Zinc is required for the regulation of proliferation, metabolism, and cell signaling. It is an intracellular second messenger, and the cellular level of ionic, mobile zinc is strictly controlled by zinc transporters. In mammals, zinc homeostasis is primarily regulated by ZIP and ZnT zinc transporters. The importance of these transporters is underscored by the list of diseases resulting from change

Article 20 of the United Nations Convention on the Rights of the Childrecognises the vulnerability of children growing up outside a familyenvironment, and sets the ground for the paradigm of ‘institutions asa last resort’. However, ‘care homes’ or ‘hostels’ are still common formsof alternative care solutions for children from impoverished familiesin India. This article asks to what extent the clea

The work in this thesis was carried out to highlight important chemical pathways in skeletal mechanisms for the three smallest alcohol fuels (methanol, ethanol and npropanol), two representative fuel alkanes n-heptane and n-decane, and finally the biodiesel surrogates, methyl-decanoate, methyl-5-decenoate, and methyl-9-decenoate. This aim was set up to further the efforts of creating Computational

Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t

The demands on library services are quickly changing in a continually updating digital age. This increases the importance of a good understanding of the needs and demands of the users. In order to sample and follow the change in user needs library organisations analyse their efforts using a series of different methods. In a recent survey distributed to all 301 European LIBER university libraries,

OBJECTIVE: The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells.MATERIALS AND METHODS: Cellular import of LL-37 and synthetic dsRNA (poly I:C) were investigated by immunocytochemistry and fluorescence imaging. Transcript and protein express

The present invention relates to a non-fermented composition having the ability to increase the formation of butyric acid in the colon and comprising at least one cereal based fraction and at least one isolated probiotic strain of Lactobacillus as well as the use of said non-fermented composition as a synbiotic and for treatment of the metabolic syndrome, ulcerative colitis, Crohns disease, Irrita

This open access book seeks to understand how politics is being made in a pluralistic sense, and explores how these political struggles are challenging and transforming gender, sexuality, and colonial norms. As researchers located in Sweden, a nation often cited as one of the most gender-equal and LGBTQ-tolerant nations, the contributions investigate political processes, decolonial struggles, and

This article contends that cultural, political and historical factors create a local political environment where de facto discrimination against women is the norm. Without thoroughly addressing and altering the underlying issues causing discrimination against women in politics, a weak quota system will not immediately lead to increased women's participation in Bali. This paper argues that the lead

The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell