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Influence of stress field of expanding and contracting plate shaped precipitate on hydride embrittlement of Zr-alloys

The stress fields of expanding (precipitation) and contracting (dissolution) hydride plates were computed by finite element method using Zr-H solid solution and hydride properties at 25, 200 and 400 degrees C for fully and semi-constrained hydride plates. For the first time simultaneous hydride expansion and matrix contraction and vice-versa have been considered in a simulation of hydride precipit

The influence of lexical aspect and input frequency in the L2 French of adult beginners

This article presents a study of the variation found in the oral production of verbs in L2 French by adult beginners with Swedish as L1. The study deals with the production of the two main forms of regular verbs in spoken French, a short form /parl/ and a long form /parle/, in present-tense and infinitive contexts. Learners at beginner stages use these two forms invariantly in both finite and non-

Monte Carlo simulations for therapy imaging

In therapy imaging there is a need to optimize imaging protocols and different correction methods for e.g. photon attenuation, contribution from scatter and other physics-related effects that limits the possibility to achieve accurate quantitative results. Physical phantom studies are important but lack flexibility and are often difficult to make patient realistic. A complement is to simulate the

A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults.

BackgroundObesity is a complex disease caused by the interplay of genetic and lifestyle factors, but identification of gene-lifestyle interactions in obesity has remained challenging. Few large-scale studies have reported use of genome-wide approaches to investigate gene-lifestyle interactions in obesity.MethodsIn the PROMIS study, a cross-sectional study based in Pakistan, we calculated BMI varia

How can we determine the molecular clock of malaria parasites?

The association of contemporary hosts and their parasites might reflect either cospeciation or more recent shifts among existing hosts. Cospeciation implies that lineages of hosts and parasites diverge in parallel at the same time, but testing this prediction requires time-calibrated phylogenies, which are particularly difficult to obtain in organisms that leave few fossils. It has successively be

Photo-induced fluorescence quenching in conjugated polymers dispersed in solid matrices at low concentration

When isolated conjugated polymer (CP) chains are studied by single molecule spectroscopy, excitation power density in the range of 10-1000 W cm(-2) is normally used. We show that at such excitation power densities the fluorescence ability of CPs is significantly reduced. A new methodological approach allowed us to measure the fluorescence quantum yield (QY) of thin matrix polymer films doped with

Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study.

Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in total cholesterol (TC) and triglyceride (TG) levels in a population-based prospective cohort from Northern Sweden (the GLACIER Study). We sought replication in a southern

PANICCA - PANIC on Cross-Section Averages

The cross-section average (CA) augmentation approach of Pesaran (A simple panel unit root test in presence of cross-section dependence. Journal of Applied Econometrics 2007; 22: 265–312) and Pesaran et al. (Panel unit root test in the presence of a multifactor error structure. Journal of Econometrics 2013; 175: 94–115), and the principal components-based panel analysis of non-stationarity in idios

Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma

P>The efficacy and safety of zanolimumab (HuMax-CD4) in patients with relapsed or refractory peripheral T Cell lymphoma (PTCL) was evaluated. Twenty-one adult patients with relapsed or refractory CD4+ PTCL of non-cutaneous type (angioimmunoblastic T cell lymphoma (AITL) n = 9, PTCL-not otherwise specified (NOS) n = 7, anaplastic large cell lymphoma (ALCL) n = 4 and enteropathy type T cell lymphoma

Expression and localization of serotonin receptors in human breast cancer.

The aim of this study was to examine the expression of serotonin receptors in patients with breast cancer and to explore their utility as diagnostic and prognostic markers. Immunohistochemical analysis was performed to examine the expression of serotonin (5-HT) receptor subtypes 1A, 1B, 2B and 4 in a tissue microarray containing tumor specimens from 102 patients. Statistical analysis was performed

Temperature-Dependent Infrared Spectroscopy of Proton-Conducting Hydrated Perovskite BaInxZr1-xO3-x/2 (x=0.10-0.75)

We investigate the temperature dependence of the O-H stretch band in the infrared absorbance spectra of the proton-conducting hydrated perovskites BaInxZr1-xO3-x/2 (x = 0.10-0.75) over the temperature range -160 to 350 degrees C. Upon increasing temperature from -160 to 30 degrees C, we show that there is a redistribution of protons from nonsymmetrical structural configurations, such as Zr-OH-In a

Maternal body mass index and duration of labor

Objective: To evaluate whether the duration of the active phase of labor is associated with maternal body mass index (BMI), in nulliparous women with spontaneous onset of labor. Study design: Historical prospective cohort study including 63,829 nulliparous women with a singleton pregnancy and a spontaneous onset of labor, who delivered between January 1, 1995 and December 31, 2009. Data were colle

Evaluation of viscoelastic poly(ethylene glycol) sols as vitreous substitutes in an experimental vitrectomy model in rabbits

The aim of this study was to employ an experimental protocol for in vivo evaluation of sols of 5 wt.\% poly(ethylene glycol) (PEG) in phosphate buffered saline (PBS) as artificial vitreous substitutes. A 20 gauge pars plana vitrectomy and posterior vitreous detachment were performed in the right eye of 8 pigmented rabbits. Approximately 1 mL of the viscoelastic PEG sols were then injected into the

Comparison of MM/GBSA calculations based on explicit and implicit solvent simulations.

Molecular mechanics with generalised Born and surface area solvation (MM/GBSA) is a popular method to calculate the free energy of the binding of ligands to proteins. It involves molecular dynamics (MD) simulations with an explicit solvent of the protein-ligand complex to give a set of snapshots for which energies are calculated with an implicit solvent. This change in the solvation method (explic

The structure of star clusters in the outer halo of M31

We present a structural analysis of halo star clusters in M31 based on deep Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) imaging. The clusters in our sample span a range in galactocentric projected distance from 13 to 100 kpc and thus reside in rather remote environments. Ten of the clusters are classical globulars, whilst four are from the Huxor et al. population of extended, ol

Biasing moral decisions by exploiting the dynamics of eye gaze

Eye gaze is a window onto cognitive processing in tasks such as spatial memory, linguistic processing, and decision making. We present evidence that information derived from eye gaze can be used to change the course of individuals’ decisions, even when they are reasoning about high-level, moral issues. Previous studies have shown that when an experimenter actively controls what an individual sees