A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and mediates the left-right side-specific effects of unilateral brain lesions. In rats with completely transected thoracic spinal cords, unilateral injury to the sen

Ongoing climate variability and change are increasing the burden of diarrhoeal disease worldwide. Meaningful early warning systems with adequate lead times (weeks to months) are needed to guide public health decision–making and enhance community resilience against health threats posed by climate change. Toward this goal, we trained various machine-learning models to predict diarrhoeal disease rate

Heatwaves are the deadliest weather hazard and people and societies across the world continue to suffer from heat-related impacts. Future climate projections show a troubling increase in cross-sectoral impacts including health and economic risk presented by heatwaves. Many weather hazards such as floods and droughts already have a type of Early Warning System (EWS) or Global Alert System, but a gl

The notion of error plays an important role, this article argues, in Per Olov Enquist’s ground-breaking documentary novel Legionärerna (The Legionnaires) (1968), which depicts the controversial Swedish extradition of Baltic soldiers in January 1946. In terms of the plot (re)constructed by Enquist, Swedish politicians and Baltic soldiers as well as the novel’s investigator, a kind of alter ego of t

Om drottning Kristina.

Neuroblastoma (NB) is one of the most lethal childhood cancers due to its propensity to become treatment resistant. By spatial mapping of subclone geographies before and after chemotherapy across 89 tumor regions from 12 NBs, we find that densely packed territories of closely related subclones present at diagnosis are replaced under effective treatment by islands of distantly related survivor subc

BackgroundUnderstanding the heterogeneity of opioid overdose fatalities is critical to developing effective preventive interventions. This study examines patterns of care contacts among people who subsequently died from opioid overdose. The aim was to identify distinct groups of deceased individuals, based on their contacts with different care agencies in their last year of life.MethodsA retrospec

Andelen engelskspråkig undervisning och kurslitteratur ökar hela tiden på svenska universitet och högskolor. Men det finns mycket lite stöd för att det skulle gynna kvaliteten på utbildningen. Däremot finns det gott om forskning som indikerar motsatsen.

Lärarna underpresterar och studenternas lärande försämras. Så blir det när undervisningen sker på ett språk som varken är lärarnas eller studenternas modersmål, skriver förläggaren Ola Håkansson och forskaren Peter Svensson.

Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more Objective: To evaluate hand and arm function and its association with motor symptoms as well as activities of daily living (ADL) in de novo Parkinson’s disease (PD).Background: Motor symptoms and disability in upper limb are common in PD and usually assessed using Unified PD Rating Scale (UPDRS). Activities, like reaching, grasping, manipulating objects, writing, dressing, and eating, may be more

BACKGROUND: Accumulating studies reported that several phosphodiesterases (PDEs) inhibitors might have cardiovascular benefits.OBJECTIVES: This study aimed to explore the relationship between genetically-predicted PDEs and ischemia heart disease via drug target Mendelian randomization (MR) approach, and then examine the effect of inhibitors of identified target on the outcomes by using real-world

Om Vilhelm av Ruysbroeck.

BACKGROUND: Hypothermia and acidosis individually inhibit haemostasis. We designed this study with the aim to investigate whether rivaroxaban combined with hypothermia or acidosis exhibit synergistic inhibitory effects on haemostasis using ROTEM ®. METHODS: Patients with a clinical indication to start rivaroxaban treatment were prospectively included. Blood samples were collected before initiation

Nonvolatile memory devices based on ferroelectric HfxZr1-xO2 (HZO) show great promise for back-end integrable storage and for neuromorphic accelerators, but their adoption is held back by the inability to scale down the HZO thickness without violating the strict thermal restrictions of the Si CMOS back end of line. In this work, we overcome this challenge and demonstrate the use of nanosecond puls

BackgroundSweden reached the UNAIDS 90-90-90 target in 2015. It is important to reassess the HIV epidemiological situation due to ever-changing migration patterns, the roll-out of PrEP and the impact of the COVID-19 pandemic.AimWe aimed to assess the progress towards the UNAIDS 95-95-95 targets in Sweden by estimating the proportion of undiagnosed people with HIV (PWHIV) and HIV incidence trends.M

The concept of regional anchor firms remains under-investigated. We analyse the mechanisms by which anchors affect other regional firms, disentangling effects resulting from scale/size vis-à-vis knowledge spillovers. Departing from previous idiographic research, we adopt a nomothetic research design and develop a stepwise expert-informed supervised machine learning approach to identify all anchor