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The Kathmandu Valley in Nepal is facing a water quantity and quality crisis due to rapid urbanization and haphazard water and wastewater planning and management. Annually, groundwater extractions in the Kathmandu Valley exceed capture, resulting in groundwater table declines. Streams are often important sources of recharge to (or destination of discharges from) aquifers. However, stream-aquifer in

The fossiliferous Eocene carbonate reservoir interval of the offshore Hasdrubal Field has a diagenetic history in which dolomitisation of micrite-rich facies has significantly enhanced reservoir quality. Using published information on the diagenetic evolution, digital textural representations of the limestones and dolostones are created using the Multi-Component Architecture Method (MCAM). This te

A new integral equation formulation is presented for the Maxwell transmission problem in Lipschitz domains. It builds on the Cauchy integral for the Dirac equation, is free from false eigenwavenumbers for a wider range of permittivities than other known formulations, can be used for magnetic materials, is applicable in both two and three dimensions, and does not suffer from any low-frequency break

Multiple guidelines exist for the management of aortic stenosis (AS). We systematically reviewed current guidelines and recommendations, developed by national or international medical organizations, on management of AS to aid clinical decision-making. Publications in MEDLINE and EMBASE between 1 June 2010 and 15 January 2021 were identified. Additionally, the International Guideline Library, Natio

The East Asian summer monsoon (EASM) northern boundary is a critical indicator of EASM variations. Movement of the boundary is modulated by both the EASM and the mid-latitude westerlies. Here, we use the Earth system model EC-Earth to quantify the contribution of orbital forcing and vegetation feedbacks in modulating the movement of EASM northern boundary. The results show that the simulated EASM

Distribution of responsibility is one of the main focus areas in discussions about climate change ethics. Most of these discussions deal with the distribution of responsibility for climate change mitigation at the international level. The aim of this paper is to investigate if and how these principles can be used to inform the search for a fair distribution of responsibility for climate change ada

Background and purpose: Epstein–Barr virus (EBV) and human herpesvirus 6A (HHV-6A) are associated with increased risk of multiple sclerosis (MS). Conversely, infection with cytomegalovirus (CMV) has been suggested to reduce the risk of MS but supporting data from presymptomatic studies are lacking. Here, it was sought to increase the understanding of CMV in MS aetiology. Methods: A nested case–con

This study investigates the drivers of water use efficiency (WUE), a key metric of water resources management, and its changes over eight regions across China from 1982 to 2015 based on gross primary production (GPP) and actual evapotranspiration (AET) datasets. The order of seasonal change of WUE from large to small is autumn, summer, spring and winter. The drivers include seven variables, air te

This paper reports the main results of an experimental study on the mechanics of intensely fissured natural clays, extending our previous studies on scaly clay from Santa Croce di Magliano. While previous work focused on the influence of the orientation of fissures with respect to the loading direction, the present investigation specifically explores an additional, important variable: the stress l

We present a 13Ccarb chemostratigraphy for the Late Ordovician Hirnantian Stage based on 208 whole-rock samples from six outcrops in the Oslo-Asker district, southern Norway. Our data include the Norwegian type section for the Hirnantian Stage and Ordovician-Silurian boundary at Hovedøya Island. The most complete record of the Hirnantian Isotope Carbon Excursion (HICE) is identified in a coastal e

We study learning in a decentralized pairwise adverse selection economy, where buyers have access to the quality of traded goods but not to the quality of non- traded goods. Buyers categorize ask prices in order to predict quality as a function of ask price. The categorization is endogenously determined so that outcomes that are observed more often are categorized more finely, and within each cate

Introduction: The aim of this study was to evaluate if surface guided radiotherapy (SGRT) can decrease patient positioning time for localized prostate cancer patients compared to the conventional 3-point localization setup method. The patient setup accuracy was also compared between the two setup methods. Materials and methods: A total of 40 localized prostate cancer patients were enrolled in this

Despite widespread metal pollution of coastal ecosystems, little is known of its effect on marine phytoplankton. We designed a co-cultivation experiment to test if toxic dose–response relationships can be used to predict the competitive outcome of two species under metal stress. Specifically, we took into account intraspecific strain variation and selection. We used 72 h dose–response relationship