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Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mo

Unmanned aerial systems (UAS) carrying commercially sold multispectral sensors equipped with a sunshine sensor, such as Parrot Sequoia, enable mapping of vegetation at high spatial resolution with a large degree of flexibility in planning data collection. It is, however, a challenge to perform radiometric correction of the images to create reflectance maps (orthomosaics with surface reflectance) a

Sodium carbonate pretreatment, an environmentally-friendly and efficient pretreatment, was used to improve solid-state ethanol production from corn stover (CS). To further enhance ethanol yield from the pretreated CS, especially at low enzyme loadings, a combined pretreatment, including steam and sodium carbonate pretreatments, was developed. The removal/modification of lignin by sodium carbonate

We establish an exactly tight relation between reversiblepebblings of graphs and Nullstellensatz refutations of pebbling formulas,showing that a graph G can be reversibly pebbled in time t and space s if and only if there is a Nullstellensatz refutation of the pebbling formulaover G in size t + 1 and degree s (independently of the field in whichthe Nullstellensatz refutation is made). We use this

Diffusion tensor imaging provides increased sensitivity to microstructural tissue changes compared to conventional anatomical imaging but also presents limited specificity. To tackle this problem, the DIAMOND model subdivides the voxel content into diffusion compartments and draws from diffusion-weighted data to estimate compartmental non-central matrix-variate Gamma distributions of diffusion ten

Determining non-metallic inclusions (NMIs) are essential to engineer ultra-high-strength steel as they play decisive role on performance and critical to probe via conventional techniques. Herein, advanced Synchrotron X-ray absorption coupled with photoemission electron microscopy and first-principles calculations are employed to provide the structure, local bonding structure and electronic propert

American bison (Bison bison L.) have recovered from the brink of extinction over the past century. Bison reintroduction creates multiple environmental benefits, but impacts on greenhouse gas emissions are poorly understood. Bison are thought to have produced some 2 Tg yr-1 of the estimated 9 15 Tg yr-1 of pre-industrial enteric methane emissions, but few measurements have been made due to their mo

Why do some foreign ministers stay longer in office than others? Are they punished when the country loses a war? Several scholars have focused on the tenure of leaders as an important predictor of foreign policy outcomes, such as war onset, creating an interest in leadership survival. We here shift the focus to the survival of other important politicians in cabinet-foreign ministers, hypothesizing

Firm-sponsored online user communities have become product innovation and support hubs of strategic importance to firms. Product users and host firm employees comprise the participants of firm-sponsored online user communities. The online user community provides a forum wherein the product users and firm employees discuss questions, problems or issues resulting from the use of host firms’ products

When researchers analyze data, it typically requires significant effort in data preparation to make the data analysis ready. This often involves cleaning, pre-processing, harmonizing, or integrating data from one or multiple sources and placing them into a computational environment in a form suitable for analysis. Research infrastructures and their data repositories host data and make them availab

The metal-poor stars in the bulge are important relics of the Milky Way's formation history, as simulations predict that they are some of the oldest stars in the Galaxy. In order to determine if they are truly ancient stars, we must understand their origins. Currently, it is unclear if the metal-poor stars in the bulge ([Fe/H] < -1 dex) are merely halo interlopers, a unique accreted population, pa

A disease risk index (DRI) that was developed for adults with hematologic malignancy who were undergoing hematopoietic cell transplantation is also being used to stratify children and adolescents by disease risk. Therefore, to develop and validate a DRI that can be used to stratify those with AML and ALL by their disease risk, we analyzed 2569 patients aged <18 years with acute myeloid (AML; n = 1

Researchers have known for decades that silicon plays a major role in biogeochemical and plant-soil processes in terrestrial systems. Meanwhile, plant biologists continue to uncover a growing list of benefits derived from silicon to combat abiotic and biotic stresses, such as defense against herbivory. Yet despite growing recognition of herbivores as important ecosystem engineers, many major gaps

Developing organisms typically mature earlier and at larger sizes in favorable growth conditions, while in rarer cases, maturity is delayed. The rarer reaction norm is easily accommodated by general life history models, whereas the common pattern is not. Theory suggests that a solution to this paradox lies in the existence of critical size thresholds at which maturation or metamorphosis can commen

Why do citizens’ decisions made because they favour the mitigation of climate change outnumber those made because they favour adaptation to its impacts? Using data collected in a survey of 338 citizens of Malmö, Sweden, we tested two hypotheses. H1: the motivation for personal decisions because they favour adaptation to the impacts of climate change correlates with the decision-making agent´s know

Objectives Socioeconomic disparities in smoking prevalence remain a challenge to public health. The objective of this study was to present a simple methodology that displays intersectional patterns of smoking and quantify heterogeneities within groups to avoid inappropriate and potentially stigmatising conclusions exclusively based on group averages. Setting This is a cross-sectional observational

Introduction As part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously defined clinical and patient-reported outcomes for prostate cancer (PCa). Methods and analysis This research project will follow the following four st