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Diffusion rates in a dense matrix of methane-producing microorganisms

The diffusion rate of a species, in a dense matrix of methane-producing microorganisms, was determined experimentally. To this end, a specially designed diaphragm diffusion cell was utilized. The experimental results revealed that the effective diffusion coefficient in a microorganism matrix was 22–33% of the diffusion coefficient in pure water.

Multiple risk intervention trial in high risk hypertensive men: comparison of ultrasound intima-media thickness and clinical outcome during 6 years of follow-up

OBJECTIVES: The objective was to analyse whether a favourable change in risk factors, caused by a comprehensive risk factor modification programme, affected intima-media thickness (IMT) in the common carotid artery, and whether any such change was associated with a change in cardiovascular events during a 6-year follow-up. DESIGN: Patients were randomized 1 : 1 to special intervention or usual car

Evaluation of a Probing Feeding Strategy in Large Scale Cultivations

This report presents the results of two \emph{Escherichia~coli} cultivations performed in a large scale industrial bioreactor. The experiments aimed at evaluating a probing feeding strategy that adresses the problem of acetate accumulation. The principle is to superimpose short pulses in the glucose feed and evaluate the response in the dissolved oxygen signal for the feed adjustments. Simulations

A short guide to the theory of the sublime

The article concerns selected important issues of poetics and its history. The authors analyze and interpret the history of the notion of the sublime. The article is an introduction to a theoretical part of a book about a possible theory of the literary work of art and communication that results from the experience of the sublime. The introductory article presents to the reader questions which are

Supercritical Fluids as Alternative, Safe, Food-Processing Media: An Overview.

The continuous growth of world population and its concentration in the urban areas require food supplies that are continuous, sufficient and of good quality. To resolve this problem techniques have been developed for increasing food quantity and quality. The techniques are applied throughout the food chain from production, conservation and during distribution to the consumers (from "the field to t

Resistens mot acetylsalicylsyra - klinisk diagnos utan klarlagd mekanism

A review on the subject of aspirin resistance and its role in vascular diseases is presented. Although the clinical diagnosis of aspirin resistance is frequently made, little is known about its biochemical background. Only a few follow-up studies, with varying design, have dealt with the possible association between an aspirin resistant phenotype and clinical outcome in patients with atherothrombo

Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus

Background: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin- like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases. Objective: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that com

5-(2 '-oxoheptadecyl)-resorcinol and 5-(2 '-oxononadecyl)-resorcinol, cytotoxic metabolites from a wood-inhabiting basidiomycete

5-(2'-oxoheptadecyl)-resorcinol (1) and 5-(2'-oxononadecyl)-resorcinol (2) were isolated from fermentations of an imperfect basidiomycete. The structures of the compounds were determined by spectroscopic techniques. Both compounds exhibit cytotoxic effects against the human colon tumor cell lines COLO-320, DLD-1 and HT-29 and the human promyeloid leukemia cell line HL-60, the human leukemia T cell

Clinical decision-making during 5 years of antipsychotic treatment

Objective: Explore how clinicians select drug treatment based on symptoms, side effects and patient factors, including patient participation in the process, and the association between these factors and attitudes towards drugs. Method: A cohort of 166 patients initially treated with risperidone was followed with yearly assessments over 5 years. At the end of the study, 101 patients were evaluated

Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets

Insulin induced phosphorylation and activation of the cGMP inhibited cAMP phosphodiesterase (cGI-PDE) in human platelets were demonstrated after isolation of the enzyme with specific polyclonal cGI-PDE antibodies. The demonstration of this insulin effect required suppression of basal cGI-PDE phosphorylation, through the use of the protein kinase inhibitor H-7 (1-(5-isoquinolinylsulfonyl)-2-methylp

Intact stones or fragments? Potential pitfalls in the imaging of patients after biliary extracorporeal shock wave lithotripsy

Ultrasound is used after extracorporeal shock wave lithotripsy of gallbladder stones to assess fragmentation. In many patients with apparently successful fragmentation, the posttreatment studies show an intraluminal, echogenic focus within the gallbladder, with posterior acoustic shadowing characteristic of an intact stone. Cholesterol gallstones were fragmented in vitro by means of lithotripsy, a

New scale factors for harmonic vibrational frequencies using the B3LYP density functional method with the triple-xi basis set 6-311+G(d,p)

We have calculated optimal frequency scaling factors for the B3LYP/ 6-311+G(d,p) method for fundamental vibrational frequencies on the basis of a set of 125 molecules. Using the new scaling factor, the vibrational frequencies calculated with the triple-zeta basis set 6-311+G(d,p) give significantly better accuracy than those calculated with the double-zeta 6-31G(d) basis set. Scale factors were al

Cellular and behavioural effects of the adenosine A2a receptor antagonist KW-6002 in a rat model of l-DOPA-induced dyskinesia.

We have examined the ability of KW-6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of l-DOPA in 6-hydroxydopamine-lesioned rats. In animals rendered dyskinetic by a previous course of l-DOPA treatment, KW-6002 did not elicit any abnormal involuntary movements on its own, but failed to reduce the severity of dyskinesia when coadministered with l-DOPA. A second experiment was u

Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets

The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated

Predictive models for accidents on urban links - A focus on vulnerable road users

Much of earlier work on predictive models for accidents has been focused on rural traffic or urban intersections. This work has aimed at identifying and investigating possible improvements to predictive models for accidents on urban links. A special focus has been on the accidents of vulnerable road users. The possible improvements investigated have been: a) the use of exposure data for vulnerabl

Analysis of a sub-proteome which co-purifies with and is phosphorylated by the Golgi casein kinase

In an attempt to gain information about the identity of the Golgi apparatus casein kinase(s) (G-CK), responsible for the phosphorylation of caseins in lactating mammary gland, the proteins present in fractions enriched in G-CK activity eluted from DEAE-Sepharose and heparin-Sepharose columns were resolved by two-dimensional electrophoresis and analyzed by mass spectrometry. This led to the identif