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Background: Chronic kidney disease (CKD) affects 6–10% of adults and often remains undiagnosed until advanced stages, leading to inadequate management. This study compared diagnosed, proxy-diagnosed, and undiagnosed CKD patients regarding prevalence, clinical assessment, nephroprotective treatment, healthcare utilization, and mortality. Methods: This retrospective observational study analyzed Regi

Self-harm, including nonsuicidal self-injury and suicide attempts, is common among youth, associated with elevated psychopathology, suicide risk, and increased demand for clinical services. Despite advances in understanding and treatment, few interventions have demonstrated efficacy in randomized controlled trials (RCTs), which are considered the gold standard for evaluating treatment effects by r

Characteristic Mode analysis is a widely used technique in antenna design, providing insight into the fundamental electromagnetic behavior of radiating structures. In this paper, we establish fundamental bounds on the slope of characteristic mode eigenvalues and angles, demonstrating that their rate of change is subject to fundamental constraints for all possible realizations within a given design

The chapter summarizes the different methods available for damage repair after water and/or fire events. Different drying methods as well as their advantages and disadvantages are discussed. This is done separately for timber framing and mass timber constructions. The section for repair after fire events points out the different steps that should be taken after a fire event. This includes methods

In Nordic countries, demand response (DR) programs are critical for enhancing energy flexibility and reducing peak electricity consumption in buildings and industry. Accurate short-term demand forecasting is essential to support these programs, especially in the context of cities with varying levels of data availability. This paper compares three different forecasting approaches for hourly electri

During the last two decades, an active line of research in proof complexity has been into the space complexity of proofs and how space is related to other measures. By now these aspects of the resolution proof system are fairly well understood, but many open problems remain for the related but stronger proof system polynomial calculus (PC/PCR). For instance, the space complexity of many standard “

This article explores the regional embeddedness of bioeconomy innovations in Germany, focusing on “flagship” innovation projects that exemplify the challenges and opportunities of systemic changes towards bioeconomies. While bioeconomies have been promoted as solutions to global challenges and opportunities for sustainable regional development, there are ongoing debates about the actual benefits o

Mystical-type experiences can be induced through techniques like hypnosis and meditation. These experiences are common in near-death experiences (NDEs) and have been linked to paranormal beliefs. This study explored auto-induced cognitive trance (AICT) as a method to induce mystical-type experiences and NDE outside of life threatening situations (NDE-like), as well as examining the influence of fa

Purpose: This study aimed to evaluate the ability of a thigh-worn accelerometer to detect walking during daily life in individuals with Lumbar Spinal Stenosis (LSS). Two hypotheses were made regarding how walking measurements from the accelerometer, a walking test, and an ankle-worn StepWatch would relate in order for the accelerometer to be valid. The hypotheses were: (a) there is no difference b

Venetoclax-obinutuzumab (Ven-Obi) is a standard first-line therapy for chronic lymphocytic leukemia (CLL). The impact of age, fitness, and dose reductions remains unclear. We analyzed patients treated with Ven-Obi in the CLL13 and CLL14 trials, excluding patients with TP53 aberrations. Fitness was assessed using the cumulative illness rating scale (CIRS, >6) and creatinine clearance (≤70 mL

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a progressive loss of motor neurons. Neuroinflammation is apparent in affected tissues, including increased T cell infiltration and activation of microglia, particularly in the spinal cord1,2. Autoimmune responses are thought to have a key role in ALS pathology, and it is hypothesized that T cells contribute to the

Adolescent girls are particularly susceptible to iron deficiency due to increased iron requirements during the pubertal growth spurt, combined with iron loss following menarche. This study aimed to investigate the prevalence of heavy menstrual bleeding in an adolescent population using the SAMANTA questionnaire and to explore its relationship with dietary habits and iron deficiency. This cross-sec

Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antiviral defense, pDCs are assumed to play an essential role in this process; however, robust evidence supporting this dogma is scarce. Genetic or pharmacological manipulations that eliminate pDCs or disrupt their interferon production often affect other cells, confounding interpretat

Solid-state electrolytes, such as lithium lanthanum zirconium oxide (LLZO), show promise as technologies for next-generation high-energy-density batteries, but commercial development has been hindered by a lack of scalable processing methods. Current fabrication methods are costly or require long annealing steps to create dense films. We report an atmospheric pressure blown-arc nitrogen plasma jet

Solar-driven hydrogen production stores renewable energy chemically but suffers from efficiency limitations due to the slow hole transport-dominated recombination, which caused by high valence band degeneracy and hole effective mass. Targeted hole trap regulation is essential to minimize these losses and enhance photocatalytic H2 evolution performance for practical applications. This study address

We explore the challenges facing the current academic training of economists in small European countries such as Sweden. The monolithic focus on publishing in the top-five journals, which prioritizes methodological rigor over problem-driven research, is often a threat to social relevance and policy applicability. This limits pluralism, excludes many talented economists, and fails to prepare gradua

Glioblastoma (GBM) is characterized by fast progression, infiltrative growth pattern, and a high relapse rate. A defining feature of GBM is the existence of spatially and functionally distinct cellular niches, where malignant cells engage in paracrine crosstalk with cell types comprising the tumor microenvironment. Here, we identify pericytes as the most active paracrine signaling hub within the t

This paper presents a novel approach to economic dispatch (ED) optimization in power systems through the application of Proximal Policy Optimization (PPO), an advanced reinforcement learning algorithm. The economic dispatch problem, a fundamental challenge in power system operations, involves optimizing the generation output of multiple units to minimize operational costs while satisfying load dem