The TCF4 gene encodes for the basic helix–loop–helix transcription factor 4 (TCF4), which plays an important role in the development of the central nervous system (CNS). Haploinsufficiency of TCF4 was found to cause Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder. Recently, the screening of a large cohort of medulloblastoma (MB), a highly aggressive embryonal brain tumor, reveal

This article analyses discourses about self-supporting women in Swedish women’s magazines in the 1920s, after the attainment of legal equality in marriage and the acquisition of the right to vote. The self-supporting middle class woman was a controversial figure in this context. On the one hand symbolizing freedom and independence, she was on the other hand ridiculed and labelled mannish and unatt

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide

In the context of complex intergenerational challenges such as climate change and sustainable development, it is increasingly important for scientists and policy-makers to actively engage with and support the meaningful participation of youth in policy and decision-making. This research evaluates the effectiveness and impact of the Youth in Landscapes Initiative in supporting the active participat

Aims: Assessment following heart transplantation (HTx) is routinely performed using transthoracic echocardiography. Differences in long-term mortality following HTx related to donor-recipient matching have been reported, but effects of gender on cardiac size and function are not well studied. The aims of this study were to evaluate differences in echocardiographic characteristics of HTx recipients

Geoportals have been widely implemented by national spatial data infrastructures (NSDI) to provide users with the ability to search for geospatial resources over the Internet. This paper proposes an approach that can improve the functionalities of the conventional geoportals by adding recommendation capabilities to the execution mechanisms of geoportals. The geoportals with recommendation capabili

Air pollution is one of the major environmental problems in the industrial and populated cities. Predictive mapping of urban air pollution and sharing the generated maps with the public and city officials have positive impacts on society and environment. This article presents a solution based on distributed processing concepts to generate predictive map of air pollution for the next 24 hours. Apac

Extreme climate events and nonsustainable land use are important drivers altering the functioning of European ecosystems, resulting in loss of the services provided. Yet a consensus method for regular continental scale assessment of ecosystem condition in relation to land degradation (LD) is still lacking. Here, we propose a new remote sensing-based approach allowing for improved, repeated assessm

A new formulation of explicit multistep methods allows variable step-sizes by construction. This formulation can be used to construct time-adaptive strong stability preserving (SSP) multistep methods of any order for the solution of time-dependent PDEs. The new formulation is implemented in a MATLAB package, and some numerical examples are presented.

ETH Zurich Symposium on Doctoral supervision (Keynote talk, abstract))https://www.ethz.ch/en/doctorate/symposium-doctoral-supervision.htmlIn this session, we will describe how Lund University’s courses for doctoral supervisors have evolved over time and how they have been key for learning and development on the individual, collective and organisational level. The courses provide a unique arena that allows supervisors to share and investigate experiences, practices and circumstances that normally are hidden, sometimes deep within dep

The final assessment of Early Stage Researcher (ESR) activities and development follows the trajectory as previously outlined by the MEDEA Mid-term report presented at the Aarhus meetingJanuary 2017. The herein present follow-up consists of three recent activities: •An ESR group statement of pros/cons/ requested activities (Lund meeting Sep 25th 2018).•Individual ESR web survey ratings of each joi

A wide range of research school activities of the MEDEA ESR training programme were monitored through observations and repeated structured individual interviews with participating Early Stage Researchers (ESRs; i.e. doctoral students). In the early stage of the project, instructional video presentations of participating laboratories and key scientific principles turned out helpful for the early st

Swedish dissertations are public, followed by closedassessment committee meetings that only report pass-failvotes. 166 external examiners from 72 doctoral dissertationswere therefore anonymously surveyed for their views on passfail norms, scientific standard of theses and candidates and theacademic independence of the assessed candidate. They werealso asked to relate their assessment to the nation