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The Amazon, located in northern South America, is the world's largest river basin, and covers an area of about 6.5 million km2. The observed interannual variability in precipitation and water availability during its main discharge season has been shown to be influenced by Pacific and Atlantic Ocean sea surface temperatures (SSTs). However, the links between large-scale atmospheric motion and local
The variability of water availability in the Amazon Basin is highly related to the sea surface temperature (SST) pattern over the Atlantic and the Pacific Oceans. The possibility of forecasting this variability one season in advance is a necessity for the correct management of water in the region for water supply, energy production, and flood control. Here we present the development of a statistic
The monthly patterns of northest Brazil (NEB) precipitation are analyzed in relation to sea surface temperature (SST) in the tropical Pacific and Atlantic Oceans, using singular value decomposition. It is found that the relationships between precipitation and SST in both basins vary considerably throughout the rainy season (February-May). In January, equatorial Pacific SST is weakly correlated wit
The overall daily rainfall pattern of Ceará for 19 years, 1974-1992, was analyzed in terms of physiography and atmospheric circulation. This information was used to suggest a regionalization of the state's rainfall into homogeneous areas. The three large-scale precipitation mechanisms (Intertropical Convergence Zone, cold fronts, and upper air vortices) interact and create a certain rainfall patte
Lactic acid bacteria constitute a diverse group of industrially significant, safe microorganisms that are primarily used as starter cultures and probiotics, and are also being developed as production systems in industrial biotechnology for biocatalysis and transformation of renewable feedstocks to commodity- and high-value chemicals, and health products. Development of strains, which was initially
Crop harvesting and residue removal from croplands often result in imbalanced biogeochemical cycles of carbon and nutrients in croplands, putting forward an austere challenge to sustainable agricultural production. As a beneficial element, silicon (Si) has multiple eco-physiological functions, which could help crops to acclimatize their unfavorable habitats. Although many studies have reported tha
Amyloid peptides are the main component of one of the characteristic pathological hallmarks of Alzheimer's disease (AD): senile plaques. According to the amyloid cascade hypothesis, amyloid peptides may play a central role in the sequence of events that leads to neurodegeneration. However, there are other factors, such as oxidative stress, that may be crucial for the development of the disease. In
The nocebo effect is defined as the incitement or the worsening of symptoms induced by any negative attitude from non-pharmacological therapeutic intervention, sham, or active therapies. When a patient anticipates a negative effect associated with an intervention, medication or change in medication, they may then experience either an increase in this effect or experience it de novo. Although less
Poly(propylene imine) (PPI) glycodendrimers are promising candidates as drug carriers and antiamyloidogenic and antiprionic agents. In this study the anti-β-amyloid capacity of PPI glycodendrimers of the fourth and fifth generations was investigated in vitro and in vivo. We assessed distinct PPI glycodendrimers including G4mDS and G5mDS, with electroneutral maltose shell, and G4mOS and G4m-IIIOS,
Dendrimers have been proved to interact with amyloids, although most of dendrimers assayed in amyloidogenic systems are toxic to cells. The development of glycodendrimers, poly(propyleneimine) (PPI) dendrimers decorated with maltose (Mal), represents the possibility of using dendrimers with a low intrinsic toxicity. In the present paper we show that fourth (PPI-G4-Mal) and fifth (PPI-G5-Mal) gener
Granular non-fibrillar aggregates (GNAs) are identified as possible toxic species in Alzheimer's disease. GNAs form on the surface of negatively charged biological membranes and as a consequence of an acidic environment, off the polymerization pathway at neutral pH. Aβ (1-40) GNAs disturb the bilayer structure of model membranes and seem to be more toxic to cells with negatively charged membranes
En kartläggning av stentrycksteknikens första decennium i Sverige.
The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo gro
A search for exotic decays of the Higgs boson into a pair of spin-zero particles, H → aa, where the a-boson decay sin to b-quarks promptly or with a mean proper lifetime cτa up to 6 mm and has a mass in the range of 20–60 GeV, is presented. The search is performed in events where the Higgs boson is produced in association with a W or Z boson, giving rise to a signature of one or two charged lepton
An angular analysis of the decay Bd 0 → K∗μ+μ− is presented, based on proton-proton collision data recorded by the ATLAS experiment at the LHC. The study is using 20.3 fb−1 of integrated luminosity collected during 2012 at centre-of-mass energy of s=8 TeV. Measurements of the K* longitudinal polarisation fraction and a set of angular parameters obtained for this decay are presented. The results ar
Background To benefit from the increasing clinical evidence, organisational changes have been among the main drivers behind the reduction of ICU mortality during the last decade. Increasing demand, costs and complexity, amplifies the need for optimisation of clinical processes and resource utilisation. Thus, multidisciplinary teamwork and critical care processes needs to be adapted to profit from
Microglia are ramified cells that exhibit highly motile processes, which continuously survey the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia have long been recognized as a crucial player in generating and maintaining inflammatory responses in the CNS, now it has become clear, that their function are much more diverse, particularly in the healthy brain. The i
