Search results

The use of monoclonal antibodies (MAbs) in cytotoxic conjugates (radionuclides, toxins, or drugs) for targeting tumor cells is restricted due to toxicity in vital organs. Through improved tumor targeting, it is possible to administer larger amounts of such labeled MAbs, thus improving the ability to eradicate tumor cells without increased normal organ toxicity. Extracorporeal affinity adsorption t

Background: Foods with a low glycemic index are increasingly being acknowledged as beneficial for individuals with disorders related to the insulin resistance syndrome. The presence of certain salts of organic acids has been shown to lower the glycemic index of bread products and one of the suggested mechanisms is a lowered gastric emptying rate (GER). One obvious pitfall with many of the common t

Popular Abstract in Swedish Avhandlingen består av två delar. I den första delen används rent potentialteoretiska metoder för att studera hinderproblemet hörande till en likformigt elliptisk andra ordningens differentialoperator på divergensform. Reguljära punkter till hindren karakteriseras med det klassiska Wiener-kriteriet. Andra delen behandlar en klass av funktioner som uppfyller en viss intThe thesis consists of two parts. In the first part pure potential theoretic methods are employed to study the obstacle problem connected with a uniformly elliptic second-order differential operator in divergence form. Regular points of the obstacles are characterized by the classical Wiener criterion. The second part deals with a class of functions satisfying a certain integral inequality. A pr

BACKGROUND: The clinically important Kidd (JK) blood group antigens are carried by the urea transporter in red cells. The rare Jk(a-b-) phenotype can be caused by homozygosity at the JK locus for a silent allele, JK: This phenotype has been recorded in many ethnic groups, but it is most abundant among people originating from the Polynesian Islands and Finland. The molecular basis for Jk(a-b-) is u

The ability to perceive and express emotional, as well as number of linguistic prosodic qualities of speech was tested in 20 Swedish-speaking patients with right-sided cortical, as well as purely subcortical brain infarcts, and in 18 normal controls. The infarcts were assessed by clinical neurological examination, and by CT, EEG, and measurements of regional cerebral blood flow (rCBF). In the pati

Extraction constants for the solvent extraction of hydrofluosilicic acid with Alamine 336 have been determined. Two species were identified, (R3NH+ )2 SiF62- and R3NH+ HSiF6, whose respective extraction constants were determined to be log K21 = 7.42 and log K11 = 2.60. For the dissociation of hydrofluosilicic acid the activity coefficient model presented by Bromley was adapted to sulphuric acid an

The study considers relations in a group of 95 managers, 41 women and 54 men, between working climate of their units, their leadership styles in terms of their subordinates’ ratings of employee-centeredness, change-centeredness and production-centeredness, and their personality patterns according to the Spiral Aftereffect Technique (SAT). Eight managerial types were distinguished, based on low and

Background: Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15; 19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy. The t( 15; 19) results in the fusion oncogene BRD4-NUT. Information concerning treatment of this rare disord

A technique is presented here for evaluating the loss factor of a solid material element. This technique is commonly used in room acoustics to evaluate the reverberation time (RT) of rooms, and is therefore reviewed in this paper for applications in solid materials. The reverberation time is a quantity that describes the rate of decay of the sound level in the room, and is inversely proportional t

The size effect in shear strength of longitudinally reinforced beams is studied by means of a nonlinear fracture mechanics model. According to the actual theoretical study, structure size should be normalized to an intrinsic length parameter of the concrete. This length parameter is proportional to the fracture energy G//F of the concrete. It is found that the shear strength of a concrete beam may

The five different CP conserving amplitudes for the decays K --> 3pi are calculated using Chiral Perturbation Theory. The calculation is made to next-to-leading order and includes full isospin breaking. The squared amplitudes are compared with the corresponding ones in the isospin limit to estimate the size of the isospin breaking effects. In this paper we add the radiative corrections to the earl

Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished. However, T

The modelling of premixed turbulent combustion has been studied. Premixed turbulent combustion occurs in a range of applications, such as gas turbines and spark-ignition engines. It is important that the modelling can capture the most relevant details of the combustion in order to minimize the emissions and secure the operability already in the design process of these devices. As the simulation of

Objectives To obtain reference data representative of normal findings at anal endosonography in pregnant and non-pregnant women. To determine intraobserver and interobserver agreement in the detection of endosonographic anal sphincter defects in asymptomatic women. Methods Twenty-five non-pregnant nulliparous women and 25 non-pregnant parous women (age range, 20-67 years) and 47 pregnant women (a

This article builds on the introduction to the concept of distributed economies (DE) by Johansson et al. [Johansson A, Kisch P, Mirata M. Distributed economies - a new engine for innovation. Journal of Cleaner Production, this issue] and takes the discussion further by reviewing examples of production systems that, due to certain characteristics, can be seen as illustrative DE elements. Through se

The mechanism, thermodynamics and kinetics of light-induced cyclic electron transfer have been studied in a model energy-transducing system consisting of solubilized Rhodobacter sphaeroides reaction center/light harvesting-1 complexes (so-called core complexes), horse heart cytochrome c and a ubiquinone-0/ubiquinol-0 pool. An analysis of the steady-state kinetics of cytochrome c reduction by ubiqu