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Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations of coding polymorphisms at minor allele frequencies (MAFs) > 1% with common metabolic phenotypes. The study comprised three stages. We performed medium-depth (8x) whole exome sequencing in 1,000 cases with type 2 diabetes, BMI > 27.5 kg/m(2) and hypertension

Intranasal cooling with or without intravenous cold fluids during and after cardiac arrest in pigs

Background Intranasal balloon catheters circulated with cold saline have previously been used for the induction and maintenance of selective brain cooling in pigs with normal circulation. In the present study, we investigated the feasibility of therapeutic hypothermia initiation, maintenance and rewarming using such intranasal balloon catheters with or without addition of intravenous ice-cold flui

Talking About Sexuality: Desire, Virility, and Intimacy in the Context of Prostate Cancer Associations

Prostate cancer and its outcomes are a real threat for health and well-being for men living in the Western world. The number of men with a diagnosis of prostate cancer, before the age of 65 years, has increased in recent decades. The aim of this study was to explore how some of these Swedish men experienced and talked about their sexuality. Four focus group discussions were performed in the contex

RNA interference screening to detect targetable molecules in hematopoietic stem cells.

The molecular principles regulating hematopoietic stem cells (HSCs) remain incompletely defined. In this review, we will discuss how RNA interference (RNAi) screening has emerged as a new and powerful tool to molecularly dissect various functional aspects of both normal and malignant HSCs, and how this may ultimately enable the discovery of novel therapeutic targets for clinical applications.

Strategy-proof voting for multiple public goods

In a voting model where the set of feasible alternatives is a subset of a product set A of m finite categories, we characterize the set of all strategy-proof social choice functions for three different types of preference domains over A, namely for the domains of additive, completely separable, and weakly separable preferences over A.

Efficient Adaptive and Dynamic Mesh Refinement Based on a Non-recursive Strategy

In this paper, we present a meshing scheme for the implementation of an adaptive tessellation of triangular meshes on the graphics processing unit (GPU). Tessellation is performed according to a local test to generate primitives dynamically. The refinement procedure does not require the pre-computation of any refinement pattern. The resulting adaptive procedure is efficient and simple, and generat

Conceptions of how a learning or teaching curriculum, workplace culture and agency of individuals shape medical student learning and supervisory practices in the clinical workplace.

The role of workplace supervisors in the clinical education of medical students is currently under debate. However, few studies have addressed how supervisors conceptualize workplace learning and how conceptions relate to current sociocultural workplace learning theory. We explored physician conceptions of: (a) medical student learning in the clinical workplace and (b) how they contribute to stude

New types of employment, new ways to be uncivil? A thematic analysis of temporary agency workers’ exposure to workplace incivility

The aim of the study was to explore what types of incivility temporary agency workers might experience or witness. A total of 162 temporary agency workers (97 women and 65 men) from three unions and three temporary work agencies completed an online questionnaire. The questionnaire consisted of a one-item question, with an open-ended response format, regarding what types of incivility temporary age

Spatially conserved regulatory elements identified within human and mouse Cd247 gene using high-throughput sequencing data from the ENCODE project.

The Cd247 gene encodes for a transmembrane protein important for the expression and assembly of TCR/CD3 complex on the surface of T lymphocytes. Down-regulation of CD247 has functional consequences in systemic autoimmunity and has been shown to be associated with Type 1 Diabetes in NOD mouse. In this study, we have utilized the wealth of high-throughput sequencing data produced during the Encyclop

3D Spectroscopy of Vibrational Coherences in Quantum Dots: Theory.

In semiconductor nanocrystals, called quantum dots (QD), electronic transition energies, phonon frequencies, and electron-phonon coupling strengths are all reported to depend on the size of the crystals. The size dependencies of the transition energies and the mode frequencies are well characterized and understood. At the same time, the electron-phonon coupling dependence on size is controversial-

Combat Stress Disorders and Their Treatment in Ancient Greece

Every disorder is embedded within multiple sociocultural aspects, and in mental disorders they acquire paramount significance. Nonetheless and despite the cultural diversity of ancient and modern societies, the consistency of psychiatric reactions to combat stress throughout history is remarkable. The situation in ancient Greece was quite different from the contemporary one. Hippocratic physicians

Sociodemographic, psychiatric and somatic risk factors for suicide: a Swedish national cohort study

Background More effective prevention of suicide requires a comprehensive understanding of sociodemographic, psychiatric and somatic risk factors. Previous studies have been limited by incomplete ascertainment of these factors. We conducted the first study of this issue using sociodemographic and out-patient and in-patient health data for a national population. Method We used data from a national c

Characterization of cyclodextrin glycosyltransferases (CGTases) and their application for synthesis of alkyl glycosides with oligomeric head group

Cyclodextrin glycosyltransferases (CGTases) from Paenibacillus macerans, Thermoanaerobacter sp. ATCC 53627, Bacillus stearothermophilus and a Carboxydocella sp. (phylogenetically identified from genomic DNA) were characterized with respect to their catalytic activity in different reactions, with emphasis on reactions useful for the elongation of the carbohydrate group of alkyl glycosides. All CGTa

Observation of a Centrality-Dependent Dijet Asymmetry in Lead-Lead Collisions at root s(NN)=2.76 TeV with the ATLAS Detector at the LHC

By using the ATLAS detector, observations have been made of a centrality-dependent dijet asymmetry in the collisions of lead ions at the Large Hadron Collider. In a sample of lead-lead events with a per-nucleon center of mass energy of 2.76 TeV, selected with a minimum bias trigger, jets are reconstructed in fine-grained, longitudinally segmented electromagnetic and hadronic calorimeters. The tran

Molecular Rift: Virtual Reality for Drug Designers

Recent advances in interaction design have created new ways to use computers. One example is the ability to create enhanced 3D environments that simulate physical presence in the real world a virtual reality. This is relevant to drug discovery since molecular models are frequently used to obtain deeper understandings of, say, ligand protein complexes. We have developed a tool (Molecular Rift), whi

Regional differences in birth size: a comparison between the Helsinki Birth Cohort Study and contemporaneous births on the Åland Islands.

The Åland Islands were recently ranked as Finland's healthiest region with lower prevalence of several non-communicable diseases compared with the national mean. We have compared birth characteristics of 1697 individuals born on the Åland Islands between 1937 and 1944 with contemporaneous data from the Helsinki Birth Cohort Study (HBCS; n=11,808). This is a first step towards a potential future an

Parental Education and Offspring Outcomes: Evidence from the Swedish Compulsory School Reform

We use the Swedish compulsory school reform to estimate the causal effect of parental education on sons’ outcomes. To this end, we use data from the Swedish military enlistment register on the entire population of males and consider outcomes such as cognitive skills, non-cognitive skills, and various dimensions of health at the age of 18. We find positive effects of maternal education on sons' ski