Background--The relationship between "on-treatment" low platelet reactivity and longitudinal risks of major bleeding dual antiplatelet therapy following acute coronary syndromes remains uncertain, especially for patients who do not undergo percutaneous coronary intervention. Methods and Results--We analyzed 2428medicallymanaged acute coronary syndromes patients fromthe Targeted Platelet Inhibition

This book seeks to explore historical changes in the lifeworld of the Mi'kmaq Indians of Eastern Canada. The Mi'kmaq culture hero Kluskap serves as a key persona in discussing issues such as traditions, changing conceptions of land, and human-environmental relations. In order not to depict Mi'kmaq culture as timeless, two important periods in its history are examined. Within the first period, betw

Gebel el-Silsila (Mountain of Chain) is located between Kom Ombo and Edfu on both banks of the Nile where it reaches its narrowest point. The site is generally known for its many Pharaonic cenotaphs, stelae and the speos of Horemheb, but it was once also the world’s largest quarry. As such it was renowned for its high quality sandstone, and the stone was extracted and transported to all overUpper Gebel el Silsila (Mountain of Chain) is located between Kom Ombo and Edfu on both banks of the Nile where it reaches its narrowest point. The site is generally known for its many Pharaonic cenotaphs, stelai and the speos of Horemheb, but it was once also the world’s largest quarry. As such it was renowned for its high quality sandstone, and the stone was extracted and transported to all over Upper

The current paper is aimed as a primary publication of eight scarabs assembled by the Swedish-Egyptian excavation team between 2015 and 2016, found in private tombs of the Eighteenth Dynasty necropolis at Gebel el-Silsila East. Each entry includes information about field number, dimensions, material, description, inscription, and dating if possible. Typology conclusions are based on comparisons to

Farmers are exposed to substantial weather and market related risks. Rational farmers seek to avoid large losses. Future climate change and energy price fluctuations therefore make adaptating to increased risks particularly important for them. Managing soil natural capital—the capacity of the soil to generate ecosystem services of benefit to farmers—has been proven to generate the double dividend:

When changes happen to big data analytics (BDA) applications in the Cloud at runtime, the affected BDA applications have to be re-deployed to accommodate the changes. Deciding the most suitable deployment is critical and complicated. Although there have been various research studies working on BDA application management, autonomic deployment decision making is still an open research issue. This pa

The results of a search for vector-like top quarks using events with exactly one lepton, at least four jets, and large missing transverse momentum are reported. The search is optimised for pair production of vector-like top quarks in the Z() t + X decay channel. LHC pp collision data at a centre-of-mass energy of s=13 TeV recorded by the ATLAS detector in 2015 and 2016 are used, corresponding to a

We explore a promising new approach to understanding the neural filter mechanisms intermediate in motion processing at low luminance. We carefully account for the known filter properties of early stages of visual processing in a nocturnal moth, and then measured spatiotemporal tuning of higher order neurons. We then use a computational model to identify likely strategies used to reject noisy signa

People struggle to name odors [1–4]. This has been attributed to a diminution of olfaction in trade-off to vision [5–10]. This presumption has been challenged recently by data from the hunter-gatherer Jahai who, unlike English speakers, find odors as easy to name as colors [4]. Is the superior olfactory performance among the Jahai because of their ecology (tropical rainforest), their language fami

IMPORTANCE: Visual assessment of amyloid positron emission tomographic (PET) images has been approved by regulatory authorities for clinical use. Several immunoassays have been developed to measure β-amyloid (Aβ) 42 in cerebrospinal fluid (CSF). The agreement between CSF Aβ42 measures from different immunoassays and visual PET readings may influence the use of CSF biomarkers and/or amyloid PET ass

The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest

The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (JawNO), airway diffusing capacity (DawNO) and airway wall content (CawNO) wi

Diagnosing mitochondrial disease (MD) is a challenge. In addition to genetic analyses, clinical practice is to perform invasive procedures such as muscle biopsy for biochemical and histochemical analyses. Blood cell respirometry is rapid and noninvasive. Our aim was to explore its possible role in diagnosing MD.MethodsBlood samples were collected from 113 pediatric patients, for whom MD was a diff

This article investigates whether regime-based asset allocation can effectively respond to changes in financial regimes at the portfolio level in an effort to provide better long-term results when compared to a static 60/40 benchmark. The potential benefit from taking large positions in a few assets at a time comes at the cost of reduced diversification. The authors analyze this trade-off in a mul

No Child Left Behind och Race to the Top är namnen på två stora skolreformer i USA. Common Core är namnet på den nationellt övergripande standardiseringen av de tester som kopplats till reformarbetet. Hur har reformerna utfallit? Martin Malmström kommenterar den amerikanska utvecklingen. (red)