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Traumatic brain injury (TBI) often leads to impaired regulation of cerebral blood flow, which may be caused by pathological changes of the vascular smooth muscle cells (VSMCs) in the arterial wall. Moreover, these cerebrovascular changes may contribute to the development of various neurodegenerative disorders such as Alzheimer’s-like pathologies that include amyloid beta aggregation. Despite its i

An ecological metaphor can enable transitions towards regenerative circular economies. Yet, this potential remains latent because its conceptual development, which is a prerequisite for its practical operationalization, is in its incipient phase and largely vague. To strengthen its epistemological underpinning, we propose a forward-looking interdisciplinary research agenda which brings together th

Aberrant activation of anaplastic lymphoma kinase (ALK) drives neuroblastoma (NB). Previous work identified the RET receptor tyrosine kinase (RTK) as a downstream target of ALK activity in NB models. We show here that ALK activation in response to ALKAL2 ligand results in the rapid phosphorylation of RET in NB cells, providing additional insight into the contribution of RET to the ALK-driven gene

Tumors with anaplastic lymphoma kinase (ALK) fusion rearrangements, including non-small-cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. Although mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been dis

The silicon isotope composition (δ30Si) of biogenic silica is often used as an archive of past environmental conditions. For example, sponge spicule δ30Si is known to be related to seawater-dissolved Si concentrations. Such a proxy application requires that the δ30Si is not diagenetically altered—or at least that any alteration can be identified and accounted for. Yet the preservation of pristine

Objective To assess patient's self-reported global assessment of health (PGA) in relation to inflammation, pain and disability in patients with rheumatoid arthritis (RA). Methods Data were obtained from the Better Anti-Rheumatic PharmacOTherapy early RA cohort, in which patients were scheduled for follow-up of 15 years. Longitudinal PGA trajectories were identified using hierarchical agglomerative

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

The catalytic conversion of carbon dioxide (CO2) to methanol over Cu/ZnO catalysts is expected to become valuable for recycling CO2. The nature of the Cu-Zn interplay remains a subject of intense debate due to many different Zn species encountered in Cu/ZnO catalysts. In this study, we designed a Cu-Zn catalyst by ion-exchanging Cu into CIT-6, a crystalline microporous zincosilicate with the BEA*

High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale

AIMS: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.METHODS AND RESULTS: The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited

BACKGROUND: This systematic review aims to determine the loads of anti-A and anti-B in plasma-containing blood products that can safely be transfused to adults.MATERIALS AND METHODS: A comprehensive literature search was performed in PubMed, including studies dating back to 1940 until January 1 st, 2023. In total 1,869 articles were screened, describing 86 cases of hemolytic transfusion reactions

Background and Aims: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. Methods: This nationwide register-based study included individuals ≥ 18 years with incident (2008–2019) or prevalent (2008–2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations as weak (e.g., tr

Background: Adrenaline (ADR) is a cornerstone of advanced life support (ALS) in cardiac arrest (CA), although its neurologically favourable survival outcomes remain unclear. ADR increases coronary perfusion pressure (CPP), with levels >15 mmHg associated with successful defibrillation. This study aimed to elucidate the relationship between ADR, myocardial microvascular blood flow, and resuscitatio

Aim of the review: To provide an overview of studies that have published dataregarding region and population size, procedure location, team composition, inclusionand exclusion criteria, outcome parameters, and cost–benefit analyses onextracorporeal membrane oxygenation use for refractory out-of-hospital cardiac arrest.Data sources: A structured systematic literature search of articles published pr

Aim of the review: This review aimed to evaluate the impact of Point-of-care Ultrasound during cardio- pulmonary resuscitation for adult non-traumatic CA on clinical outcomes and survival.Data sources: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed and Embase databases were searched on 14 November 2022. The

After a decade of data falsification scandals and replication failures in psychology and related empirical disciplines, there are urgent calls for open science and structural reform in the publishing industry. In the meantime, however, researchers need to learn how to recognize tell-tale signs of methodological and conceptual shortcomings that make a published claim suspect. I review four key prob