Brundin P, Karlsson J, Emgård M, Kaminski Schierle GS, Hansson O, Petersén Å and Castilho RF.Cell Transplantation 9: 179-195 (2000)AbstractNeural transplantation is developing into a therapeutic alternative in Parkinson's disease. A major limiting factor is that only 3-20% of grafted dopamine neurons survive the procedure. Recent advances regarding how and when the neurons die indicate that events

https://www.huntington-research.lu.se/improving-survival-grafted-dopaminergic-neurons-review-over-current-approaches - 2025-03-05

Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF and Brundin P.Proceedings of the National Academy of Sciences USA 96: 8727-8732 (1999)AbstractHuntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant HD gene mediates a slowly progressing striatal neuro

https://www.huntington-research.lu.se/transgenic-mice-expressing-huntingtons-disease-mutation-are-resistant-quinolinic-acid-induced - 2025-03-05

Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. We found significantly larger volumes of surviving graft tissue and of striatal-like tissue (P-zone) within the graft, when the host striatum had been subjected to an excit

https://www.huntington-research.lu.se/impact-preceding-excitotoxic-lesion-and-treatment-ciliary-neurotrophic-factor-striatal-graft - 2025-03-05

Petersén Å and Brundin P.Experimental Neurology 160: 402-412 (1999)AbstractCiliary neurotrophic factor (CNTF) has a protective effect on the striatum in animal models of Huntington's disease. However, the mechanism through which it exerts its effect is not clear. In this study, we show that there is a concentration-dependent direct protective effect of CNTF against N-methyl-D-aspartate-mediated ex

https://www.huntington-research.lu.se/effect-cntf-and-calcium-ionophore-a23187-induced-death-cultured-embryonic-stratal-neurons - 2025-03-05

Petersén Å, Mani K and Brundin P.Experimental Neurology 157: 1-18 (1999)AbstractWe review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG repeat in a gene coding for a protein, with unknown function, called huntingtin. There is selective death of striatal and cortical neurons. Both in patients and a trans

https://www.huntington-research.lu.se/recent-advances-pathogenesis-huntingtons-disease - 2025-03-05

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2025-03-05

Brundin P, Petersén Å and Hansson O.Journal of Neurosurgery 90: 804-806 (1999)No abstract available; this is a letter to the editor.The letter 

https://www.huntington-research.lu.se/graft-survival - 2025-03-05

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2025-03-05

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2025-03-05

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2025-03-05

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2025-03-05

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg Foundation Through the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SE

https://www.huntington-research.lu.se/funding - 2025-03-05

Work full time with your business idea Financial support for students in Skåne & Blekinge. The application for Leapfrogs 2025 is now open! Leapfrogs 2025 Info & Application Tips Want to apply to the Leapfrogs 2025 program? Join our digital info session on February 7th, 2025, from 12:00–13:00. We’ll cover essential details, answer your questions, offer insider tips and supply you with the documents

https://www.leapfrogs.lu.se/en/leapfrogs-home - 2025-03-05

Leapfrogs: Elevate Your Business Project to the Next LevelFunding OpportunityLeapfrogs offers a unique opportunity for financial support, specifically designed to help you advance your business project. If you have moved beyond the initial idea stage and are ready to verify and scale your concept, Leapfrogs is here to assist!What We OfferA grant of 40,000 SEK for dedicated work on your business pr

https://www.leapfrogs.lu.se/en/about-leapfrogs - 2025-03-05

How to ApplyEligibility RequirementsTo apply for Leapfrogs 2025, you must:Your project should have:A developed business hypothesis.Completed market research.Engaged in initial customer interactions.Be engaged with the innovation department at your university:This means you have had an initial meeting with a coach at your university.Application ProcessEngage with your innovation departmentFor Lund

https://www.leapfrogs.lu.se/en/application - 2025-03-05

Frequently Asked Questions (FAQ)Q: How do I apply for Leapfrogs?A: To apply for Leapfrogs, you need to be actively engaged with LU Innovation and be in the right phase of your project. The application process is managed through your designated coach at LU Innovation. If you are not yet in contact with us, please book a meeting to get started.Q: What if I'm a student at HKR or BTH?A: Students at Kr

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E-mailcoaching [at] innovation [dot] lu [dot] seVisit usLunds universitetSektionen Forskning, Samverkan och InnovationLU InnovationMedicon VillageScheeletorget 1, LundProject leaderNicolas Arriagada, Innovation developer, LU InnovationE-mail: Nicolas [dot] arriagada [at] innovation [dot] lu [dot] se Contact us Questions? We are happy to help you!coaching [at] innovation [dot] lu [dot] se (coaching

https://www.leapfrogs.lu.se/en/contact - 2025-03-05

Discover what our 2024 Leapfrogs participants valued most from the program.  "The Leapfrogs program this year opened incredible doors to essential entrepreneurial networks, particularly through the connections made at MINC. The atmosphere fostered collaboration, which will be key for my future growth." - Anonymous"Financially, Leapfrogs was a game-changer. It allowed me to dedicate my summer fully

https://www.leapfrogs.lu.se/en/leapfrogs-2024 - 2025-03-05

Empowering tomorrow’s entrepreneurs The Leapfrogs Mentorship Program has been created as an extension of our established coaching support to provide student entrepreneurs with tailored, one-on-one guidance from experienced professionals. This initiative is designed to complement existing financial support, coaching, and training - offering personalized mentorship of experienced entrepreneurs.For s

https://www.leapfrogs.lu.se/en/mentorship-program - 2025-03-05

Discover what our 2024 Leapfrogs participants valued most from the program.  "The Leapfrogs program this year opened incredible doors to essential entrepreneurial networks, particularly through the connections made at MINC. The atmosphere fostered collaboration, which will be key for my future growth." - Anonymous"Financially, Leapfrogs was a game-changer. It allowed me to dedicate my summer fully

https://www.leapfrogs.lu.se/en/mentorship-program-1 - 2025-03-05