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alpha-synuclein: amyloid fibrils and interactions with lipid membranes

The second most common neurodegenerative disease, Parkinson’s disease, is linked with an amyloid forming protein, alpha-synuclein. Hallmarks of Parkinson’s disease are progressive loss of dopaminergic neurons and accumulation of intraneuronal inclusions termed Lewy bodies. Major components of Lewy bodies are amyloid fibrils formed by alpha-synuclein and various lipids and cell organelles. In this

The role of psychological factors in oncology nurses' burnout and compassion fatigue symptoms

Purpose This study explored the role of several psychological factors in professional quality of life in nurses. Specifically, we tried to clarify the relationships between several dimensions of empathy, self-compassion, and psychological inflexibility, and positive (compassion satisfaction) and negative (burnout and compassion fatigue) domains of professional quality of life. Methods Using a cros

Empathy and feelings of guilt experienced by nurses : A cross-sectional study of their role in burnout and compassion fatigue symptoms

Aims The main goal of this study was to explore the relationships between empathy, empathy-based pathogenic guilt and professional quality of life (burnout and compassion fatigue). We aim to test a model in which we hypothesize that when empathic feelings are related to pathogenic guilt, burnout and compassion fatigue symptoms may be increased. Background Empathy is at the core of nursing practice

Effectiveness of a mindfulness-based intervention on oncology nurses’ burnout and compassion fatigue symptoms : A non-randomized study

Background Job stress and burnout are highly frequent in healthcare professionals, and prevalence in nurses can be as high as 40%. Mindfulness-based interventions have been shown to be effective in reducing stress and increasing well-being in a wide range of populations and contexts. However, controlled studies with healthcare professionals, and especially nurses, are scarce. Objectives, design an

Focusing on self or others has different consequences for psychological well-being : A longitudinal study of the effects of distinct interpersonal goals

A longitudinal study examined the association between interpersonal goals (selfimage and compassionate goals) and depression, anxiety, and stress symptoms. We propose that having self-image goals (trying to create and manage a positive image) may lead to psychological distress, while genuinely taking others' needs into account and caring for their welfare (compassionate goals) may promote psycholo

Exploring Self-criticism : Confirmatory Factor Analysis of the FSCRS in Clinical and Nonclinical Samples

The Forms of Self-criticizing/Attacking and Self-reassuring Scale (FSCRS) is a self-report questionnaire that assesses the forms of self-criticism and self-reassurance. The aim of this study was to explore the latent structure of the FSCRS in nonclinical and clinical samples. Data from 381 participants from the general population and from 304 participants from clinical settings were subjected to c

The impact of illness-related shame on psychological health and social relationships : Testing a mediational model in students with chronic illness

This study explores the impact of illness-related shame on the quality of social relationships and psychological health in chronic patients. We aimed to examine the roles of fear of receiving compassion from others and experiential avoidance as potential mediators of this relationship. Although some studies have demonstrated the negative impact of chronic illness-related shame on psychological fun

BEfree : A new psychological program for binge eating that integrates psychoeducation, mindfulness, and compassion

Binge eating disorder (BED) is associated with several psychological and medical problems, such as obesity. Approximately 30% of individuals seeking weight loss treatments present binge eating symptomatology. Moreover, current treatments for BED lack efficacy at follow-up assessments. Developing mindfulness and self-compassion seem to be beneficial in treating BED, although there is still room for

The Origins of Fears of Compassion : Shame and Lack of Safeness Memories, Fears of Compassion and Psychopathology

Empirical and clinical research suggests that some individuals find self-generating compassion and receiving compassion from others difficult and aversive. However, it is unclear how these fears of compassion are linked to early experiences and to psychopathological symptoms. This study explores the relationship between shame traumatic memories, centrality of shame memories, early memories of warm

Incorporating psychoeducation, mindfulness and self-compassion in a new programme for binge eating (BEfree) : Exploring processes of change

This study explores the efficacy of BEfree, a 12-session group intervention that integrates psychoeducation, mindfulness, compassion and value-based action, in a sample of overweight and obese women with binge eating disorder (N = 31). We used repeated measures analyses of variance and explored processes of change in binge eating and eating psychopathology. At post-intervention, participants decre

Evaluating the Multifactor Structure of the Long and Short Versions of the Self-Compassion Scale in a Clinical Sample

Objective: There has been a growing interest in the concept of self-compassion in Eastern psychology. The aim of the present study was to explore the dimensionality of the widely used Self-Compassion Scale (SCS; long and short versions) in both clinical and nonclinical samples Method: Several confirmatory factor analyses (CFAs) were computed in a mixed clinical (n = 316) and a nonclinical sample (

Skill-biased acquisitions? Human capital and target employee mobility in small technology firms

The purpose of this study is to investigate the relationship between acquisitions and mobility of knowledge workers and managers in small technology companies and how individual skills and capabilities moderate the relationship. Relying on the matched employer-employee data of the Swedish high-tech sectors from 2007 to 2015, we find that acquisitions increase the likelihood of employee departures,

Predicting Glycemia in Type 1 Diabetes Mellitus with Subspace-Based Linear Multistep Predictors

A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The accurate prediction of blood glucose levels in response to inputs would support the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this bac

Towards a unified theory of market prices: turning to pricing in practice

This article proceeds from the question: how do prices in markets work? In socioeconomic theories, I find two answers to this question. The structural-coordinative approach explains prices as outcomes—coordinative effects of pricing scripts installed by exogenous, institutionalized social structures. The performative-epistemological approach explains prices as market devices—endogenous performativ

The effect of postoperative anticoagulation on false lumen patency after surgery for acute type A aortic dissection

Background: Patent false lumen has been shown to have a negative impact on prognosis after surgery for acute type A aortic dissection (ATAAD). We aimed to assess the effect of postoperative anticoagulation on false lumen patency and clinical outcomes in relation to false lumen status. Methods: Postoperative computed tomographies of 156 patients undergoing ATAAD DeBakey type I surgery were retrospe

Quantitative Measures for Recognition of Negotiation Style and Activity

Group Decision and Negotiation Support Systems need to provide support for different types of communication activities. The purpose of this study is to identify and test cross-linguistic measures for recognition of communication activities in order to provide support for various forms of group decision and negotiation support systems, including e-negotiation support systems. The study uses quantit