The intracellular signal cascade transducing muscarinic-receptor-stimulation to gene expression was investigated in human neuroblastoma SH-SY5Y cells. Naive and ethanol-exposed SH-SU5Y cells were stimulated with carbachol (CCh) and inositol 1,4-5-trisphosphate (IP3), 1,2-diacylglycerol (DAG), and c-fos mRNA levels were analyzed using a radioreceptor assay (IP3) thin-layer chromatography (DAG) and

The adhesion receptor CD-31 is expressed on neutrophils and endothelial cells and participates in transendothelial migration of neutrophils. Although necessary, information on CD-31-induced signaling and its influence on the shape-forming actin network is scarce. Here, we found that antibody engagement of CD-31 on suspended neutrophils triggered a prompt intracellular Ca(2+) signal, providing the

Popular Abstract in Swedish I Sverige har intranät inom loppet av ett par år införts i drygt hälften av alla organisationer – privata och offentliga. Intranät har av många setts som ett verktyg för att effektivisera kommunikationen och lärandet. Behovet av effektiv kommunikation och lärande har accelererat under 1990-talet med en allt större konkurrens mellan organisationerna. En god tillgång tillDuring the 1990s, communication and learning attracted heightened attention in organizational contexts. Generally speaking, there is great faith in the significance of ICT for people’s learning. One form of technology which has had a great impact on Swedish organizations is the intranet. Within the course of a few years, intranets have been implemented in just over half of all Swedish organization

The fundamental question posed in this study is how to approach the construction sector in order to cover its wide scope of activities, its great variety of actors and the external influences on it from the market and institutional environment. Construction includes such diverse economic activities as new production and as repair/maintenance, itinerant production and stationary manufacture, the pr

Low-temperature experiments are performed on nanoscale nonlinear devices (ballistic rectifiers) as well as nanostructured artificial materials, fabricated from an InP/InGaAs quantum well wafer. A dc output is generated between the lower and upper contacts of these devices, when an ac voltage is applied between the left and right contacts. As the temperature is lowered from room temperature, the dc

In the transition from curative treatment to palliative care of a general end-of-life patient population, the internal communication of the acute care staff seems to be less than optimal. The communication had reference to the dialogue within the staff both before and after the decision to concentrate on palliative care, and possible transfer of the patient. This survey of Swedish nurses and physi

A gender difference in the glucagon response to insulin-induced hypoglycemia was previously demonstrated in humans. Whether this reflects a gender difference in autonomic activation or in pancreatic alpha-cell regulation is not known. We investigated the glucagon, epinephrine, and norepinephrine responses to neuroglycopenic stress induced by 2-deoxy-D-glucose (2-DG) or insulin in female and male m

Paper A investigates how to simulate a differentiated mean in cases where interchanging differentiation and expectation is not allowed. Three approaches are available, finite differences (FD's), infinitesimal perturbation analysis (IPA) and the likelihood ratio score function (LRSF) method. We study FD's under discontinuities and show that the optimal decay rate of the mean square error is typical

A study of some of the most (in)famous text forgeries in history: the Ems telegramme, the Constantinian Donation, fibula Praenestina, and anonymous letters in the 1950-ies, and others.

Acquired aplastic anemia (AA) is considered to be an autoimmune mediated disease whereas in inherited bone marrow failure syndromes the genetic abnormalities account for the bone marrow dysfunction. The only curative treatment for inherited AA is hematopoietic stem cell transplantation (HSCT). Successful treatment for acquired AA has traditionally been considered with HSCT, whereas single agent th

objectives: To assess the level of infectious complications and the impact of timing of a single, prophylactic, oral dose of ciprofloxacin 750 mg given either 2 hours before or in conjunction with ultrasound -guided core biopsy of the prostate in men without recognised risk factors and to analyse potential risk factors. Methods: All men undergoing prostate biopsy for elevated prostate specific ant