Traumatic brain injury (TBI) is a major cause of morbidity and mortality, not least in the elderly. The incidence of aged TBI patients has increased dramatically during the last decades. High age is a highly negative prognostic factor in TBI, and pharmacological treatment options are lacking. We used the controlled cortical impact (CCI) TBI model in 23-month-old male and female mice and analyzed t

We report the first large-scale retrospective cohort study on adolescent and young adult (AYA) polycythemia vera (PV) and essential thrombocythemia (ET) in Japan, a subgroup analysis using Japanese multicenter registry data (JSH-MPN-R18). This study included patients with PV (n = 31) or ET (n = 141) aged 20 to 39 years at the initial visit. Hemorrhage-free survival (HFS) was better in AYA ET than

Critical scholarship has long pointed to the problematic ways in which mainstream International Relations (IR) takes Westphalian state politics to be universally applicable, yet existing analyses fall short of providing an alternative grounding for IR. Departing from the close relationship between medicine and politics, this article advances two arguments. First, Westphalian IR is based on a parti

Försäkringskassan's status report from 2023 shows that more and more people in Sweden are taking sick leave as a result of stress-related mental illness. The reasons behind sick leave are often that for a longer period, you have not experienced a balance between the demands placed on you and the resources and opportunities you have had to meet these demands and this ultimately leads to exhaust

This study aimed to examine how healthcare workers, who have taken part in internal reflection meetings, and counselors, who lead the meetings, describe their experience, their understanding of the purpose of these meetings, and what this means for the healthcare workers' motivation to participate in the internal reflection meetings. The method used was a case study with semi-structured interv

Urban mobility transitions are essential to mitigate climate change and improve the quality of life in cities. Cargo bikes (CBs) show promise in replacing motorised vehicles due to their lower carbon intensity, space efficiency, and ability to reduce air and noise pollution. CB sharing relieves users from purchase and maintenance costs. However, it is mainly adopted by individuals with high enviro

Sagarmatha (Everest) has long been recognised as one of the principal goals of global adventure tourism. Supported by high-altitude workers, paying climbers on Sagarmatha have the opportunity to tread in the footsteps of colonial pioneers such as George Mallory and Sir Edmund Hillary. Ever since the first attempt was made to summit Sagarmatha there has been an appreciation amongst the climbing com

Reuse and recycling were important, but often forgotten, parts of managing the preindustrial fashionable wardrobe. Through researching diaries and extant garments from Swedish collections, the sources reveal everyday textile practices of costly textiles, mending, turning, altering, using old fabric or garments for new, change of parts or color, and reuse of textile material for new fabrics. The soReuse and recycling were important, but often forgotten, parts of managing the preindustrial fashionable wardrobe. Through researching diaries and extant garments from Swedish collections, the sources reveal everyday textile practices of costly textiles, mending, turning, altering, using old fabric or garments for new, change of parts or color, and reuse of textile material for new fabrics. The so

This study examined driver failure and traffic conflict using a driving simulator during lane-change scenarios on a 2+1 road, focusing on differences between day and night conditions. Data on driver failure status and driving behavior were captured through a survey. The study also evaluated driver performance and electrodermal activity. The findings revealed that nighttime lane changes had a short

Polydiacetylene (PDA) holds promise as a versatile material for biosensing applications due to its unique optical properties and self-assembly capabilities. In this study, we developed a colorimetric detection biosensor system utilizing PDA and aptamer for the detection of microcystin-LR (MC-LR), a potent hepatotoxin found in cyanobacteria-contaminated environments. The biosensor was constructed b

Introduction: This study aimed to understand the influence of diet and nutrition items on gastrointestinal symptoms in patients with Hirschsprung Disease (HD). Method: An online questionnaire was created to obtain patient-reported outcomes using the multinational Holistic Care in Hirschsprung Disease Network. This was distributed in Dutch, English, German, Italian, Polish, and Swedish via patient

High-latitude vegetation experience different temperatures than the ambient air temperature. While lacking a regional plant temperature product, we drove the dynamic ecosystem model, LPJ-GUESS, with widely used ERA5-land surface temperature (Tsurf, at radiative equilibrium) and air temperature to understand ecosystem process responses to these two temperatures. We show that tundra plants' growth i

Soil pore space, considered the most complex biomaterial that exists, generates a complex environment, that gives rise to a wide variety of properties, such as microbial diversity and carbon storage. Soils contain, at the same time, the largest carbon reservoir on earth and an immense amount of nutrient-limited microbial biomass. The reason why this carbon is not consumed by soil microbes is attri

Mutations in the PINK1 and PRKN genes are the most frequent genetic cause of early-onset Parkinson disease. The pathogenic p.R275W substitution in PRKN is the most frequent substitution observed in patients, and thus far has been characterized mostly through overexpression models that suggest a possible gain of toxic misfunction. However, its effects under endogenous conditions are largely unknown

Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz

Background: The Occupational Balance Questionnaire (OBQ11) is a commonly used instrument for measuring self-rated occupational balance. It needs further development, and therefore an additional 11 tentative items have been developed. One aspect of this is studying the interpretations and reasoning of people responding to the items/instrument. Aim: The aim of this study was to explore and describe

Background Task-sharing of spinal anaesthesia care by non-specialist graduate physicians, termed medical officers (MOs), is commonly practised in rural Indian healthcare facilities to mitigate workforce constraints. We sought to assess whether spinal anaesthesia failure rates of MOs were non-inferior to those of consultant anaesthesiologists (CA) following a standardised educational curriculum. Me

Since the agreement of the Millennium Development Goals, many of the international community’s foremost stabilisation efforts have unravelled, with cascading instability afflicting neighboring states. Multiple governments and political entities have begun to turn away from long-term Western security partnerships, and realign with actors such as Russia. This realignment has been pursued even though