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Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine

Neuron generation persists throughout life in the hippocampus but is altered in animal models of neurological and neuropsychiatric diseases, suggesting that disease-associated decline in cognitive and emotional hippocampal-dependent behaviours might be functionally linked with dysregulation of postnatal neurogenesis. Depletion of the adult neural stem/progenitor cell (NSPCs) pool and neurogenic de

Numerical Study and Experimental Verification of Biomass Conversion and Potassium Release in a 140 kW Entrained Flow Gasifier

In this study, a Eulerian-Lagrangian model is used to study biomass gasification and release of potassium species in a 140 kW atmospheric entrained flow gasifier (EFG). Experimental measurements of water concentration and temperature inside the reactor, together with the gas composition at the gasifier outlet, are used to validate the model. For the first time, a detailed K-release model is used t

Prospects for the expansion of standing wave ambient pressure photoemission spectroscopy to reactions at elevated temperatures

Standing wave ambient pressure photoemission spectroscopy (SWAPPS) is a promising method to investigate chemical and potential gradients across solid-vapor and solid-liquid interfaces under close-to-realistic environmental conditions, far away from high vacuum. Until now, these investigations have been performed only near room temperature, but for a wide range of interfacial processes, chief among

Prevalence and comorbidity of psychiatric disorders among treatment-seeking elite athletes and high-performance coaches

Objectives Few studies have evaluated the prevalence of psychiatric disorders among treatment-seeking elite athletes (EA) or high-performance coaches (HPC) in psychiatric outpatient settings. Methods Descriptive overview of EA and HPC with psychiatric disorders at two publicly funded psychiatric outpatient treatment clinics in Stockholm and Malmö, Sweden. Co-occurring psychiatric disorders were il

Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of PDAC.A better understanding of how early human PDAC metabolically communicates with its environment and differs from healthy pancreas could help improve

MRI-only radiotherapy from an economic perspective : Can new techniques in prostate cancer treatment be cost saving?

BACKGROUND AND PURPOSE: The aim of this study was to analyze a magnetic resonance imaging (MRI)-only radiotherapy workflow from an economic perspective in terms of reduced time, costs and systematic uncertainties.MATERIAL/METHODS: A documented Swedish clinical implementation of MRI-only radiotherapy was used as template for cost assessments compared to a combined computed tomography (CT)/MRI workf

A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI : On the influence of head motion at 3T

PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to as

Gait parameters when walking with or without rollator on different surface characteristics : a pilot study among healthy individuals

Objectives: Gait parameters can measure risks of falling and mortality and identify early stages of frailty. The use of walking aid changes gait parameters. The aim of this study was to describe differences in gait parameters among healthy adults when walking on different surfaces and under different conditions, with and without a rollator. Results: Ten healthy participants walked first without an

Healthcare professionals' perceived barriers and facilitators of health behavior support provision : A qualitative study

Background: Childhood cancer survivors (CCSs) have an increased risk of developing chronic health conditions. Evidence suggests that poor health behaviors further increase health risks. Healthcare professionals (HCPs) involved in survivorship care have a key role in providing health behavior support (HBS) but can feel limited in their ability to do so. This study aims to explore European HCPs perc

The European Union’s Self-conception of its Roles in Global Affairs

In many ways, the European Union (EU) may be considered a unique foreign policy actor, combining a peculiar institutional design and set of resources with a specific normative agenda for and ambition in global affairs. Through a two-stage analysis, this chapter examines the role self-conception of the EU as it appears from the EU Global Strategy, released in 2016 as the overarching guide for forei

Är det fel eller är det fel på felbegreppet? Det är det garanterat! Om innebörden av entreprenörens ansvar för fel under garantitiden i AB 04 kap. 5 § 5

I svensk rätt saknas lagstiftning som reglerar kommersiella entreprenadavtal. Istället regleras sådana avtal genom särskilda standardavtal som utarbetats av branschföreträdare under flera decennier. AB 04 är ett av de mest centrala standardavtalen på den kommersiella entreprenadrättens område. Syftet med denna framställning är att utreda innebörden av garantiansvaret i AB 04 kap. 5 § 5. Enligt deThere is no legislation regulating construction contracts between commercial parties in Sweden. Instead, these types of contracts are governed by special standard-form contracts that have been developed by industry representatives over several decades. AB 04 (General conditions of contract for building and civil engineering works and building services) has gained a central position in the field of

Quantitative Proteomics Indicate Radical Removal of Non-Small Cell Lung Cancer and Predict Outcome

Non-small cell lung cancer (NSCLC) is associated with low survival rates, often due to late diagnosis and lack of personalized medicine. Diagnosing and monitoring NSCLC using blood samples has lately gained interest due to its less invasive nature. In the present study, plasma was collected at three timepoints and analyzed using proximity extension assay technology and quantitative real-time polym

Digital resource abundance : How social media shapes success and failure of online mobilisation

This article explores how and why some online protests manage to gain digital resource abundance, that is, mobilising large numbers of people and attracting wide interest and support in a short space of time. The study focuses on the case of the Swedish Petrol Uprising 2.0 which after a few months managed to mobilise 630,000 members on Facebook. The article expands established theories on online m