To evaluate the role of polymer-surfactant interactions in drug solubilisation/stabilisation during the dissolution of spray-dried solid dispersions and their potential impact on in vivo drug solubilisation and absorption. Dissolution/precipitation tests were performed on spray-dried HPMC-Etravirine solid dispersions to demonstrate the impact of different surfactants on the in vitro performance of

To chemically modulate the ubiquitin-proteasome system for degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier we discovered such properties of the stem cell-supporting small molecule UM171 and identified that members of the CoREST complex (RCOR1 and LSD1) are targeted for degradation. UM171 supports the in vitro propagation of hematopoieti

Deep learning techniques can use public data such as facial photographs to predict sensitive personal information, but little is known about what information contributes to the predictive success of these techniques. This lack of knowledge limits both the public’s ability to protect against revealing unintended information as well as the scientific utility of deep learning results. We combine conv

I denna studie utforskar jag mitt intresseområde vilket är pianoundervisning inom den klassiska musikgenren på ett mer ingående sätt. Syftet med denna studie var att undersöka hur fem pianolärare, verksamma i fyra olika länder, strukturerar sina pianolektioner. Studiens fokus låg på grundskolor inom musik med klassisk inriktning. Det är en fördjupad studie i vad det egentligen innebär att undervis

The saints’ Lives written by Kyrillos (Cyril) of Skythopolis form a centrepiece in Greek hagiography, not least through the two central Lives of Euthymios and Sabas, respectively. The occurrence of lions in the Kyrillos’ narrative has been noted before, but not with respect to their eschatological and symbolic function, especially in attaching the performance of the saints to landscape and wildern

Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and relate

A higher intake of gluten during childhood is associated with increased risk of celiac disease, and the incidence of celiac disease peaks shortly after the time point when associations with higher gluten intake during the second and third year of life occur. Additional environmental factors are most likely necessary for celiac disease to develop. It is hypothesized that gastrointestinal infections

We propose a competition-based approach to resilient distributed optimization with quadratic costs in Networked Control Systems (e.g., wireless sensor network, power grid, robotic team) where a fraction of agents may misbehave (through, e.g., hacking or power outage). Departing from classical filtering strategies proposed in literature, and inspired by a game-theoretic interpretation of consensus,

Gaze-control and gaze-assistance in software development tools have so far been explored in the setting of code editing, but other developer activities like code review could also benefit from this kind of tool support.In this paper, we present GANDER, a platform for user studies on gaze-assisted code review. As a proof of concept, we extend the platform with an assistant that highlights name rela

The ability to decide and adjust actions according to motion prediction of dynamic obstacles offers a flexible planning scheme and ampler reaction time to avoid potential impact. Prediction-based collision avoidance implies a two-stage decision-making process from motion prediction to action planning. One of the challenges in motion prediction is the movements of objects are usually non-determinis

Comparing 3D neutron and X-ray microtomography (NCT and XCT) results of fully pyrolyzed and pristine samples, we observed that the contrast in the neutron images increased for the carbonized samples, suggesting that H would be concentrated at the surface of the carbonized material structure.

The characterization of structure over a wide range of length scales from atomic to microns is a common requirement for understanding the behaviour of many soft matter systems. In the case of self-assembling and colloidal materials, the final properties will depend sensitively on intermolecular as well as interparticle interactions. Experimental methods such as wide and small angle scattering, whi

We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, carboplatin is not specifically toxic to tumour cells and has been associated with neurotoxicity at high infused concentrations in pre-clinical studies. Our treatment strategy requires in

In the past few years there has been a growth in the use of nanoparticles for stabilizing lipid membranes that contain embedded proteins. These bionanoparticles provide a solution to the challenging problem of membrane protein isolation by maintaining a lipid bilayer essential to protein integrity and activity. We have previously described the use of an amphipathic polymer (poly(styrene-co-maleic

PLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective delivery of drugs, such as carboplatin, to the brain, by enabling a more sustained dosage over a longer time than otherwise possible. However, the link between the controlled release nanoparticle synthesis route, and the subsequent drug release profile obtained, is not well-understood, which hinders design o

In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ