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BACKGROUND: European guidelines recommend the use of a 0h/1h hs-cTn (high-sensitivity cardiac troponin) protocol in patients with acute chest pain. We aimed to determine the performance of this protocol in routine care when supplemented with patient history and ECG and a recommendation to refrain from noninvasive testing in low-risk patients.METHODS AND RESULTS: This was a pre- and postimplementat
The prospect of death influences people’s thoughts about and how they deal with their remaining time. We aimed to understand whether patients with progressive, life-limiting diseases are oriented in the past, present, or future and how they deal with temporality. We conducted 57 in-depth interviews with end-of-life patients in 10 countries using thematic analysis at three levels (i.e., locally in
Ett oxymoron är ett uttryck bildat av motsatser, som talande tystnad, bitterljuv eller lysa med sin frånvaro. Morris Wikström ser hur ett kritiskt poetiskt grepp tagits över av totalitär politik.
We study the characteristic polynomial pn(x)=∏j=1n(|zj|-x) where the zj are drawn from the Mittag–Leffler ensemble, i.e. a two-dimensional determinantal point process which generalizes the Ginibre point process. We obtain precise large n asymptotics for the moment generating function E[euπIm\,lnpn(r)eaRe\,lnpn(r)], in the case where r is in the bulk, u ϵ R and a ϵ N. This expectation involves an n
This paper discusses how language training for refugees is implemented by the local authorities in Finland and Sweden. The responsibility, production and financing of this specific integration service, language training, is distributed over a multitude of actors in a multidimensional governance structure. We apply a conceptual framework based on intergovernmental relations and conflictual policy p
Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal studies, yet these models do not efficiently recapitulate the complexity of the human brain, and further refinement is necessary before clinical tran
The effective material response as observed at a macro level is a manifestation of the material microstructure and lower scale processes. Due to their distinct atomic arrangement, compared to bulk material, grain boundaries significantly affect the electrical properties of metals. However, a scale-bridging understanding of the associated microstructure–property relation remains elusive so that phe
Aim Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive). Methods The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questio
Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain
This chapter aims to examine the impact of the international anticorruption agenda on the business and investment climate and legal culture in Uzbekistan. In undertaking this task, I specifically emphasise the daily life of anticorruption laws, policies, and agencies in Uzbekistan in order to understand how domestic institutions and actors perceive, interpret, negotiate, and challenge global antic
INTRODUCTION: We aimed to assess the impact of cholinesterase inhibitors (ChEIs) and memantine on cognition, major adverse cardiovascular events (MACE) and mortality in dementia with Lewy bodies (DLB). METHODS: A total of 1,095 incident DLB patients from the Swedish Registry on cognitive/dementia disorders were included. Using an inverse probability of treatment weighting, the effect of initiating
STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from childhood cancer patients positively correlates with SRY-Box transcription factor 9 (SOX9) expression in Sertoli cells, which in turn negatively corr
Introduction: Infective endocarditis (IE) is a challenging diagnosis to suspect and to confirm. The purpose of this study was to clarify how often IE is suspected already on hospital admission, which clinical signs trigger the physicians’ suspicions and to investigate if the empirical treatment is adequate. Methods: A retrospective observational study of cases with definitive IE, during 2018–2019
