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The digestive machinery of a human gut bacterium : Structural enzymology of galactomannan utilisation

Vi kryllar av bakterier. De bor framför allt i vår tjocktarm där de lever på de delar av vår mat som vi inte kan ta hand om själva. I utbyte omvandlar bakterierna en del av maten de äter till vitaminer och fettsyror som är viktiga för oss. Det bor flera olika arter av bakterier i vår tarm som äter lite olika saker, eftersom det är ont om mat för så många har de flesta specialiserat sig för att minHuman gut bacteria utilise different types of polysaccharides present in our diet. One of these polysaccharides is galactomannan. Many organisms in the phylum Bacteroidetes have gene clusters encoding for all proteins required for hydrolysis, binding and transport of one type of polysaccharide, called polysaccharide utilisation loci (PULs). A PUL from the human gut bacterium Bacteroides ovatus was

Coppinsiella and Seawardiella – two new genera of the Xanthorioideae (Teloschistaceae, lichen-forming Ascomycota)

The genera Coppinsiella and Seawardiella are described based on the combined phylogenetic analysis from ITS nrDNA, 28S nrLSU and 12S mtSSU sequences. The affinities of the new genera Orientophila, Athallia, Flavoplaca and Calogaya are discussed. The former Caloplaca lobulata group (or ‘Xanthoria lobulata-Gruppe’ sensu Steiner et Poelt 1982) found to be positioned in the Calogaya clade based on ITSThe genera Coppinsiella and Seawardiella are described based on the combined phylogenetic analysis from ITS nrDNA, 28S nrLSU and 12S mtSSU sequences. The affinities of the new genera Orientophila, Athallia, Flavoplaca and Calogaya are discussed. The former Caloplaca lobulata group (or ‘Xanthoria lobulata-Gruppe’ sensu Steiner et Poelt 1982) found to be positioned in the Calogaya clade based on ITS

Income distribution and health in Latin America. The interplay between social determinants of health for explaining health inequities

Even though there is persuasive evidence to support the association between income distribution and health, research in the field is still progressing. There are questions, for instance, about the significance of the association in different countries and about the mechanisms linking income distribution and health. Addressing these issues, this doctoral thesis explores the influence of income dist

Setup for microwave stimulation of a turbulent low-swirl flame

An experimental setup for microwave stimulation of a turbulent flame is presented. A low-swirl flame is being exposed to continuous microwave irradiation inside an aluminum cavity. The cavity is designed with inlets for laser beams and a viewport for optical access. The aluminum cavity is operated as a resonator where the microwave mode pattern is matched to the position of the flame. Two metal me

Socioekonomisk stress tidigt i livet och tillit till andra senare under livscykeln

Generaliserad tillit till andra människor är både en individuell psykologisk egenskap och en kollektiv egenskap hos sociala kontexter/samhällen. Vissa författare betraktar tillit som en aspekt av socialt kapital. Tillit formas genom vänskapliga relationer, ömsesidighet, ömsesidig hjälp, jämlika relationer, samarbete och optimism och jämlikhet och religion under tonåren och vuxenlivet. Speciellt mi

Social capital in epidemiology

Inspired by Putnam’s study of Italy, this chapter develops applications that test the issue of social capital and health in the context of social epidemiology. Three central concepts are explained. The chapter attends to the technical issues, including, for example, the portion of children in subgroups identifying conflicts. The author then comes to his main message: the value of longitudinal expe

Pan-cancer analysis of neoepitopes

Somatic variations are frequent and important drivers in cancers. Amino acid substitutions can yield neoantigens that are detected by the immune system. Neoantigens can lead to immune response and tumor rejection. Although neoantigen load and occurrence have been widely studied, a detailed pan-cancer analysis of the occurrence and characterization of neoepitopes is missing. We investigated the pro

Protein stabilization with retained function of monellin using a split GFP system

Sweet proteins are an unexploited resource in the search for non-carbohydrate sweeteners mainly due to their low stability towards heating. Variants of the sweet protein monellin, with increased stability, were derived by an in vivo screening method based on the thermodynamic linkage between fragment complementation and protein stability. This approach depends on the correlation between mutational

Pickering emulsifiers based on hydrophobically modified small granular starches Part II – Effects of modification on emulsifying capacity

Small granular starches from rice, quinoa, and amaranth were modified with octenyl succinic anhydride (OSA) at 5 defined intervals (0–3.0%) and investigated with respect to emulsifying capacity and stability. Starch granule surfaces were characterized by Brunauer–Emmett–Teller and contact angle measurements. Emulsifying capacity was characterized by multiple light scattering (MLS) and particle siz

Effects of III-V semiconductor nanowires on human lung cells

Due to unique electronic and optical properties, semiconductor nanowires (NW) are widely used in various opto-electronic devices. Concerns have been raised about using NW since they share morphological similarities with nanofibers, such as carbon nanotubes and asbestos. However, the effects of NW exposure on humans remain unknown and there is a pressing need to assess any possible NW toxicity. Dur

Three-year recurrence of Dupuytren’s contracture after needle fasciotomy and collagenase injection : a two-centre randomized controlled trial

Collagenase injection and needle fasciotomy have similar short-term outcomes in the treatment of Dupuytren’s contracture. The purpose of this study was to compare the recurrence rate of these two procedures 3 years after index treatment of primary disease. We enrolled 93 patients (96 rays) from a previous two-centre randomized controlled trial. The rays that had been retreated or showed an increas

Robe de Cour at the Swedish Court

The French court dress Le grand habit, worn at many European courts during the 18th century, was introduced in Sweden in the 1740’s by the crown princess Lovisa Ulrika, sister to Fredric II of Prussia. The robe de cour remained the official ceremonial dress for women at the Swedish court until Gustavus III launched the Swedish National Costume in 1778. The four robes de cour preserved in the Royal