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BACKGROUND: Guidelines recommend estimation of glomerular filtration rate (eGFR) prior to iodine contrast media (CM) examinations. It is also recommended that absolute eGFR in mL/min, not commonly used relative GFR (adjusted to body surface area; mL/min/1.73 m(2)), should be preferred when dosing and evaluating toxicity of renally excreted drugs.PURPOSE: To validate the absolute Lund-Malmö equatio

Cystatin C is produced in all nucleated cells. It has various functions and biological activities. Researchers are focused on its role in kidney diseases as a marker of glomerular filtration but also as a very important link in development of amyloid diseases. This work describes expression and purification of both wild type (wt) and stabilized form (stab 1 and 2) of wt cystatin C and amyloid-form

The (1)H NMR Fast Field Cycling relaxometry was applied to study the molecular dynamics of the human protein HC (alpha (1)-microglobulin), its hydration and aggregation in solution state. The (1)H NMRD data have revealed the complex nature of the water/protein HC system resulting from the co-existence of monomer and dimer forms of the protein in solution as well as the presence of oligosaccharides

Nettoprimärproduktionen (NPP), är källan till den mat vi äter, virket vi bygger hus av och veden vi eldar med. NPP spelar också en stor roll i den globala kolcykeln, genom fotosyntesen så binder växterna koldioxid från luften och producerar blad och stammar. Hur mycket växterna producerar styrs till stor utsträckning av klimatet samt hur mycket koldioxid som finns i atmosfären. Detta gör att de föNet primary production (NPP) serves as an indicator for plant-based resources such as food, timber and biofuel for human appropriation. It is defined by the annual production of plant matter and is mainly controlled by climate and human activities. Climate change in combination with human activities is altering NPP. As the controls of NPP are expected to further change in the future, it is vital t

In 1984, Richard Ruiz set forth three orientations to language planning: language as problem, language as right, and language as resource. Since that time, the orientations have only become more powerful, rising to the level of paradigm in the field of language policy and planning (LPP). In this paper, we revisit Ruiz’s orientations. By drawing upon Ruiz’s own work as well as the work of other sch

Glioblastoma (GBM), or WHO Astrocytoma grade IV, is the most common primary brain tumour in adults. GBM is shown to escape host immune surveillance through many paths, of which expression of indoleamine 2,3-dioxygenase (IDO), leading to induction and accumulation of regulatory T-cells in the tumour microenvironment, has been shown to be of importance. 1-Methyl tryptophan (1-MT) is an inhibitor of

Using high resolution X-ray photoelectron spectroscopy and scanning tunneling microscopy we study the intercalation of hydrogen under graphene/Ir(111). The hydrogen intercalated graphene is characterized by a component in C 1s that is shifted −0.10 to −0.18 eV with respect to pristine graphene and a component in Ir 4f at 60.54 eV. The position of this Ir 4f component is identical to that of the Ir

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a short, constitutively-expressed form (sfTSLP), that appears to be downregulated by inflammation. The TSLP forms ca

Adaptor proteins assist proteases in degrading specific proteins under appropriate conditions. The adaptor protein YjbH promotes the degradation of an important global transcriptional regulator Spx, which controls the expression of hundreds of genes and operons in response to thiol-specific oxidative stress in Bacillus subtilis. Under normal growth conditions, the transcription factor is bound to

In this work, we present a trinification-based grand unified theory incorporating a global SU(3) family symmetry that after a spontaneous breaking leads to a left-right symmetric model. Already at the classical level, this model can accommodate the matter content and the quark Cabbibo mixing in the Standard Model (SM) with only one Yukawa coupling at the unification scale. Considering the minimal

This study is focused on the energy saving and indoor climate analysis of the renovation of a 1930's brick-walled building in the moderately cold climatic conditions of Malmö in southern Sweden. Three facades of the building were glassed in and the ventilation system was renewed. The purpose of this study was to investigate the effect the added glazing would have on the building's energy demand an

The atomic structure of calcium-silicate-hydrate (C1.67-S-Hx) has been studied. Atomistic C-S-H models suggested in our previous study have been revised in order to perform a direct comparison of energetic stability of the diferent structures. An extensive set of periodic structures of C-S-H with variation of water content was created, and then optimized using molecular dynamics with reactive forc

The last years have been characterized by tremendous institutional change in the university sector induced by far-reaching Higher Education Reforms (e.g. Bologna). Building on loose-coupling theory, we hypothesize that smaller universities were better able to adapt to the Higher Education Reforms of the recent years, triggering a decline in the optimal size of universities in the reform period. Us

We hypothesized that key signaling pathways of glioma genesis might enable the molecular classification of gliomas. Gene coexpression modules around epidermal growth factor receptor (EGFR) (EM, 29 genes) or platelet derived growth factor receptor A (PDGFRA) (PM, 40 genes) in gliomas were identified. Based on EM and PM expression signatures, nonnegative matrix factorization reproducibly clustered 1

The human cytomegalovirus (CMV) immediate early promoter has been extensively used to drive target gene expression in transgenic mammalian cells. DNA methylation of the CMV promoter has been shown to be the reason for a reduced promoter activity and silencing of the target gene. We have established an in vitro model system, in which human brain cancer cells (glioblastoma multiforme, GBM) were tran