Pseudo-guaianolides represent a large group of sesquiterpene lactones exhibiting significant cytotoxic and anti-inflammatory activities. Their biological activities are due to a 훼-methylene-훾-lactone unit in their chemical structure, which reacts with free sulfhydryl groups of free cysteine via a Michael-addition. Damsin is a major pseudo guaianolide found in Ambrosia arborescens Mill., a plant di

Purpose – The aim of this paper is to contribute with increased knowledge of the complex role of internal communication during a crisis like the COVID-19 pandemic. More specifically, the authors want to address the following research questions. How can the overall approach to internal crisis communication during the pandemic be interpreted, and what view of internal crisis communication does this

In this thesis we study the steady Euler equations in three dimensions where the solution is assumed to have nonvanishing vorticity. The thesis is based on three research papers. In the first and the third we study the steady Euler equations in the context of the water wave problem, which means we are solving a free boundary problem, while in the second paper we study the equations in a fixed cyli

A new error metric targeting rendered high dynamic range images is presented. Our method computes a composite visualization over a number of low dynamic range error maps of exposure compensated and tone mapped image pairs with automatically computed, or manually provided, parameters. We argue that our new error maps predict errors substantially better than metrics previously used in rendering. Sou

Den 28:e oktober slog Amazon.se upp dörrarna för den svenska e-handelsplatsen och experternas åsikter var delade. Amazon fick kritik för att det var ett hastverk med dåliga översättningar och att svenskarna inte skulle attraheras. I en liknande rapport som denna från december månad såg konsumenternas reaktion positiv ut (Anselmsson & Tunca, 2020). Hur ser situationen ut efter att Black Friday

Background: Defining the origin of genetic novelty is central to our understanding of the evolution of novel traits. Diversification among fatty acid desaturase (FAD) genes has played a fundamental role in the introduction of structural variation in fatty acyl derivatives. Because of its central role in generating diversity in insect semiochemicals, the FAD gene family has become a model to study

Interdiffusion and chemical reactions contribute to tool wear in metal machining. Increased understanding of these processes, through characterisation of worn tools, can facilitate design of more resilient materials through chemical and diffusional passivation. However, the unknown reaction conditions, the large number of elements, and the formation of interspersed phases makes for a complex analy

Despite sharing being a long-practiced form of consumption, the concept ‘sharing economy’ has emerged only recently. New business models have proliferated, utilising technology to reduce transaction costs and facilitate shared access. Societal actors have taken interest in the sharing economy, to reduce resource consumption, foster social cohesion, and support the economy. However, sharing economy

Background: Despite improved surgical and oncological treatment, ovarian cancer continues to be the most lethal of the gynecologic malignancies. We aimed to analyze survival trends in epithelial ovarian cancer with regard to age, tumor site, and morphology in Sweden 1960 to 2014. Methods: A nationwide population-based study was conducted using data from the Swedish Cancer Registry on 46,350 women

MAX IV Laboratory is the Swedish national particle accelerator that currently provides the world's most brilliant X-rays for research. MAX IV Laboratory has two storage rings as well as a 300-meter linear accelerator with hundreds of components not only to be relatively aligned with tight tolerances but also to be absolutely aligned with respect to the global coordinate system of the facility. An

Regression via classification (RvC) is a common method used for regression problems in deep learning, where the target variable belongs to a set of continuous values. By discretizing the target into a set of non-overlapping classes, it has been shown that training a classifier can improve neural network accuracy compared to using a standard regression approach. However, it is not clear how the set

Juvenile songbirds rely on an endogenous program, encoding direction, distance, fueling, and timing of migration. Migratory distance is species-specific, expressed as a period of migratory restlessness, for which the length is correlated with distance, while fueling is modified to meet anticipated flight distances controlled by geomagnetic cues and amount of day-light available for foraging. How d

The results of a search for direct pair production of top squarks and for dark matter in events with two opposite-charge leptons (electrons or muons), jets and missing transverse momentum are reported, using 139 fb−1 of integrated luminosity from proton-proton collisions at s = 13 TeV, collected by the ATLAS detector at the Large Hadron Collider during Run 2 (2015–2018). This search considers the

Although some neighborhood environmental factors have been found to affect depressive symptoms, few studies have focused on the impact of living in a hilly environment, i.e., land slope, on depressive symptoms among rural older adults. This cross-sectional study aimed to investigate whether a land slope is associated with depressive symptoms among older adults living in rural areas. Data were coll

Cisplatin is one of the most commonly used drugs for the treatment of various solid neoplasms, including testicular, lung, ovarian, head and neck, and bladder cancers. Unfortunately, the therapeutic efficacy of cisplatin against colorectal cancer is poor. Various mechanisms appear to contribute to cisplatin resistance in cancer cells, including reduced drug accumulation, enhanced drug detoxificati

PURPOSE: To evaluate the outcomes of total endovascular aortic arch repair using three-vessel inner branch stent-grafts for aneurysms and chronic dissections.METHODS: We reviewed the clinical data and outcomes of consecutive patients treated by total endovascular aortic arch repair at eight academic centers using three-vessel inner branch stent-grafts (William Cook Europe, Bjaeverskov, Denmark) be