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Objective: To investigate changes in opioid use after supervised exercise therapy and patient education among knee or hip osteoarthritis patients with chronic opioid use. Method: In this cohort study, we linked data from the Good Life with osteoArthritis in Denmark register (GLA:D®; standardised treatment program for osteoarthritis; January 2013 to November 2018) with national health registries. A

Wetlands provide many benefits, such as water storage, flood control, transformation and retention of chemicals, and habitat for many species of plants and animals. The ongoing degradation of wetlands in the Great Lakes basin has been caused by a number of factors, including climate change, urbanization, and agriculture. Mapping and monitoring wetlands across such large spatial and temporal scales

We are developing techniques for studying the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities in a planar geometry at high-energy-densities at the National Ignition Facility (NIF). In particular, through the improvement of experimental imaging quality, we are progressing toward the study of the turbulent regime of the mixing regions in capsule implosion experiments for inertial confi

While in Modern Italian, V1 is mandatory in absolute constructions, no such restriction is operative in Old Italian. On the surface, such a fact could be interpreted as a sign of residual V-to-Comp movement in Modern Italian. However, it is not: In Old Italian, participles targeted a position lower than Comp and, hence, the V1 pattern of Modern Italian is an innovation rather than a residue from t

Introduction. With the ever-increasing presence of digital technology and media, scholars have explored the cross-articulations of infrastructure and platform to investigate the contemporary digital landscape. However, cross-articulations of the two concepts vary according to the empirical setting and focus. The present paper investigates the ways the two concepts relate to each other and their re

Brain damage is the major cause of permanent disability and it is particularly relevant in the elderly. While most studies focused on the immediate phase of neuronal loss upon injury, much less is known about the process of axonal regeneration after damage. The development of new refined preclinical models to investigate neuronal regeneration and the recovery of brain tissue upon injury is a major

Both the Swedish verb hinna and the Norwegian verb rekke have been shown to encode complex sufficiency meanings involving temporal sufficiency and ability (‘have enough time to be able to do sth’) (Johansson & Nordrum, 2016, 2021), but differ in that hinna always encodes temporal meaning while rekke also has spatial meaning. Interestingly, a third Mainland Scandinavian language, Danish, can al

In this article, I use a broad brush to provide a big picture of a corporate brand, how corporate branding works, and what it takes to manage a corporate brand. In the movie The Matrix, Mr. Anderson is invited to come behind the scenes to see and experience a world beyond the projected image. My article’s title welcomes you to discover and experience a corporate brand’s reality with its opportunit

Previous research has extensively explored the role of anxiety, disgust, guilt, and shame in obsessive-compulsive (OC) symptoms, but few studies have investigated anger and associated vengeful motivations, especially during adolescence, when OC symptoms typically onset. This is unfortunate as anger is a key human emotion linked to various aspects of behaviour. Our aim was to explore how anger and

This paper discusses challenges, experiences and lessons learned so far while transforming a masonry build system based mostly on manual labour into a robot automated build system. Our motivation for selection of this masonry process is to try out how robot automation could impact the architects in their design work by providing a tool to directly manipulate wall expression down to individual bric

In vivo, apolipoprotein A-I (ApoA-I) is commonly found together with lipids in so-called lipoprotein particles. The protein has also been associated with several diseases—such as atherosclerosis and amyloidosis—where insoluble aggregates containing ApoA-I are deposited in various organs or arteries. The deposited ApoA-I has been found in the form of amyloid fibrils, suggesting that amyloid formati

Bakgrund och syfteProjektet har initierats för att kunna verifiera och påvisa värde av s.k. Mixed Reality och HoloLens inom sjukvården i Sverige samt den kliniska verksamheten.Det finns enstaka ställen i världen där HoloLens 2 används kliniskt. Region Skåne har identifierat möjligheten att HoloLens 2 kan understötta specialistinvolvering på akutmottagningen och möjlighet för specialistinvolvering

As people age the home environment becomes increasingly important. Retirement commonly leads to spending more time in one’s home, and relocating from your own home in older age could be associated with reduced health or wellbeing. The relationship between home and person is complex and perceived aspects of one’s housing such as social, emotional and cognitive ties are considered important factors

Introduction: Secondary stroke prevention depends on proper identification of the underlying etiology and initiation of optimal treatment after the index event. The aim of the NOR-FIB study was to detect and quantify underlying atrial fibrillation (AF) in patients with cryptogenic stroke (CS) or transient ischaemic attack (TIA) using insertable cardiac monitor (ICM), to optimise secondary preventi

När vi söker kunskap rör vi oss längs horisonter av icke-vetande. I en sådan bildningsresa slår vi i det här kapitlet följe med filosofen Jonna Bornemark. Den sociala barnavården är ett fält där alltmer kunskap bildas. Men hur går det till? Den här texten handlar om kunskapssökande inom socialt arbete, närmare bestämt familjehemsvård. Att söka kunskap är att göra en mängd val och överväganden. Med

It has been very difficult to predict the development of the COVID-19 pandemic based on mathematical models for the spread of infectious diseases, and due to major non-pharmacological interventions (NPIs), it is still unclear to what extent the models would have fit reality in a “do nothing” scenario. To shed light on this question, the case of Sweden during the time frame from autumn 2020 to spri

In their recent commentary in Protein Science, Jaskolski et al. analyzed three randomly picked diffraction data sets from fragment-screening group depositions from the PDB and, based on that, they claimed that such data are principally problematic. We demonstrate here that if such data are treated properly, none of the proclaimed criticisms persist.

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by enhanced platelet clearance and defective platelet production. Diagnosis by exclusion and trial-and-error treatment strategies is common practice, and despite the advancement in treatment options, many patients remain refractory. Although the existence of different pathophysiological entities is acknowledged, we are still far

In addition to their hemostatic role, platelets play a significant role in immunity. Once activated, platelets release extracellular vesicles (EVs) formed by the budding of their cytoplasmic membranes. Because of their heterogeneity, platelet EVs (PEVs) are thought to perform diverse functions. It is unknown, however, whether the proteasome is transferred from platelets to PEVs or whether its func