacteria or beads the size of bacteria - which is comparable to wh

BRCA1 frameshift variants leading to extended incorrect protein C termini

Carriers of BRCA1 germline pathogenic variants are at substantially higher risk of developing breast and ovarian cancer than the general population. Accurate identification of at-risk individuals is crucial for risk stratification and the implementation of targeted preventive and therapeutic interventions. Despite significant progress in variant classification efforts, a sizable portion of reporte

BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer’s patches

Gut-derived antigens trigger immunoglobulin A (IgA) immune responses that are initiated by cognate B cells in Peyer’s patches (PPs). These cells colonize the subepithelial domes (SEDs) of the PPs and subsequently infiltrate pre-existing germinal centers (GCs). Here we defined the pre-GC events and the micro-anatomical site at which affinity-based B cell selection occurred in PPs. Using whole-organ

Effect of uncertainty of material parameters on stress triaxiality and Lode angle in finite elasto-plasticity—A variance-based global sensitivity analysis

This work establishes a computational framework for the quantification of the effect of uncertainty of material model parameters on extremal stress triaxiality and Lode angle values in plastically deformed devices, whereby stress triaxiality and Lode angle are accepted as key indicators for damage initiation in metal forming processes. Attention is paid to components, the material response of whic

Mid-Ludfordian uranium isotope records distinguish the role of expansive marine anoxia in global carbon cycle dynamics during the late Silurian Lau/Kozlowskii bioevent

The late Silurian Lau/Kozlowskii bioevent marks a time interval with substantial loss in marine biodiversity linked to the largest positive carbon isotope excursion (Mid-Ludfordian CIE; MLCIE) recorded in the Phanerozoic (δ13Ccarb peaks at +8–10‰). The positive δ13C excursion and the extinctions have been linked to increased marine productivity (ocean eutrophication), leading to increased organic

Highly deformed rotational structures in 136Pm

Four highly deformed structures in the odd-odd nucleus 13661Pm75 were observed via the 105Pd(35Cl,2p2n) reaction at 180 and 173 MeV using the GAMMASPHERE γ-ray spectrometer and the Microball charged-particle detector array. Quadrupole moment measurements were performed on all of the bands. In contrast to lighter odd-Ζ Pm and Pr nuclei, bands based on the g9/2[404]9/2 proton orbital were not observ

Politikerna struntar i klimatforskningen : 420 forskare: Regeringens politik är katastrofal – nu måste fler svenskar kräva en omställning

DEBATE. We researchers have long demanded that the government take climate research seriously and speed up the transition to a sustainable society.Instead, the government is pursuing a policy that deliberately increases emissions. Now more citizens need to raise their voices and show that we demand a knowledge-based climate transition, and it is urgent.

Infrastructural considerations of implementing gene therapy for hemophilia in the Nordic context

Background: Despite improvements in hemophilia care, challenges remain, including treatment burden and impaired quality of life. Gene therapy may overcome these. However, its introduction presents a challenge. Objectives: To outline a function-based gene therapy working model describing critical milestones associated with gene therapy handling, administration, and follow-up to facilitate and imple

Tumor Control Probability and Small-Scale Monte Carlo Dosimetry : Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy

In radiopharmaceutical therapy, intratumoral uptake of radioactivity usually leads to heterogeneous absorbed dose distribution. The likelihood of treatment success can be estimated with the tumor control probability (TCP), which requires accurate dosimetry, estimating the absorbed dose rate per unit activity to individual tumor cells. Methods: Xenograft cryosections of the prostate cancer cell lin

Innovations, informality, and the global south : A thematic analysis of past research and future directions

The informal sector of the global south has lately started to gain attention from innovation and development studies scholars. Studies highlighting the determinants, barriers, social processes, and institutions that influence innovations in the informal sector have enriched the discussion on the topic. This paper analyzes the existing body of knowledge at the intersection of the informal sector, i

A highly-detailed anatomical study of left atrial auricle as revealed by in-vivo computed tomography

The left atrial auricle (LAA) is the main source of intracardiac thrombi, which contribute significantly to the total number of stroke cases. It is also considered a major site of origin for atrial fibrillation in patients undergoing ablation procedures. The LAA is known to have a high degree of morphological variability, with shape and structure identified as important contributors to thrombus fo